| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201
Although resting B cells as APC are tolerogenic for naive T cells
in vivo, we show here that they can provide all the costimulatory
signals necessary for naive T cell proliferation in vivo and in vitro.
In the absence of an activating signal through the B cell Ag receptor,
T cell proliferation after Ag recognition on resting B cells depends on
CD40 expression on the B cells, implying that naive T cells use the
membrane-bound cytokine, CD40 ligand (CD154), to induce the
costimulatory signals that they need. Induction of B7-1 (CD80) and
increased or sustained expression of CD44H, ICAM-1 (CD54), and B7-2
(CD86) are dependent on the interaction of CD40 ligand with CD40.
Transient expression (12 h) of B7-2 is T cell- and peptide
Ag-dependent, but CD40-independent. Only sustained (
24 h) expression
of B7-2 and perhaps increased expression of ICAM-1 could be shown to be
functionally important in this system. T cells cultured with
CD40-deficient B cells and peptide remain about as responsive as fresh
naive cells upon secondary culture with whole splenic APC. Therefore, B
cells, and perhaps other APC, may be tolerogenic not because they fail
to provide sufficient costimulation for T cell proliferation, but
because they are deficient in some later functions necessary for a
productive T cell response.
This article has been cited by other articles:
|
|
 |
|
  C. E. Ruby and A. D. Weinberg OX40-Enhanced Tumor Rejection and Effector T Cell Differentiation Decreases with Age J. Immunol., February 1, 2009; 182(3): 1481 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ding, L. Wang, J. Marroquin, and J. Yan Targeting of antigens to B cells augments antigen-specific T-cell responses and breaks immune tolerance to tumor-associated antigen MUC1 Blood, October 1, 2008; 112(7): 2817 - 2825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Carrillo, M. C. Puertas, A. Alba, R. M. Ampudia, X. Pastor, R. Planas, N. Riutort, N. Alonso, R. Pujol-Borrell, P. Santamaria, et al. Islet-infiltrating B-Cells in Nonobese Diabetic Mice Predominantly Target Nervous System Elements Diabetes, January 1, 2005; 54(1): 69 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Pollard, M. Arnush, P. Hultman, and D. H. Kono Costimulation Requirements of Induced Murine Systemic Autoimmune Disease J. Immunol., November 1, 2004; 173(9): 5880 - 5887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Palena, M. Zhu, J. Schlom, and K.-Y. Tsang Human B cells that hyperexpress a triad of costimulatory molecules via avipox-vector infection: an alternative source of efficient antigen-presenting cells Blood, July 1, 2004; 104(1): 192 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Munthe, A. Os, M. Zangani, and B. Bogen MHC-Restricted Ig V Region-Driven T-B Lymphocyte Collaboration: B Cell Receptor Ligation Facilitates Switch to IgG Production J. Immunol., June 15, 2004; 172(12): 7476 - 7484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gerloni, M. Rizzi, P. Castiglioni, and M. Zanetti T cell immunity using transgenic B lymphocytes PNAS, March 16, 2004; 101(11): 3892 - 3897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Coughlin, B. A. Vance, S. A. Grupp, and R. H. Vonderheide RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets: implications for pediatric immunotherapy Blood, March 15, 2004; 103(6): 2046 - 2054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Reyes-Moreno, J. Girouard, R. Lapointe, A. Darveau, and W. Mourad CD40/CD40 Homodimers Are Required for CD40-induced Phosphatidylinositol 3-Kinase-dependent Expression of B7.2 by Human B Lymphocytes J. Biol. Chem., February 27, 2004; 279(9): 7799 - 7806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. van Maurik, B. F. de St. Groth, K. J. Wood, and N. D. Jones Dependency of Direct Pathway CD4+ T Cells on CD40-CD154 Costimulation Is Determined by Nature and Microenvironment of Primary Contact with Alloantigen J. Immunol., February 15, 2004; 172(4): 2163 - 2170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wagner, H. Poeck, B. Jahrsdoerfer, S. Rothenfusser, D. Prell, B. Bohle, E. Tuma, T. Giese, J. W. Ellwart, S. Endres, et al. IL-12p70-Dependent Th1 Induction by Human B Cells Requires Combined Activation with CD40 Ligand and CpG DNA J. Immunol., January 15, 2004; 172(2): 954 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Clatza, L. C. Bonifaz, D. A. A. Vignali, and J. Moreno CD40-Induced Aggregation of MHC Class II and CD80 on the Cell Surface Leads to an Early Enhancement in Antigen Presentation J. Immunol., December 15, 2003; 171(12): 6478 - 6487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Chung, A. D. Wells, S. Adler, A. Jacob, L. A. Turka, and J. G. Monroe Incomplete Activation of CD4 T Cells by Antigen-Presenting Transitional Immature B Cells: Implications for Peripheral B and T Cell Responsiveness J. Immunol., August 15, 2003; 171(4): 1758 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lapointe, A. Bellemare-Pelletier, F. Housseau, J. Thibodeau, and P. Hwu CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells Cancer Res., June 1, 2003; 63(11): 2836 - 2843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Podojil and V. M. Sanders Selective Regulation of Mature IgG1 Transcription by CD86 and {beta}2-Adrenergic Receptor Stimulation J. Immunol., May 15, 2003; 170(10): 5143 - 5151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Phillips, T. G. Markees, J. P. Mordes, D. L. Greiner, and A. A. Rossini Blockade of CD40-Mediated Signaling Is Sufficient for Inducing Islet But Not Skin Transplantation Tolerance J. Immunol., March 15, 2003; 170(6): 3015 - 3023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Schmidt, J. Liu, T. Zhang, H. Y. Song, G. Sandusky, K. Mintze, R. J. Benschop, A. Glasebrook, D. D. Yang, and S. Na Enhanced B Cell Expansion, Survival, and Humoral Responses by Targeting Death Receptor 6 J. Exp. Med., January 6, 2003; 197(1): 51 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Kohm, A. Mozaffarian, and V. M. Sanders B Cell Receptor- and {beta}2-Adrenergic Receptor-Induced Regulation of B7-2 (CD86) Expression in B Cells J. Immunol., June 15, 2002; 168(12): 6314 - 6322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Snyder, X. Zhang, and L. J. Wysocki Negligible Class II MHC Presentation of B Cell Receptor-Derived Peptides by High Density Resting B Cells J. Immunol., April 15, 2002; 168(8): 3865 - 3873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. W. Greeley, D. J. Moore, H. Noorchashm, L. E. Noto, S. Y. Rostami, A. Schlachterman, H. K. Song, B. Koeberlein, C. F. Barker, and A. Naji Impaired Activation of Islet-Reactive CD4 T Cells in Pancreatic Lymph Nodes of B Cell-Deficient Nonobese Diabetic Mice J. Immunol., October 15, 2001; 167(8): 4351 - 4357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Gaglia, E. A. Greenfield, A. Mattoo, A. H. Sharpe, G. J. Freeman, and V. K. Kuchroo Intercellular Adhesion Molecule 1 Is Critical for Activation of CD28-Deficient T Cells J. Immunol., December 1, 2000; 165(11): 6091 - 6098. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
