| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
German Diabetes Research Institute, Heinrich-Heine-University, Düsseldorf, Germany
Human heat shock protein 60 (hsp60) elicits a potent
proinflammatory response in cells of the innate immune system and
therefore has been proposed as a danger signal of stressed or damaged
cells. We report here that macrophages of C3H/HeJ mice, carrying a
mutant Toll-like-receptor (Tlr) 4 are nonresponsive to hsp60. Both the
induction of TNF-
and NO formation were found dependent on a
functional Tlr4 whereas stimulation of macrophages by CpG DNA was Tlr4
independent. We conclude that Tlr4 mediates hsp60 signaling. This is
the first report of a putative endogenous ligand of the Tlr4
complex.
This article has been cited by other articles:
|
|
 |
|
  L. N. Henning, A. K. Azad, K. V. L. Parsa, J. E. Crowther, S. Tridandapani, and L. S. Schlesinger Pulmonary Surfactant Protein A Regulates TLR Expression and Activity in Human Macrophages J. Immunol., June 15, 2008; 180(12): 7847 - 7858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Riad, S. Jager, M. Sobirey, F. Escher, A. Yaulema-Riss, D. Westermann, A. Karatas, M. M. Heimesaat, S. Bereswill, D. Dragun, et al. Toll-Like Receptor-4 Modulates Survival by Induction of Left Ventricular Remodeling after Myocardial Infarction in Mice J. Immunol., May 15, 2008; 180(10): 6954 - 6961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cha, Z. Wang, L. Ao, N. Zou, C. A. Dinarello, A. Banerjee, D. A. Fullerton, and X. Meng Cytokines link toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia. Ann. Thorac. Surg., May 1, 2008; 85(5): 1678 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sandri, D. Rodriguez, E. Gomes, H. P. Monteiro, M. Russo, and A. Campa Is serum amyloid A an endogenous TLR4 agonist? J. Leukoc. Biol., May 1, 2008; 83(5): 1174 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhang, G. Ramesh, S. Uematsu, S. Akira, and W. B. Reeves TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity J. Am. Soc. Nephrol., May 1, 2008; 19(5): 923 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Simmonds and B. M. Foxwell Signalling, inflammation and arthritis: NF-{kappa}B and its relevance to arthritis and inflammation Rheumatology, May 1, 2008; 47(5): 584 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Biragyn, M. Coscia, K. Nagashima, M. Sanford, H. A. Young, and P. Olkhanud Murine {beta}-defensin 2 promotes TLR-4/MyD88-mediated and NF-{kappa}B-dependent atypical death of APCs via activation of TNFR2 J. Leukoc. Biol., April 1, 2008; 83(4): 998 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Caso, J. M. Pradillo, O. Hurtado, J. C. Leza, M. A. Moro, and I. Lizasoain Toll-Like Receptor 4 Is Involved in Subacute Stress-Induced Neuroinflammation and in the Worsening of Experimental Stroke Stroke, April 1, 2008; 39(4): 1314 - 1320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Frost and C. H. Lang Regulation of muscle growth by pathogen-associated molecules J Anim Sci, April 1, 2008; 86(14_suppl): E84 - E93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Torgler, S. E. Bongfen, J. C. Romero, A. Tardivel, M. Thome, and G. Corradin Sporozoite-Mediated Hepatocyte Wounding Limits Plasmodium Parasite Development via MyD88-Mediated NF-{kappa}B Activation and Inducible NO Synthase Expression J. Immunol., March 15, 2008; 180(6): 3990 - 3999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lehnardt, E. Schott, T. Trimbuch, D. Laubisch, C. Krueger, G. Wulczyn, R. Nitsch, and J. R. Weber A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS J. Neurosci., March 5, 2008; 28(10): 2320 - 2331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Kaczorowski, K. P. Mollen, R. Edmonds, and T. R. Billiar Early events in the recognition of danger signals after tissue injury J. Leukoc. Biol., March 1, 2008; 83(3): 546 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Osterloh, A. Veit, A. Gessner, B. Fleischer, and M. Breloer Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12 Int. Immunol., March 1, 2008; 20(3): 433 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Knapp, S. von Aulock, M. Leendertse, I. Haslinger, C. Draing, D. T. Golenbock, and T. van der