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The Journal of Immunology, 2000, 164: 6113-6119.
Copyright © 2000 by The American Association of Immunologists

Immune Complex and Fc Receptor-Mediated Augmentation of Antigen Presentation for in Vivo Th Cell Responses1

Yuki Hamano*,{dagger}, Hisashi Arase*, Hiromitsu Saisho{dagger} and Takashi Saito2,*

* Department of Molecular Genetics, Chiba University Graduate School of Medicine; and {dagger} First Department of Internal Medicine, Chiba University School of Medicine, Chiba, Japan

It has recently been established that FcRs are involved in the triggering of type II and III inflammatory responses. Although FcR is not believed to be involved in the regulation of T cell function, the in vivo contribution of FcRs to T cell function still remains unclear. We analyzed in vivo responses of delayed-type hypersensitivity and proliferation of CD4+ T cells to Ags in FcR{gamma}-/- mice lacking the expression and function of Fc{gamma}RI, Fc{gamma}RIII, and Fc{epsilon}RI. We found that the delayed-type hypersensitivity response in FcR{gamma}-/- mice is significantly decreased compared with that in wild-type mice. Moreover, the secondary responses of proliferation and cytokine production as well as the Ab formation by CD4+ T cells from FcR{gamma}-/- mice to Ag and normal APCs were also reduced. In contrast, in vitro primary T cell proliferative responses upon stimulation with anti-TCR Ab or MLR as well as in vivo primary response against staphylococcus enterotoxin B administration were not different between T cells from FcR{gamma}-/- and wild-type mice. In addition, the Ag presentation function of APCs from unimmunized FcR{gamma}-/- mice was normal. On the other hand, Ab-deficient mice also revealed impaired T cell responses. These results demonstrate that the defective T cell responses in FcR{gamma}-/- mice were due to impaired Ag presentation during in vivo priming not to a defect in T cells. Therefore, they suggest that the FcRs on APCs mediate efficient priming of Th cell responses in vivo in an immune complex-dependent manner.




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