| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Laboratory of Mycobacteria, Division of Bacterial Products, Center for Biologics, Evaluation, and Research, Food and Drug Administration, Rockville, MD 20852; and
Veterinary Resource Branch, Comparative Pathology Section, National Institutes of Health, Rockville, MD 20852
Long-term survival of mice infected with Mycobacterium
tuberculosis is dependent upon IFN-
and T cells, but events in
early phases of the immune response are not well understood. In this
study, we describe a role for B cells during early immune responses to
infection with a clinical isolate of M. tuberculosis (CDC
1551). Following a low-dose infection with M. tuberculosis
CDC 1551, similar numbers of bacteria were detected in the lungs of
both B cell knockout (IgH 6-, BKO) and C57BL/6J
(wild-type) mice. However, despite comparable bacterial loads in the
lungs, less severe pulmonary granuloma formation and delayed
dissemination of bacteria from lungs to peripheral organs were observed
in BKO mice. BKO mice reconstituted with naive B cells, but not those
given M. tuberculosis-specific Abs, before infection
developed pulmonary granulomas and dissemination patterns similar to
wild-type animals. Further analysis of lung cell populations revealed
greater numbers of lymphocytes, especially CD8+ T cells,
macrophages, and neutrophils in wild-type and reconstituted mice than
in BKO mice. Thus, less severe lesion formation and delayed
dissemination of bacteria found in BKO mice were dependent on B cells,
not Abs, and were associated with altered cellular infiltrate to the
lungs. These observations demonstrate an important, previously
unappreciated, role for B cells during early immune responses to
M. tuberculosis infections.
This article has been cited by other articles:
|
|
 |
|
  P. J. Maglione, J. Xu, A. Casadevall, and J. Chan Fc{gamma} Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection J. Immunol., March 1, 2008; 180(5): 3329 - 3338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rottman, E. Catherinot, P. Hochedez, J.-F. Emile, J.-L. Casanova, J.-L. Gaillard, and C. Soudais Importance of T Cells, Gamma Interferon, and Tumor Necrosis Factor in Immune Control of the Rapid Grower Mycobacterium abscessus in C57BL/6 Mice Infect. Immun., December 1, 2007; 75(12): 5898 - 5907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Maglione, J. Xu, and J. Chan B Cells Moderate Inflammatory Progression and Enhance Bacterial Containment upon Pulmonary Challenge with Mycobacterium tuberculosis J. Immunol., June 1, 2007; 178(11): 7222 - 7234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Tufariello, K. Mi, J. Xu, Y. C. Manabe, A. K. Kesavan, J. Drumm, K. Tanaka, W. R. Jacobs Jr., and J. Chan Deletion of the Mycobacterium tuberculosis Resuscitation-Promoting Factor Rv1009 Gene Results in Delayed Reactivation from Chronic Tuberculosis. Infect. Immun., May 1, 2006; 74(5): 2985 - 2995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Sato, T Nakai, N Tamura, S Okamoto, K Matsuoka, A Sakuraba, T Fukushima, T Uede, and T Hibi Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response Gut, September 1, 2005; 54(9): 1254 - 1262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rivera, O. Zaragoza, and A. Casadevall Antibody-Mediated Protection against Cryptococcus neoformans Pulmonary Infection Is Dependent on B Cells Infect. Immun., February 1, 2005; 73(2): 1141 - 1150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Cowley and K. L. Elkins CD4+ T Cells Mediate IFN-{gamma}-Independent Control of Mycobacterium tuberculosis Infection Both In Vitro and In Vivo J. Immunol., November 1, 2003; 171(9): 4689 - 4699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Burne-Taney, D. B. Ascon, F. Daniels, L. Racusen, W. Baldwin, and H. Rabb B Cell Deficiency Confers Protection from Renal Ischemia Reperfusion Injury J. Immunol., September 15, 2003; 171(6): 3210 - 3215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Pereira Arias-Bouda, S. Kuijper, A. Van Der Werf, L. N. Nguyen, H. M. Jansen, and A. H. J. Kolk Changes in Avidity and Level of Immunoglobulin G Antibodies to Mycobacterium tuberculosis in Sera of Patients Undergoing Treatment for Pulmonary Tuberculosis Clin. Vaccine Immunol., July 1, 2003; 10(4): 702 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. C. Turner, R. J. Basaraba, and I. M. Orme Immunopathogenesis of Pulmonary Granulomas in the Guinea Pig after Infection with Mycobacterium tuberculosis Infect. Immun., February 1, 2003; 71(2): 864 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Buendia, L. Del Rio, N. Ortega, J. Sanchez, M. C. Gallego, M. R. Caro, J. A. Navarro, F. Cuello, and J. Salinas B-Cell-Deficient Mice Show an Exacerbated Inflammatory Response in a Model of Chlamydophila abortus Infection Infect. Immun., December 1, 2002; 70(12): 6911 - 6918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Chackerian, J. M. Alt, T. V. Perera, C. C. Dascher, and S. M. Behar Dissemination of Mycobacterium tuberculosis Is Influenced by Host Factors and Precedes the Initiation of T-Cell Immunity Infect. Immun., August 1, 2002; 70(8): 4501 - 4509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Seiler, R. A. Schwendener, S. Bandermann, V. Brinkmann, L. Grode, S. H. E. Kaufmann, and P. Aichele Limited Mycobacterial Infection of the Liver as a Consequence of Its Microanatomical Structure Causing Restriction of Mycobacterial Growth to Professional Phagocytes Infect. Immun., December 1, 2001; 69(12): 7922 - 7926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Orme The search for new vaccines against tuberculosis J. Leukoc. Biol., July 1, 2001; 70(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gonzalez-Juarrero, O. C. Turner, J. Turner, P. Marietta, J. V. Brooks, and I. M. Orme Temporal and Spatial Arrangement of Lymphocytes within Lung Granulomas Induced by Aerosol Infection with Mycobacterium tuberculosis Infect. Immun., March 1, 2001; 69(3): 1722 - 1728. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