Poll Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor J. Immunol., March 1, 2008; 180(5): 3478 - 3484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cohen, M. Stolarsky-Bennun, H. Amir-Kroll, R. Margalit, G. Nussbaum, M. Cohen-Sfady, M. Pevsner-Fischer, M. Fridkin, H. Bercovier, L. Eisenbach, et al. Pneumococcal Capsular Polysaccharide Is Immunogenic When Present on the Surface of Macrophages and Dendritic Cells: TLR4 Signaling Induced by a Conjugate Vaccine or by Lipopolysaccharide Is Conducive J. Immunol., February 15, 2008; 180(4): 2409 - 2418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Timmers, J. P.G. Sluijter, J. K. van Keulen, I. E. Hoefer, M. G.J. Nederhoff, M.-J. Goumans, P. A. Doevendans, C. J.A. van Echteld, J. A. Joles, P. H. Quax, et al. Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction Circ. Res., February 1, 2008; 102(2): 257 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Mollen, R. M. Levy, J. M. Prince, R. A. Hoffman, M. J. Scott, D. J. Kaczorowski, R. Vallabhaneni, Y. Vodovotz, and T. R. Billiar Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells J. Leukoc. Biol., January 1, 2008; 83(1): 80 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kettner, F. Kalthoff, P. Graf, E. Priller, F. Kricek, I. Lindley, and T. Schweighoffer EWI-2/CD316 Is an Inducible Receptor of HSPA8 on Human Dendritic Cells Mol. Cell. Biol., November 1, 2007; 27(21): 7718 - 7726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Levy, K. P. Mollen, J. M. Prince, D. J. Kaczorowski, R. Vallabhaneni, S. Liu, K. J. Tracey, M. T. Lotze, D. J. Hackam, M. P. Fink, et al. Systemic inflammation and remote organ injury following trauma require HMGB1 Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1538 - R1544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lin, S. C. Kim, Y. Wang, S. Gupta, B. Davis, S. I. Simon, G. Torre-Amione, and A. A. Knowlton HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2238 - H2247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Peng, G. Han, H. Shao, Y. Wang, H. J. Kaplan, and D. Sun Characterization of IL-17+ Interphotoreceptor Retinoid-Binding Protein-Specific T Cells in Experimental Autoimmune Uveitis Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4153 - 4161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Gondokaryono, H. Ushio, F. Niyonsaba, M. Hara, H. Takenaka, S. T. M. Jayawardana, S. Ikeda, K. Okumura, and H. Ogawa The extra domain A of fibronectin stimulates murine mast cells via Toll-like receptor 4 J. Leukoc. Biol., September 1, 2007; 82(3): 657 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Goldberg, M. Parolini, B. Y. Chin, E. Czismadia, L. E. Otterbein, F. H. Bach, and H. Wang Toll-like receptor 4 suppression leads to islet allograft survival FASEB J, September 1, 2007; 21(11): 2840 - 2848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Figueiredo, P. L. Fernandez, D. S. Mourao-Sa, B. N. Porto, F. F. Dutra, L. S. Alves, M. F. Oliveira, P. L. Oliveira, A. V. Graca-Souza, and M. T. Bozza Characterization of Heme as Activator of Toll-like Receptor 4 J. Biol. Chem., July 13, 2007; 282(28): 20221 - 20229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. LaRosa, A. H. Rahman, and L. A. Turka The Innate Immune System in Allograft Rejection and Tolerance J. Immunol., June 15, 2007; 178(12): 7503 - 7509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gupta and A. A. Knowlton HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H3052 - H3056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kim, M. A. Kim, I.-H. Cho, M. S. Kim, S. Lee, E.-K. Jo, S.-Y. Choi, K. Park, J. S. Kim, S. Akira, et al. A Critical Role of Toll-like Receptor 2 in Nerve Injury-induced Spinal Cord Glial Cell Activation and Pain Hypersensitivity J. Biol. Chem., May 18, 2007; 282(20): 14975 - 14983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-Y. Wang, J. Facciponte, X. Chen, J. R. Subjeck, and E. A. Repasky Scavenger Receptor-A Negatively Regulates Antitumor Immunity Cancer Res., May 15, 2007; 67(10): 4996 - 5002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Chaudhuri, M. K. B. Whyte, and I. Sabroe Reducing the Toll of Inflammatory Lung Disease Chest, May 1, 2007; 131(5): 1550 - 1556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tarang, A. Sodhi, and