| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom; and
Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge, United Kingdom
Leishmania major infection is useful as an
experimental model to define factors responsible for the development
and maintenance of Th cell immune responses. Studies using inbred mouse
strains have identified that the Th1 response characteristic of C57BL/6
mice results in healing, whereas BALB/c mice fail to control the
infection due to the generation of an inappropriate Th2 response. We
now demonstrate that IL-13 is a key factor in determining
susceptibility to L. major infection. Overexpression of
IL-13 in transgenic mice makes the normally resistant C57BL/6 mouse
strain susceptible to L. major infection even in the
absence of IL-4 expression. This susceptibility correlates with a
suppression of IL-12 and IFN-
expression. Furthermore, using BALB/c
mice deficient in the expression of IL-4, IL-13, or both IL-13 and
IL-4, we demonstrate that IL-13-deficient mice are resistant to
infection and that there is an additive effect of deleting both IL-4
and IL-13.
This article has been cited by other articles:
|
|
 |
|
  A. Maurer-Cecchini, S. Decuypere, F. Chappuis, C. Alexandrenne, S. De Doncker, M. Boelaert, J.-C. Dujardin, L. Loutan, J.-M. Dayer, G. Tulliano, et al. Immunological Determinants of Clinical Outcome in Peruvian Patients with Tegumentary Leishmaniasis Treated with Pentavalent Antimonials Infect. Immun., May 1, 2009; 77(5): 2022 - 2029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. Wheat, K. E. Pauken, R. V. Morris, and R. G. Titus Lutzomyia longipalpis Salivary Peptide Maxadilan Alters Murine Dendritic Cell Expression of CD80/86, CCR7, and Cytokine Secretion and Reprograms Dendritic Cell-Mediated Cytokine Release from Cultures Containing Allogeneic T Cells J. Immunol., June 15, 2008; 180(12): 8286 - 8298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Salhi, V. Rodrigues Jr., F. Santoro, H. Dessein, A. Romano, L. R. Castellano, M. Sertorio, S. Rafati, C. Chevillard, A. Prata, et al. Immunological and Genetic Evidence for a Crucial Role of IL-10 in Cutaneous Lesions in Humans Infected with Leishmania braziliensis J. Immunol., May 1, 2008; 180(9): 6139 - 6148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhao, B. Zheng, Y. Huang, D. Yang, S. Katzman, C. Chang, D. Fowell, and W.-p. Zeng Interaction between GATA-3 and the Transcriptional Coregulator Pias1 Is Important for the Regulation of Th2 Immune Responses J. Immunol., December 15, 2007; 179(12): 8297 - 8304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Muller, W. Stenzel, G. Kohler, C. Werner, T. Polte, G. Hansen, N. Schutze, R. K. Straubinger, M. Blessing, A. N. J. McKenzie, et al. IL-13 Induces Disease-Promoting Type 2 Cytokines, Alternatively Activated Macrophages and Allergic Inflammation during Pulmonary Infection of Mice with Cryptococcus neoformans J. Immunol., October 15, 2007; 179(8): 5367 - 5377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Silvestre, A. Cordeiro-Da-Silva, N. Santarem, B. Vergnes, D. Sereno, and A. Ouaissi SIR2-Deficient Leishmania infantum Induces a Defined IFN-{gamma}/IL-10 Pattern That Correlates with Protection J. Immunol., September 1, 2007; 179(5): 3161 - 3170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nagase, K. M. Jones, C. F. Anderson, and N. Noben-Trauth Despite Increased CD4+Foxp3+ Cells within the Infection Site, BALB/c IL-4 Receptor-Deficient Mice Reveal CD4+Foxp3-Negative T Cells as a Source of IL-10 in Leishmania major Susceptibility J. Immunol., August 15, 2007; 179(4): 2435 - 2444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. M. Roberts Current understandings on the immunology of leishmaniasis and recent developments in prevention and treatment Br. Med. Bull., July 17, 2006; 75-76(1): 115 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Murray, C. W. Tsai, J. Liu, and X. Ma Visceral Leishmania donovani Infection in Interleukin-13-/- Mice Infect. Immun., April 1, 2006; 74(4): 2487 - 2490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Holscher, B. Arendse, A. Schwegmann, E. Myburgh, and F. Brombacher Impairment of Alternative Macrophage Activation Delays Cutaneous