| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Molecular Microbiology and Immunology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90089
NK cells are a relatively rare cell population in peripheral
lymphoid organs but are abundant in the liver, raising questions as to
their function in immune responses to infections of this organ. To
investigate this, cell-mediated immunity to viral liver infection
induced by a type 5, replication-defective, adenovirus was examined. It
is shown that NK cells in the absence of T cells cause hepatocyte
apoptosis in virus-infected livers associated with an increase in liver
enzymes in the serum. Concomitantly, NK cells induce production of
IFN-
, inhibitable by their elimination before infection. NK cells
are shown to be necessary for optimal priming of virus-specific T
cells, assessed by delayed-type hypersensitivity response and CTL
activity, consistent with their ability to secrete IFN-. The
conclusion is drawn that NK cells mediate two important functions in
the liver: they induce cell death in the infected organ and
concomitantly stimulate the induction of T cell-mediated immunity by
release of IFN-.
This article has been cited by other articles:
|
|
 |
|
  M. N. Ajuebor, Y. Jin, G. L. Gremillion, R. M. Strieter, Q. Chen, and P. A. Adegboyega {gamma}{delta}T Cells Initiate Acute Inflammation and Injury in Adenovirus-Infected Liver via Cytokine-Chemokine Cross Talk J. Virol., October 1, 2008; 82(19): 9564 - 9576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Burt, G. Plitas, J. A. Stableford, H. M. Nguyen, Z. M. Bamboat, V. G. Pillarisetty, and R. P. DeMatteo CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis J. Leukoc. Biol., October 1, 2008; 84(4): 1039 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Golden-Mason, L Madrigal-Estebas, E McGrath, M J Conroy, E J Ryan, J E Hegarty, C O'Farrelly, and D G Doherty Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure Gut, August 1, 2008; 57(8): 1121 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhu, X. Huang, and Y. Yang Innate Immune Response to Adenoviral Vectors Is Mediated by both Toll-Like Receptor-Dependent and -Independent Pathways J. Virol., April 1, 2007; 81(7): 3170 - 3180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Polakos, J. C. Cornejo, D. A. Murray, K. O. Wright, J. J. Treanor, I. N. Crispe, D. J. Topham, and R. H. Pierce Kupffer Cell-Dependent Hepatitis Occurs during Influenza Infection Am. J. Pathol., April 1, 2006; 168(4): 1169 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kawamura, F. Aswad, M. Minagawa, S. Govindarajan, and G. Dennert P2X7 Receptors Regulate NKT Cells in Autoimmune Hepatitis J. Immunol., February 15, 2006; 176(4): 2152 - 2160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Fan, P. Yu, Y. Wang, Y. Wang, M. L. Fu, W. Liu, Y. Sun, and Y.-X. Fu NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors Blood, February 15, 2006; 107(4): 1342 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Storm, C. Bartholdy, M. R. Sorensen, J. P. Christensen, and A. R. Thomsen Perforin-Deficient CD8+ T Cells Mediate Fatal Lymphocytic Choriomeningitis despite Impaired Cytokine Production J. Virol., February 1, 2006; 80(3): 1222 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Cotter, A. K. Zaiss, and D. A. Muruve Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1 J. Virol., December 1, 2005; 79(23): 14622 - 14631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Delale, A. Paquin, C. Asselin-Paturel, M. Dalod, G. Brizard, E. E. M. Bates, P. Kastner, S. Chan, S. Akira, A. Vicari, et al. MyD88-Dependent and -Independent Murine Cytomegalovirus Sensing for IFN-{alpha} Release and Initiation of Immune Responses In Vivo J. Immunol., November 15, 2005; 175(10): 6723 - 6732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Biburger and G. Tiegs {alpha}-Galactosylceramide-Induced Liver Injury in Mice Is Mediated by TNF-{alpha} but Independent of Kupffer Cells J. Immunol., August 1, 2005; 175(3): 1540 - 1550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. McKallip, M. Fisher, U. Gunthert, A. K. Szakal, P. S. Nagarkatti, and M. Nagarkatti Role of CD44 and Its v7 Isoform in Staphylococcal Enterotoxin B-Induced Toxic Shock: CD44 Deficiency on Hepatic Mononuclear Cells Leads to Reduced Activation-Induced Apoptosis That Results in Increased Liver Damage Infect. Immun., January 1, 2005; 73(1): 50 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ahmad and F. Alvarez Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis J. Leukoc. Biol., October 1, 2004; 76(4): 743 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Muhlen, J. Schumann, F. Wittke, S. Stenger, N. van Rooijen, L. van Kaer, and G. Tiegs NK Cells, but Not NKT Cells, Are Involved in Pseudomonas aeruginosa Exotoxin A-Induced Hepatotoxicity in Mice J. Immunol., March 1, 2004; 172(5): 3034 - 3041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Herzer, C. S. Falk, J. Encke, S. T. Eichhorst, A. Ulsenheimer, B. Seliger, and P. H. Krammer Upregulation of Major Histocompatibility Complex Class I on Liver Cells by Hepatitis C Virus Core Protein via p53 and TAP1 Impairs Natural Killer Cell Cytotoxicity J. Virol., August 1, 2003; 77(15): 8299 - 8309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schumann, K. Muhlen, A. K. Kiemer, A. M. Vollmar, and G. Tiegs Parenchymal, But Not Leukocyte, TNF Receptor 2 Mediates T Cell-Dependent Hepatitis in Mice J. Immunol., February 15, 2003; 170(4): 2129 - 2137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Thomson, M. Nascimbeni, M. B. Havert, M. Major, S. Gonzales, H. Alter, S. M. Feinstone, K. K. Murthy, B. Rehermann, and T. J. Liang The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity J. Virol., December 20, 2002; 77(2): 862 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-G. Zhang, J. Xie, L. Xu, P. Yang, X. Xu, S. Sun, Y. Wang, D. T. Curiel, H.-C. Hsu, and J. D. Mountz Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver J. Virol., May 3, 2002; 76(11): 5692 - 5700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Thio, X. Gao, J. J. Goedert, D. Vlahov, K. E. Nelson, M. W. Hilgartner, S. J. O'Brien, P. Karacki, J. Astemborski, M. Carrington, et al. HLA-Cw*04 and Hepatitis C Virus Persistence J. Virol., April 16, 2002; 76(10): 4792 - 4797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-X. Liu, H. Nishida, J.-W. He, M. M. C. Lai, N. Feng, and G. Dennert Hepatitis C Virus Genotype 1b Core Protein Does Not Exert Immunomodulatory Effects on Virus-Induced Cellular Immunity J. Virol., February 1, 2002; 76(3): 990 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Peng, E. Falck-Pedersen, and K. B. Elkon Variation in Adenovirus Transgene Expression between BALB/c and C57BL/6 Mice Is Associated with Differences in Interleukin-12 and Gamma Interferon Production and NK Cell Activation J. Virol., May 15, 2001; 75(10): 4540 - 4550. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. J. Smyth, E. Cretney, K. Takeda, R. H. Wiltrout, L. M. Sedger, N. Kayagaki, H. Yagita, and K. Okumura Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Contributes to Interferon {{gamma}}-dependent Natural Killer Cell Protection from Tumor Metastasis J. Exp. Med., March 12, 2001; 193(6): 661 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-X. Liu, S. Govindarajan, S. Okamoto, and G. Dennert Fas-Mediated Apoptosis Causes Elimination of Virus-Specific Cytotoxic T Cells in the Virus-Infected Liver J. Immunol., March 1, 2001; 166(5): 3035 - 3041. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
