The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pittet, M. J.
Right arrow Articles by Romero, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pittet, M. J.
Right arrow Articles by Romero, P.
The Journal of Immunology, 2000, 164: 1148-1152.
Copyright © 2000 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+ T Cells Closely Correlates with CD56 Surface Expression1

Mikaël J. Pittet, Daniel E. Speiser, Danila Valmori, Jean-Charles Cerottini and Pedro Romero2

Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne, Switzerland

Recent data suggest that human effector CD8+ T cells express a distinct CD27-CD45RAhigh (CD57+CD28-CD11ahigh) phenotype. Here, we propose that CTL effector function correlates better with CD56 (neuronal cell adhesion molecule (NCAM)) surface expression. CD56 was absent on cord blood CD8+ T cells, but was expressed by 4–30% of freshly isolated circulating CD8+ T cells from 15 adults. Dramatic oligoclonal expansions in 3/3 individuals were confined to the CD56+ subset of CD8+ T cells. The CD56+ subset generally contained high amounts of intracellular perforin and granzyme B. Finally, direct cytolytic capacity was closely restricted to the CD56+(CD45RAhigh) cells, better than to CD27-CD45RAhigh cells in 5/5 individuals analyzed. Thus, the phenotype corresponding to the circulating effector CD8+ T cell pool may be simplified and more precisely defined by the use of just two surface markers: CD8 and CD56.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad
Antiviral NK cell responses in HIV infection: I. NK cell receptor genes as determinants of HIV resistance and progression to AIDS
J. Leukoc. Biol., July 1, 2008; 84(1): 1 - 26.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad
Antiviral NK cell responses in HIV infection: II. viral strategies for evasion and lessons for immunotherapy and vaccination
J. Leukoc. Biol., July 1, 2008; 84(1): 27 - 49.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. A.Z. Alexander, A. Maniar, J.-S. Cummings, A. M. Hebbeler, D. H. Schulze, B. R. Gastman, C. D. Pauza, S. E. Strome, and A. I. Chapoval
Isopentenyl Pyrophosphate-Activated CD56+ {gamma}{delta} T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma
Clin. Cancer Res., July 1, 2008; 14(13): 4232 - 4240.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Waziri, B. Killory, A. T. Ogden III, P. Canoll, R. C. E. Anderson, S. C. Kent, D. E. Anderson, and J. N. Bruce
Preferential In Situ CD4+CD56+ T Cell Activation and Expansion within Human Glioblastoma
J. Immunol., June 1, 2008; 180(11): 7673 - 7680.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Guia, C. Cognet, L. de Beaucoudrey, M. S. Tessmer, E. Jouanguy, C. Berger, O. Filipe-Santos, J. Feinberg, Y. Camcioglu, J. Levy, et al.
A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo
Blood, May 15, 2008; 111(10): 5008 - 5016.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. Korosec, K. Osolnik, I. Kern, M. Silar, K. Mohorcic, and M. Kosnik
Expansion of Pulmonary CD8+CD56+ Natural Killer T-Cells in Hypersensitivity Pneumonitis
Chest, October 1, 2007; 132(4): 1291 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. Golden-Mason, N. Castelblanco, C. O'Farrelly, and H. R. Rosen
Phenotypic and Functional Changes of Cytotoxic CD56pos Natural T Cells Determine Outcome of Acute Hepatitis C Virus Infection
J. Virol., September 1, 2007; 81(17): 9292 - 9298.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. Cohavy and S. R. Targan
CD56 Marks an Effector T Cell Subset in the Human Intestine
J. Immunol., May 1, 2007; 178(9): 5524 - 5532.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
P. J. Scaife, J. N. Bulmer, S. C. Robson, B. A. Innes, and R. F. Searle
Effector Activity of Decidual CD8+ T Lymphocytes in Early Human Pregnancy
Biol Reprod, October 1, 2006; 75(4): 562 - 567.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. A. Campillo, J. A. Martinez-Escribano, M. R. Moya-Quiles, L. A. Marin, M. Muro, N. Guerra, A. Parrado, M. Campos, J. F. Frias, A. Minguela, et al.
Natural Killer Receptors on CD8 T Cells and Natural Killer Cells from Different HLA-C Phenotypes in Melanoma Patients.
