| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Chemoattractant) Is an IFN-
- and Lipopolysaccharide- Inducible Glucocorticoid-Attenuated Response Gene Expressed in Lung and Other Tissues During Endotoxemia1
,
,,§
Departments of
*
Pediatrics,
Microbiology, Immunology, and Molecular Genetics, and
Medicine, and
§
Molecular Biology Institute, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095
A new murine chemokine was identified in a search for
glucocorticoid-attenuated response genes induced in the lung during
endotoxemia. The first 73 residues of the predicted mature peptide are
71% identical and 93% similar to human CXCL11/IFN-inducible T cell
chemoattractant (I-TAC) (alias ß-R1, H174, IFN-inducible protein
9 (IP-9), and SCYB9B). The murine chemokine has six additional residues
at the carboxyl terminus not present in human I-TAC. Identification of
this cDNA as murine CXCL11/I-TAC is supported by phylogenetic analysis
and by radiation hybrid mapping of murine I-TAC (gene symbol
Scyb11) to mouse chromosome 5 close to the genes for
monokine induced by IFN-
(MIG) and IP10. Murine I-TAC mRNA is
induced in RAW 264.7 macrophages by IFN- or LPS and is weakly
induced by IFN-ß. IFN- induction of murine I-TAC is markedly
enhanced by costimulation with LPS or IL-1ß in RAW cells and by
TNF- in both RAW cells and Swiss 3T3 fibroblasts. Murine I-TAC is
induced in multiple tissues during endoxemia, with strongest expression
in lung, heart, small intestine, and kidney, a pattern of tissue
expression different from those of MIG and IP10. Peak expression of
I-TAC message is delayed compared with IP10, both in lung after i.v.
LPS and in RAW 264.7 cells treated with LPS or with IFN-.
Pretreatment with dexamethasone strongly attenuates both
IFN--induced I-TAC expression in RAW cells and endotoxemia-induced
I-TAC expression in lung and small intestine. The structural and
regulatory similarities of murine and human I-TAC suggest that mouse
models will be useful for investigating the role of this chemokine in
human biology and disease.
This article has been cited by other articles:
|
|
 |
|
  J. Ehrchen, L. Steinmuller, K. Barczyk, K. Tenbrock, W. Nacken, M. Eisenacher, U. Nordhues, C. Sorg, C. Sunderkotter, and J. Roth Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes Blood, February 1, 2007; 109(3): 1265 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ericsson, K. Kotarsky, M. Svensson, M. Sigvardsson, and W. Agace Functional Characterization of the CCL25 Promoter in Small Intestinal Epithelial Cells Suggests a Regulatory Role for Caudal-Related Homeobox (Cdx) Transcription Factors J. Immunol., March 15, 2006; 176(6): 3642 - 3651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Widney, Y. Hu, A. K. Foreman-Wykert, K. C. Bui, T. T. Nguyen, B. Lu, C. Gerard, J. F. Miller, and J. B. Smith CXCR3 and Its Ligands Participate in the Host Response to Bordetella bronchiseptica Infection of the Mouse Respiratory Tract but Are Not Required for Clearance of Bacteria from the Lung Infect. Immun., January 1, 2005; 73(1): 485 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Sentman, S. K. Meadows, C. R. Wira, and M. Eriksson Recruitment of Uterine NK Cells: Induction of CXC Chemokine Ligands 10 and 11 in Human Endometrium by Estradiol and Progesterone J. Immunol., December 1, 2004; 173(11): 6760 - 6766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Smith and H. R. Herschman Targeted Identification of Glucocorticoid-attenuated Response Genes: In Vitro and in Vivo Models Proceedings of the ATS, November 1, 2004; 1(3): 275 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Marson, R. M. Lawn, and T. Mikita Oxidized Low Density Lipoprotein Blocks Lipopolysaccharide-induced Interferon {beta} Synthesis in Human Macrophages by Interfering with IRF3 Activation J. Biol. Chem., July 2, 2004; 279(27): 28781 - 28788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Johnston, C. H. Kim, D. Soler, M. Emoto, and E. C. Butcher Differential Chemokine Responses and Homing Patterns of Murine TCR{alpha}{beta} NKT Cell Subsets J. Immunol., September 15, 2003; 171(6): 2960 - 2969. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Kallapur, A. H. Jobe, M. Ikegami, and C. J. Bachurski Increased IP-10 and MIG Expression after Intra-amniotic Endotoxin in Preterm Lamb Lung Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 779 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Smith, T. T. Nguyen, H. J. Hughes, H. R. Herschman, D. P. Widney, K. C. Bui, and L. E. Rovai Glucocorticoid-attenuated response genes induced in the lung during endotoxemia Am J Physiol Lung Cell Mol Physiol, September 1, 2002; 283(3): L636 - L647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Meraro, M. Gleit-Kielmanowicz, H. Hauser, and B.-Z. Levi IFN-Stimulated Gene 15 Is Synergistically Activated Through Interactions Between the Myelocyte/Lymphocyte-Specific Transcription Factors, PU.1, IFN Regulatory Factor-8/IFN Consensus Sequence Binding Protein, and IFN Regulatory Factor-4: Characterization of a New Subtype of IFN-Stimulated Response Element J. Immunol., June 15, 2002; 168(12): 6224 - 6231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Dufour, M. Dziejman, M. T. Liu, J. H. Leung, T. E. Lane, and A. D. Luster IFN-{gamma}-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking J. Immunol., April 1, 2002; 168(7): 3195 - 3204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, B. A. Luxon, A. Casola, R. P. Garofalo, M. Jamaluddin, and A. R. Brasier Expression of Respiratory Syncytial Virus-Induced Chemokine Gene Networks in Lower Airway Epithelial Cells Revealed by cDNA Microarrays J. Virol., October 1, 2001; 75(19): 9044 - 9058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhang, M. A. Thornton, M. A. Kowalska, B. S. Sachis, M. Feldman, M. Poncz, S. E. McKenzie, and M. P. Reilly Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus Blood, August 1, 2001; 98(3): 610 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Cox, C.-H. Jenh, W. Gonsiorek, J. Fine, S. K. Narula, P. J. Zavodny, and R. W. Hipkin Human Interferon-Inducible 10-kDa Protein and Human Interferon-Inducible T Cell {alpha} Chemoattractant Are Allotopic Ligands for Human CXCR3: Differential Binding to Receptor States Mol. Pharmacol., April 1, 2001; 59(4): 707 - 715. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