Leishmaniasis in Nonhealing BALB/c Mice J. Immunol., January 15, 2006; 176(2): 1115 - 1121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. M. Roberts, C. B. Stober, A. N McKenzie, and J. M. Blackwell Interleukin-4 (IL-4) and IL-10 Collude in Vaccine Failure for Novel Exacerbatory Antigens in Murine Leishmania major Infection Infect. Immun., November 1, 2005; 73(11): 7620 - 7628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Murray, K. C. Flanders, D. D. Donaldson, J. P. Sypek, P. J. Gotwals, J. Liu, and X. Ma Antagonizing Deactivating Cytokines To Enhance Host Defense and Chemotherapy in Experimental Visceral Leishmaniasis Infect. Immun., July 1, 2005; 73(7): 3903 - 3911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Tonui, J. S. Mejia, L. Hochberg, M. L. Mbow, J. R. Ryan, A. S. T. Chan, S. K. Martin, and R. G. Titus Immunization with Leishmania major Exogenous Antigens Protects Susceptible BALB/c Mice against Challenge Infection with L. major Infect. Immun., October 1, 2004; 72(10): 5654 - 5661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Kitching, A. L. Turner, G. R.A. Wilson, K. L. Edgtton, P. G. Tipping, and S. R. Holdsworth Endogenous IL-13 Limits Humoral Responses and Injury in Experimental Glomerulonephritis but Does Not Regulate Th1 Cell-Mediated Crescentic Glomerulonephritis J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2373 - 2382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. C. Babay, H. Louzir, C. Kebaier, S. Boubaker, K. Dellagi, and P.-A. Cazenave Inbred Strains Derived from Feral Mice Reveal New Pathogenic Mechanisms of Experimental Leishmaniasis Due to Leishmania major Infect. Immun., August 1, 2004; 72(8): 4603 - 4611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saeftel, A. Krueger, S. Arriens, V. Heussler, P. Racz, B. Fleischer, F. Brombacher, and A. Hoerauf Mice Deficient in Interleukin-4 (IL-4) or IL-4 Receptor {alpha} Have Higher Resistance to Sporozoite Infection with Plasmodium berghei (ANKA) than Do Naive Wild-Type Mice Infect. Immun., January 1, 2004; 72(1): 322 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Noben-Trauth, R. Lira, H. Nagase, W. E. Paul, and D. L. Sacks The Relative Contribution of IL-4 Receptor Signaling and IL-10 to Susceptibility to Leishmania major J. Immunol., May 15, 2003; 170(10): 5152 - 5158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N.J. McKenzie and P. G. Fallon Decoy Receptors in the Regulation of T Helper Cell Type 2 Responses J. Exp. Med., March 17, 2003; 197(6): 675 - 679. [Full Text] [PDF]
|
|
|
|
|
|
U. M. Padigel and J. P. Farrell CD40-CD40 Ligand Costimulation Is Not Required for Initiation and Maintenance of a Th1-Type Response to Leishmania major Infection Infect. Immun., March 1, 2003; 71(3): 1389 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. B. Sousa-Atta, G. S. Salame, A. D'Oliveira Jr, R. P. Almeida, A. M. Atta, and E. M. Carvalho Immunoglobulin E Antileishmanial Antibody Response in Cutaneous Leishmaniasis Clin. Vaccine Immunol., January 1, 2002; 9(1): 101 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Titus, G. K. DeKrey, R. V. Morris, and M. B. P. Soares Interleukin-6 Deficiency Influences Cytokine Expression in Susceptible BALB Mice Infected with Leishmania major but Does Not Alter the Outcome of Disease Infect. Immun., August 1, 2001; 69(8): 5189 - 5192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B. Kremer, M. P. Gould, K. D. Cooper, and F. P. Heinzel Pretreatment with Recombinant Flt3 Ligand Partially Protects against Progressive Cutaneous Leishmaniasis in Susceptible BALB/c Mice Infect. Immun., February 1, 2001; 69(2): 673 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Mountford, K. G. Hogg, P. S. Coulson, and F. Brombacher Signaling via Interleukin-4 Receptor {alpha} Chain Is Required for Successful Vaccination against Schistosomiasis in BALB/c Mice Infect. Immun., January 1, 2001; 69(1): 228 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Oshima and R. K. Puri Characterization of a Powerful High Affinity Antagonist That Inhibits Biological Activities of Human Interleukin-13 J. Biol. Chem., April 27, 2001; 276(18): 15185 - 15191. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
