HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wang, B. Articles by Wang, C.-R. Search for Related Content PubMed PubMed Citation Articles by Wang, B. Articles by Wang, C.-R.

Comparative Contribution of CD1 on the Development of CD4⁺ and CD8⁺ T Cell Compartments¹

Gwen Knapp Center for Lupus and Immunology Research, Committee on Immunology, and Department of Pathology, University of Chicago, Chicago, IL 60637

CD1 molecules are MHC class I-like glycoproteins whose expression is essential for the development of a unique subset of T cells, the NK T cells. To evaluate to what extent CD1 contributes to the development of CD4⁺ and CD8⁺ T cells, we generated CD1^oII^o and CD1^oTAP^o mice and compared the generation of T cells in these double-mutant mice and II^o or TAP^o mice. FACS analysis showed that the number of CD4⁺ T cells in CD1^oII^o mice was reduced significantly compared with the corresponding population in II^o mice. Both CD4⁺ NK1.1⁺ and the CD4⁺ NK1.1^- population were reduced in CD1^oII^o mice, suggesting that CD1 can select not only CD4⁺ NK1.1⁺ T cells but also some NK1.1^- CD4⁺ T cells. Functional analysis showed that the residual CD4⁺ cells in CD1^oII^o can secrete large amounts of IFN- and a significant amount of IL-4 during primary stimulation with anti-CD3, suggesting that this population may be enriched for NK T cells restricted by other class I molecules. In contrast to the CD4⁺ population, no significant differences in the CD8⁺ T cell compartment can be detected between TAP^o and CD1^oTAP^o mice in all lymphoid tissues tested, including intestinal intraepithelial lymphocytes. Our data suggest that, unlike other MHC class I molecules, CD1 does not contribute in a major way to the development of CD8⁺ T cells.

This article has been cited by other articles:

				L. J. Kobrynski, A. O. Sousa, A. J. Nahmias, and F. K. Lee Cutting Edge: Antibody Production to Pneumococcal Polysaccharides Requires CD1 Molecules and CD8+ T Cells J. Immunol., February 15, 2005; 174(4): 1787 - 1790. [Abstract] [Full Text] [PDF]

				H. Xu, T. Chun, A. Colmone, H. Nguyen, and C.-R. Wang Expression of CD1d Under the Control of a MHC Class Ia Promoter Skews the Development of NKT Cells, But Not CD8+ T Cells J. Immunol., October 15, 2003; 171(8): 4105 - 4112. [Abstract] [Full Text] [PDF]

				T. Ulrichs, D. B. Moody, E. Grant, S. H. E. Kaufmann, and S. A. Porcelli T-Cell Responses to CD1-Presented Lipid Antigens in Humans with Mycobacterium tuberculosis Infection Infect. Immun., June 1, 2003; 71(6): 3076 - 3087. [Abstract] [Full Text] [PDF]

				L. Sfondrini, D. Besusso, M. T. Zoia, M. Rodolfo, A. M. Invernizzi, M. Taniguchi, T. Nakayama, M. P. Colombo, S. Menard, and A. Balsari Absence of the CD1 Molecule Up-Regulates Antitumor Activity Induced by CpG Oligodeoxynucleotides in Mice J. Immunol., July 1, 2002; 169(1): 151 - 158. [Abstract] [Full Text] [PDF]

				S.-H. Park, A. Weiss, K. Benlagha, T. Kyin, L. Teyton, and A. Bendelac The Mouse Cd1d-Restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families J. Exp. Med., April 16, 2001; 193(8): 893 - 904. [Abstract] [Full Text] [PDF]

				B. Wang, T. Chun, I. C. Rulifson, M. Exley, S. P. Balk, and C.-R. Wang Human CD1d Functions as a Transplantation Antigen and a Restriction Element in Mice J. Immunol., March 15, 2001; 166(6): 3829 - 3836. [Abstract] [Full Text] [PDF]