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The Journal of Immunology, 2000, 164: 986-993.
Copyright © 2000 by The American Association of Immunologists

Characterization of CD4+ T Cell Responses During Natural Infection with Salmonella typhimurium1

Stephen J. McSorley2,*, Brad T. Cookson{dagger} and Marc K. Jenkins*

* Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455; and {dagger} Department of Laboratory Medicine and Microbiology, University of Washington, Seattle, WA 98195

CD4+ T cells are important for resistance to infection with Salmonella typhimurium. However, the Ag specificity of this T cell response is unknown. Here, we demonstrate that a significant fraction of Salmonella-specific CD4+ T cells respond to the flagellar filament protein, FliC, and that this Ag has the capacity to protect naive mice from lethal Salmonella infection. To characterize this Ag-specific response further, we generated FliC-specific CD4+ T cell clones from mice that had resolved infection with an attenuated strain of Salmonella. These clones were found to respond to an epitope from a constant region of FliC, enabling them to cross-react with flagellar proteins expressed by a number of distinct Salmonella serovars.




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