Clin. Cancer Res., August 15, 2006; 12(16): 4822 - 4831.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Atanackovic, K. Pollok, C. Faltz, I. Boeters, R. Jung, A. Nierhaus, K.-M. Braumann, D. K. Hossfeld, and S. Hegewisch-Becker
Patients with solid tumors treated with high-temperature whole body hyperthermia show a redistribution of naive/memory T-cell subtypes
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R585 - R594.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. K. Ahn, H. Chung, D.-s. Lee, Y. S. Yu, and H. G. Yu
CD8brightCD56+ T Cells Are Cytotoxic Effectors in Patients with Active Behcet's Uveitis
J. Immunol., November 1, 2005; 175(9): 6133 - 6142.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. Katchar, K. Soderstrom, J. Wahlstrom, A. Eklund, and J. Grunewald
Characterisation of natural killer cells and CD56+ T-cells in sarcoidosis patients
Eur. Respir. J., July 1, 2005; 26(1): 77 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. Dyugovskaya, P. Lavie, M. Hirsh, and L. Lavie
Activated CD8+ T-lymphocytes in obstructive sleep apnoea
Eur. Respir. J., May 1, 2005; 25(5): 820 - 828.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B.-C. Sheu, S.-H. Chiou, H.-H. Lin, S.-N. Chow, S.-C. Huang, H.-N. Ho, and S.-M. Hsu
Up-regulation of Inhibitory Natural Killer Receptors CD94/NKG2A with Suppressed Intracellular Perforin Expression of Tumor-Infiltrating CD8+ T Lymphocytes in Human Cervical Carcinoma
Cancer Res., April 1, 2005; 65(7): 2921 - 2929.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
W. J. Grossman, J. W. Verbsky, B. L. Tollefsen, C. Kemper, J. P. Atkinson, and T. J. Ley
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells
Blood, November 1, 2004; 104(9): 2840 - 2848.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Mosolits, K. Markovic, J.-E. Frodin, L. Virving, C. G. M. Magnusson, M. Steinitz, J. Fagerberg, and H. Mellstedt
Vaccination with Ep-CAM Protein or Anti-Idiotypic Antibody Induces Th1-Biased Response against MHC Class I- and II-Restricted Ep-CAM Epitopes in Colorectal Carcinoma Patients
Clin. Cancer Res., August 15, 2004; 10(16): 5391 - 5402.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
O. D. Perez, D. Mitchell, G. C. Jager, and G. P. Nolan
LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56+CD8+ natural killer cells
Blood, August 15, 2004; 104(4): 1083 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. G. Kitchen, N. R. Jones, S. LaForge, J. K. Whitmire, B.-A. Vu, Z. Galic, D. G. Brooks, S. J. Brown, C. M. R. Kitchen, and J. A. Zack
CD4 on CD8+ T cells directly enhances effector function and is a target for HIV infection
PNAS, June 8, 2004; 101(23): 8727 - 8732.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Atanackovic, A. Block, A. de Weerth, C. Faltz, D. K. Hossfeld, and S. Hegewisch-Becker
Characterization of Effusion-Infiltrating T Cells: Benign versus Malignant Effusions
Clin. Cancer Res., April 15, 2004; 10(8): 2600 - 2608.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Rothenfusser, V. Hornung, M. Ayyoub, S. Britsch, A. Towarowski, A. Krug, A. Sarris, N. Lubenow, D. Speiser, S. Endres, et al.
CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro
Blood, March 15, 2004; 103(6): 2162 - 2169.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. J. Wajchman, C. W. Pierce, V. A. Varma, M. M. Issa, J. Petros, and K. E. Dombrowski
Ex Vivo Expansion of CD8+CD56+ and CD8+CD56- Natural Killer T Cells Specific for MUC1 Mucin
Cancer Res., February 1, 2004; 64(3): 1171 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
K. U. Saikh, B. Dyas, T. Kissner, and R. G. Ulrich
CD56+-T-Cell Responses to Bacterial Superantigens and Immune Recognition of Attenuated Vaccines
Clin. Vaccine Immunol., November 1, 2003; 10(6): 1065 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Beider, A. Nagler, O. Wald, S. Franitza, M. Dagan-Berger, H. Wald, H. Giladi, S. Brocke, J. Hanna, O. Mandelboim, et al.
Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice
Blood, September 15, 2003; 102(6): 1951 - 1958.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Cookson and D. Reen
IL-15 drives neonatal T cells to acquire CD56 and become activated effector cells
Blood, September 15, 2003; 102(6): 2195 - 2197.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
J. E. Bower, P. A. Ganz, N. Aziz, J. L. Fahey, and S. W. Cole
T-Cell Homeostasis in Breast Cancer Survivors With Persistent Fatigue
J Natl Cancer Inst, August 6, 2003; 95(15): 1165 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Strauss, I. Knape, I. Melzner, and K.-M. Debatin
Constitutive Caspase Activation and Impaired Death-Inducing Signaling Complex Formation in CD95-Resistant, Long-Term Activated, Antigen-Specific T Cells
J. Immunol., August 1, 2003; 171(3): 1172 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Dyugovskaya, P. Lavie, and L. Lavie
Phenotypic and Functional Characterization of Blood {gamma}{delta} T Cells in Sleep Apnea
Am. J. Respir. Crit. Care Med., July 15, 2003; 168(2): 242 - 249.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y.-J. Kim, R. R. Brutkiewicz, and H. E. Broxmeyer
Role of 4-1BB (CD137) in the functional activation of cord blood CD28-CD8+ T cells
Blood, October 16, 2002; 100(9): 3253 - 3260.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. K. Sandberg, N. M. Fast, E. H. Palacios, G. Fennelly, J. Dobroszycki, P. Palumbo, A. Wiznia, R. M. Grant, N. Bhardwaj, M. G. Rosenberg, et al.
Selective Loss of Innate CD4+ V{alpha}24 Natural Killer T Cells in Human Immunodeficiency Virus Infection
J. Virol., June 27, 2002; 76(15): 7528 - 7534.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. E. Speiser, M. Colonna, M. Ayyoub, M. Cella, M. J. Pittet, P. Batard, D. Valmori, P. Guillaume, D. Lienard, J.-C. Cerottini, et al.
The Activatory Receptor 2B4 Is Expressed In Vivo by Human CD8+ Effector {alpha}{beta} T Cells
J. Immunol., December 1, 2001; 167(11): 6165 - 6170.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. D. Hislop, N. H. Gudgeon, M. F. C. Callan, C. Fazou, H. Hasegawa, M. Salmon, and A. B. Rickinson
EBV-Specific CD8+ T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function
J. Immunol., August 15, 2001; 167(4): 2019 - 2029.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Chen, P. Shankar, C. Lange, H. Valdez, P. R. Skolnik, L. Wu, N. Manjunath, and J. Lieberman
CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection
Blood, July 1, 2001; 98(1): 156 - 164.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. J. Campbell, S. Qin, D. Unutmaz, D. Soler, K. E. Murphy, M. R. Hodge, L. Wu, and E. C. Butcher
Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire
J. Immunol., June 1, 2001; 166(11): 6477 - 6482.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Ogawa, K. Tanaka, A. Ishii, Y. Nakamura, S. Kondo, K. Sugamura, S. Takano, M. Nakamura, and K. Nagata
A Novel Serum Protein That Is Selectively Produced by Cytotoxic Lymphocytes
J. Immunol., May 15, 2001; 166(10): 6404 - 6412.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Mollet, T.-S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran
Dynamics of HIV-Specific CD8+ T Lymphocytes with Changes in Viral Load
J. Immunol., August 1, 2000; 165(3): 1692 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. D. Santin, P. L. Hermonat, A. Ravaggi, S. Bellone, S. Pecorelli, J. J. Roman, G. P. Parham, and M. J. Cannon
Interleukin-10 Increases Th1 Cytokine Production and Cytotoxic Potential in Human Papillomavirus-Specific CD8+ Cytotoxic T Lymphocytes
J. Virol., May 15, 2000; 74(10): 4729 - 4737.
[Abstract] [Full Text]

Home page
 J. Exp. Med.Home page
S. Reignat, G. J.M. Webster, D. Brown, G. S. Ogg, A. King, S. L. Seneviratne, G. Dusheiko, R. Williams, M. K. Maini, and A. Bertoletti
Escaping High Viral Load Exhaustion: CD8 Cells with Altered Tetramer Binding in Chronic Hepatitis B Virus Infection
J. Exp. Med., May 6, 2002; 195(9): 1089 - 1101.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.