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Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455; and
Department of Laboratory Medicine and Microbiology, University of Washington, Seattle, WA 98195
CD4+ T cells are important for resistance to infection with Salmonella typhimurium. However, the Ag specificity of this T cell response is unknown. Here, we demonstrate that a significant fraction of Salmonella-specific CD4+ T cells respond to the flagellar filament protein, FliC, and that this Ag has the capacity to protect naive mice from lethal Salmonella infection. To characterize this Ag-specific response further, we generated FliC-specific CD4+ T cell clones from mice that had resolved infection with an attenuated strain of Salmonella. These clones were found to respond to an epitope from a constant region of FliC, enabling them to cross-react with flagellar proteins expressed by a number of distinct Salmonella serovars.
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U. Yrlid, M. Svensson, A. Hakansson, B. J. Chambers, H.-G. Ljunggren, and M. J. Wick In Vivo Activation of Dendritic Cells and T Cells during Salmonella enterica Serovar Typhimurium Infection Infect. Immun., September 1, 2001; 69(9): 5726 - 5735. [Abstract] [Full Text] [PDF]
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D. Bumann In Vivo Visualization of Bacterial Colonization, Antigen Expression, and Specific T-Cell Induction following Oral Administration of Live Recombinant Salmonella enterica Serovar Typhimurium Infect. Immun., July 1, 2001; 69(7): 4618 - 4626. [Abstract] [Full Text] [PDF]
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A. C. Kirby, U. Yrlid, M. Svensson, and M. J. Wick Differential Involvement of Dendritic Cell Subsets During Acute Salmonella Infection J. Immunol., June 1, 2001; 166(11): 6802 - 6811. [Abstract] [Full Text] [PDF]
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