| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
*
Neurology and
Animal Resources, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
Female SJL mice preferentially mount Th1-immune responses and are susceptible to the active induction of experimental allergic encephalomyelitis. By contrast, young adult male SJL are resistant to experimental allergic encephalomyelitis due to an APC-dependent induction of Th2 cells. The basis for this gender-dependent differential T cell induction was examined by analysis of macrophage APC cytokine secretion during T cell activation. APC derived from females secrete IL-12, but not IL-10, during T cell activation. By contrast, APC derived from males secrete IL-10, but not IL-12, during T cell activation. Activation of T cells with APC derived from the opposite sex demonstrated that these cytokines were derived from the respective APC populations. Furthermore, inhibition of IL-10, but not TGF-ß, during T cell activation resulted in the secretion of IL-12 by male-derived APC. APC from naive male mice, in which IL-10 was reduced in vivo before isolation, also secrete IL-12, demonstrating altered APC cytokine secretion was due to an environment high in IL-10 before Ag encounter. Finally, APC derived from castrated male mice preferentially secrete IL-12 during T cell activation. These data demonstrate a link between gonadal hormones and APC activity and suggest that these hormones alter the APC, thereby influencing cytokine secretion during initial T cell activation.
This article has been cited by other articles:
|
|
 |
|
  S. E. Dunn, S. S. Ousman, R. A. Sobel, L. Zuniga, S. E. Baranzini, S. Youssef, A. Crowell, J. Loh, J. Oksenberg, and L. Steinman Peroxisome proliferator-activated receptor (PPAR){alpha} expression in T cells mediates gender differences in development of T cell-mediated autoimmunity J. Exp. Med., February 19, 2007; 204(2): 321 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J J Corrales, M Almeida, R Burgo, M T Mories, J M Miralles, and A Orfao Androgen-replacement therapy depresses the ex vivo production of inflammatory cytokines by circulating antigen-presenting cells in aging type-2 diabetic men with partial androgen deficiency. J. Endocrinol., June 1, 2006; 189(3): 595 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Sutherland, G. L. Goldberg, M. V. Hammett, A. P. Uldrich, S. P. Berzins, T. S. Heng, B. R. Blazar, J. L. Millar, M. A. Malin, A. P. Chidgey, et al. Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade J. Immunol., August 15, 2005; 175(4): 2741 - 2753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Palaszynski, D. L. Smith, S. Kamrava, P. S. Burgoyne, A. P. Arnold, and R. R. Voskuhl A Yin-Yang Effect between Sex Chromosome Complement and Sex Hormones on the Immune Response Endocrinology, August 1, 2005; 146(8): 3280 - 3285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H. van den Broek, J. G. Damoiseaux, M. H De Baets, and R. M. Hupperts The influence of sex hormones on cytokines in multiple sclerosis and experimental autoimmune encephalomyelitis: a review Multiple Sclerosis, June 1, 2005; 11(3): 349 - 359. [Abstract] [PDF]
|
|
|
|
 |
|
 J. W. Peacock, S. K. Nordone, S. S. Jackson, H.-X. Liao, N. L. Letvin, A. G. Yafal, L. Gritz, G. P. Mazzara, B. F. Haynes, and H. F. Staats Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting J. Virol., December 1, 2004; 78(23): 13163 - 13172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Paharkova-Vatchkova, R. Maldonado, and S. Kovats Estrogen Preferentially Promotes the Differentiation of CD11c+ CD11bintermediate Dendritic Cells from Bone Marrow Precursors J. Immunol., February 1, 2004; 172(3): 1426 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Fillmore, E. P. Blankenhorn, J. F. Zachary, and C. Teuscher Adult Gonadal Hormones Selectively Regulate Sexually Dimorphic Quantitative Traits Observed in Experimental Allergic Encephalomyelitis Am. J. Pathol., January 1, 2004; 164(1): 167 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Dowdell, D. J. Cua, E. Kirkman, and S. A. Stohlman NK Cells Regulate CD4 Responses Prior to Antigen Encounter J. Immunol., July 1, 2003; 171(1): 234 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Stanberry, S. L. Spruance, A. L. Cunningham, D. I. Bernstein, A. Mindel, S. Sacks, S. Tyring, F. Y. Aoki, M. Slaoui, M. Denis, et al. Glycoprotein-D-Adjuvant Vaccine to Prevent Genital Herpes N. Engl. J. Med., November 21, 2002; 347(21): 1652 - 1661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Travi, Y. Osorio, P. C. Melby, B. Chandrasekar, L. Arteaga, and N. G. Saravia Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp. Infect. Immun., May 1, 2002; 70(5): 2288 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Spindler, L. Fang, M. L. Moore, G. N. Hirsch, C. C. Brown, and A. Kajon SJL/J Mice Are Highly Susceptible to Infection by Mouse Adenovirus Type 1 J. Virol., December 15, 2001; 75(24): 12039 - 12046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Bunn, P. J. Parsons, E. Kao, and R. R. Dietert Exposure to Lead during Critical Windows of Embryonic Development: Differential Immunotoxic Outcome Based on Stage of Exposure and Gender Toxicol. Sci., November 1, 2001; 64(1): 57 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Liva and R. R. Voskuhl Testosterone Acts Directly on CD4+ T Lymphocytes to Increase IL-10 Production J. Immunol., August 15, 2001; 167(4): 2060 - 2067. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