P. Chauhan Differential expression of Toll-like receptors in murine peritoneal macrophages in vitro on treatment with cisplatin Int. Immunol., May 1, 2007; 19(5): 635 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Shamaei-Tousi, J. P. Halcox, and B. Henderson Stressing the obvious? Cell stress and cell stress proteins in cardiovascular disease Cardiovasc Res, April 1, 2007; 74(1): 19 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Caso, J. M. Pradillo, O. Hurtado, P. Lorenzo, M. A. Moro, and I. Lizasoain Toll-Like Receptor 4 Is Involved in Brain Damage and Inflammation After Experimental Stroke Circulation, March 27, 2007; 115(12): 1599 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Winkler, D. Ghadimi, J. Schrezenmeir, and J.-P. Kraehenbuhl Molecular and Cellular Basis of Microflora-Host Interactions J. Nutr., March 1, 2007; 137(3): 756S - 772S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Osterloh, U. Kalinke, S. Weiss, B. Fleischer, and M. Breloer Synergistic and Differential Modulation of Immune Responses by Hsp60 and Lipopolysaccharide J. Biol. Chem., February 16, 2007; 282(7): 4669 - 4680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. I. Maratheftis, E. Andreakos, H. M. Moutsopoulos, and M. Voulgarelis Toll-like Receptor-4 Is Up-Regulated in Hematopoietic Progenitor Cells and Contributes to Increased Apoptosis in Myelodysplastic Syndromes Clin. Cancer Res., February 15, 2007; 13(4): 1154 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pevsner-Fischer, V. Morad, M. Cohen-Sfady, L. Rousso-Noori, A. Zanin-Zhorov, S. Cohen, I. R. Cohen, and D. Zipori Toll-like receptors and their ligands control mesenchymal stem cell functions Blood, February 15, 2007; 109(4): 1422 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-F. Tsan and Baochong Gao Review: Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors Innate Immunity, February 1, 2007; 13(1): 6 - 14. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Cao, A. Castrillo, P. Tontonoz, F. Re, and G. I. Byrne Chlamydia pneumoniae-Induced Macrophage Foam Cell Formation Is Mediated by Toll-Like Receptor 2 Infect. Immun., February 1, 2007; 75(2): 753 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Ramesh, S. R. Kimball, L. S. Jefferson, and W. B. Reeves Endotoxin and cisplatin synergistically stimulate TNF-{alpha} production by renal epithelial cells Am J Physiol Renal Physiol, February 1, 2007; 292(2): F812 - F819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Lasarte, N. Casares, M. Gorraiz, S. Hervas-Stubbs, L. Arribillaga, C. Mansilla, M. Durantez, D. Llopiz, P. Sarobe, F. Borras-Cuesta, et al. The Extra Domain A from Fibronectin Targets Antigens to TLR4-Expressing Cells and Induces Cytotoxic T Cell Responses In Vivo J. Immunol., January 15, 2007; 178(2): 748 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suganami, K. Tanimoto-Koyama, J. Nishida, M. Itoh, X. Yuan, S. Mizuarai, H. Kotani, S. Yamaoka, K. Miyake, S. Aoe, et al. Role of the Toll-like Receptor 4/NF-{kappa}B Pathway in Saturated Fatty Acid-Induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages Arterioscler. Thromb. Vasc. Biol., January 1, 2007; 27(1): 84 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sakata, J.-W. Dong, J. G. Vallejo, C.-H. Huang, J. S. Baker, K. J. Tracey, O. Tacheuchi, S. Akira, and D. L. Mann Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H503 - H509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Boyd, S. Mathur, Y. Wang, R. M. Bateman, and K. R. Walley Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-{kappa}B dependent inflammatory response Cardiovasc Res, December 1, 2006; 72(3): 384 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G ROUTSIAS and A. G TZIOUFAS The Role of Chaperone Proteins in Autoimmunity Ann. N.Y. Acad. Sci., November 1, 2006; 1088(1): 52 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.E. den Hartog, S.A. Morre, and J.A. Land Chlamydia trachomatis-associated tubal factor subfertility: immunogenetic aspects and serological screening Hum. Reprod. Update, November 1, 2006; 12(6): 719 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Levy, J. M. Prince, R. Yang, K. P. Mollen, H. Liao, G. A. Watson, M. P. Fink, Y. Vodovotz, and