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Receptor IIB on Follicular Dendritic Cells Regulates the B Cell Recall Response1
Departments of
*
Microbiology and Immunology and
Anatomy, Division of Immunobiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298;
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, NY 10021; and
§
Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107
Generation of the B cell recall response appears to involve
interaction of Ag, in the form of an immune complex (IC) trapped on
follicular dendritic cells (FDCs), with germinal center (GC) B cells.
Thus, the expression of receptors on FDC and B cells that interact with
ICs could be critical to the induction of an optimal recall response.
FDCs in GCs, but not in primary follicles, express high levels of the
IgG Fc receptor Fc
RIIB. This regulated expression of FcRIIB on
FDC and its relation to recall Ab responses were examined both in vitro
and in vivo. Trapping of IC in spleen and lymph nodes of
FcRII-/- mice was significantly reduced
compared with that in wild-type controls. Addition of ICs to cultures
of Ag-specific T and B cells elicited pronounced Ab responses only in
the presence of FDCs. However, FDCs derived from
FcRIIB-/- mice supported only low level Ab
production in this situation. Similarly, when
FcRIIB-/- mice were transplanted with
wild-type Ag-specific T and B cells and challenged with specific Ag,
the recall responses were significantly depressed compared with those
of controls with wild-type FDC. These results substantiate the
hypothesis that FcRIIB expression on FDCs in GCs is important for
FDCs to retain ICs and to mediate the conversion of ICs to a highly
immunogenic form and for the generation of strong recall
responses.
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