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Comparative Contribution of CD1 on the Development of CD4⁺ and CD8⁺ T Cell Compartments¹

Gwen Knapp Center for Lupus and Immunology Research, Committee on Immunology, and Department of Pathology, University of Chicago, Chicago, IL 60637

CD1 molecules are MHC class I-like glycoproteins whose expression is essential for the development of a unique subset of T cells, the NK T cells. To evaluate to what extent CD1 contributes to the development of CD4⁺ and CD8⁺ T cells, we generated CD1^oII^o and CD1^oTAP^o mice and compared the generation of T cells in these double-mutant mice and II^o or TAP^o mice. FACS analysis showed that the number of CD4⁺ T cells in CD1^oII^o mice was reduced significantly compared with the corresponding population in II^o mice. Both CD4⁺ NK1.1⁺ and the CD4⁺ NK1.1^- population were reduced in CD1^oII^o mice, suggesting that CD1 can select not only CD4⁺ NK1.1⁺ T cells but also some NK1.1^- CD4⁺ T cells. Functional analysis showed that the residual CD4⁺ cells in CD1^oII^o can secrete large amounts of IFN- and a significant amount of IL-4 during primary stimulation with anti-CD3, suggesting that this population may be enriched for NK T cells restricted by other class I molecules. In contrast to the CD4⁺ population, no significant differences in the CD8⁺ T cell compartment can be detected between TAP^o and CD1^oTAP^o mice in all lymphoid tissues tested, including intestinal intraepithelial lymphocytes. Our data suggest that, unlike other MHC class I molecules, CD1 does not contribute in a major way to the development of CD8⁺ T cells.

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