T. R. Billiar Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4 Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R970 - R976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhu, H. Zhao, A. R. Graveline, E. S. Buys, U. Schmidt, K. D. Bloch, A. Rosenzweig, and W. Chao MyD88 and NOS2 are essential for Toll-like receptor 4-mediated survival effect in cardiomyocytes Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1900 - H1909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. K. Demedts, K. R. Bracke, T. Maes, G. F. Joos, and G. G. Brusselle Different Roles for Human Lung Dendritic Cell Subsets in Pulmonary Immune Defense Mechanisms Am. J. Respir. Cell Mol. Biol., September 1, 2006; 35(3): 387 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Kim, B. A. Butcher, C. W. Lee, S. Uematsu, S. Akira, and E. Y. Denkers Toxoplasma gondii Genotype Determines MyD88-Dependent Signaling in Infected Macrophages J. Immunol., August 15, 2006; 177(4): 2584 - 2591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Warger, N. Hilf, G. Rechtsteiner, P. Haselmayer, D. M. Carrick, H. Jonuleit, P. von Landenberg, H.-G. Rammensee, C. V. Nicchitta, M. P. Radsak, et al. Interaction of TLR2 and TLR4 Ligands with the N-terminal Domain of Gp96 Amplifies Innate and Adaptive Immune Responses J. Biol. Chem., August 11, 2006; 281(32): 22545 - 22553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Miyake Invited review: Roles for accessory molecules in microbial recognition by Toll-like receptors Innate Immunity, August 1, 2006; 12(4): 195 - 204. [Abstract] [PDF]
|
|
|
|
 |
|
 M. T. Borchers, N. L. Harris, S. C. Wesselkamper, M. Vitucci, and D. Cosman NKG2D ligands are expressed on stressed human airway epithelial cells Am J Physiol Lung Cell Mol Physiol, August 1, 2006; 291(2): L222 - L231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Equils, D. Lu, M. Gatter, S. S. Witkin, C. Bertolotto, M. Arditi, J. A. McGregor, C. F. Simmons, and C. J. Hobel Chlamydia Heat Shock Protein 60 Induces Trophoblast Apoptosis through TLR4 J. Immunol., July 15, 2006; 177(2): 1257 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Shimamoto, A. J. Chong, M. Yada, S. Shomura, H. Takayama, A. J. Fleisig, M. L. Agnew, C. R. Hampton, C. L. Rothnie, D. J. Spring, et al. Inhibition of Toll-like Receptor 4 With Eritoran Attenuates Myocardial Ischemia-Reperfusion Injury Circulation, July 4, 2006; 114(1_suppl): I-270 - I-274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Henderson, E. Allan, and A. R. M. Coates Stress Wars: the Direct Role of Host and Bacterial Molecular Chaperones in Bacterial Infection Infect. Immun., July 1, 2006; 74(7): 3693 - 3706. [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Hussain, D. Yang, D. Suki, K. Aldape, E. Grimm, and A. B. Heimberger The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses Neuro-oncol, July 1, 2006; 8(3): 261 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rallabhandi, J. Bell, M. S. Boukhvalova, A. Medvedev, E. Lorenz, M. Arditi, V. G. Hemming, J. C. G. Blanco, D. M. Segal, and S. N. Vogel Analysis of TLR4 Polymorphic Variants: New Insights into TLR4/MD-2/CD14 Stoichiometry, Structure, and Signaling J. Immunol., July 1, 2006; 177(1): 322 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Mohammad, M. Morran, B. Slotterbeck, D. W. Leaman, Y. Sun, H. v. Grafenstein, S.-C. Hong, and M. F. McInerney Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse Int. Immunol., July 1, 2006; 18(7): 1101 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Tipping Toll-Like Receptors: The Interface between Innate and Adaptive Immunity J. Am. Soc. Nephrol., July 1, 2006; 17(7): 1769 - 1771. [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, I. Sabroe, J. D. Hasday, and S. N. Vogel Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease Innate Immunity, June 1, 2006; 12(3): 133 - 150. [Abstract] [PDF]
|
|
|
|
|
|
M. F. Roelofs, W. C. Boelens, L. A. B. Joosten, S. Abdollahi-Roodsaz, J. Geurts, L. U. Wunderink, B. W. Schreurs, W. B. van den Berg, and T. R. D. J. Radstake Identification of Small Heat Shock Protein B8 (HSP22) as a Novel TLR4 Ligand and Potential Involvement in the Pathogenesis of Rheumatoid Arthritis. J. Immunol., |
