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CUTTING EDGE |
*
Institut National de la Santé et de la Recherche Médicale (INSERM) U395, Hôpital de Purpan, Toulouse, France;
Centre Hayem, INSERM U396, Hôpital Saint-Louis, Paris, France; and
Faculté de Médecine de Créteil, INSERM U448, Créteil, France
The nonpolymorphic soluble HLA-G1 (sHLA-G1) isoform has been reported to be secreted by trophoblast cells at the materno-fetal interface, suggesting that it may act as immunomodulator during pregnancy. In this paper, we report that affinity-purified ß2-microglobulin-associated sHLA-G1 triggered apoptosis in activated, but not resting CD8+ peripheral blood cells. We demonstrate by Western blotting that sHLA-G1 enhanced CD95 ligand expression in activated CD8+ cells. Cytotoxicity was inhibited by preincubation of the cells with a CD95 antagonist mAb (ZB4) or a soluble recombinant CD95-Fc, indicating that apoptosis is mediated through the CD95/CD95 ligand pathway. Finally, we show that such sHLA-G1-induced apoptosis depends on the interaction with CD8 molecules, with cell death being blocked by various CD8 mAbs.
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C. B. Bigger, B. Guerra, K. M. Brasky, G. Hubbard, M. R. Beard, B. A. Luxon, S. M. Lemon, and R. E. Lanford Intrahepatic Gene Expression during Chronic Hepatitis C Virus Infection in Chimpanzees J. Virol., December 15, 2004; 78(24): 13779 - 13792. [Abstract] [Full Text] [PDF]
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C. Menier, M. Rabreau, J.-C. Challier, M. Le Discorde, E. D. Carosella, and N. Rouas-Freiss Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis Blood, November 15, 2004; 104(10): 3153 - 3160. [Abstract] [Full Text] [PDF]
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S. A. McCracken, E. Gallery, and J. M. Morris Pregnancy-Specific Down-Regulation of NF-{kappa}B Expression in T Cells in Humans Is Essential for the Maintenance of the Cytokine Profile Required for Pregnancy Success J. Immunol., April 1, 2004; 172(7): 4583 - 4591. [Abstract] [Full Text] [PDF]
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M. T. Barel, M. Ressing, N. Pizzato, D. van Leeuwen, P. Le Bouteiller, F. Lenfant, and E. J. H. J. Wiertz Human Cytomegalovirus-Encoded US2 Differentially Affects Surface Expression of MHC Class I Locus Products and Targets Membrane-Bound, but Not Soluble HLA-G1 for Degradation J. Immunol., December 15, 2003; 171(12): 6757 - 6765. [Abstract] [Full Text] [PDF]
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S. Hue, R. C. Monteiro, S. Berrih-Aknin, and S. Caillat-Zucman Potential Role of NKG2D/MHC Class I-Related Chain A Interaction in Intrathymic Maturation of Single-Positive CD8 T Cells J. Immunol., August 15, 2003; 171(4): 1909 - 1917. [Abstract] [Full Text] [PDF]
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A. Ishitani, N. Sageshima, N. Lee, N. Dorofeeva, K. Hatake, H. Marquardt, and D. E. Geraghty Protein Expression and Peptide Binding Suggest Unique and Interacting Functional Roles for HLA-E, F, and G in Maternal-Placental Immune Recognition J. Immunol., August 1, 2003; 171(3): 1376 - 1384. [Abstract] [Full Text] [PDF]
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S. Fournel, S. Neichel, H. Dali, S. Farci, B. Maillere, J.-P. Briand, and S. Muller CD4+ T Cells from (New Zealand Black x New Zealand White)F1 Lupus Mice and Normal Mice Immunized Against Apoptotic Nucleosomes Recognize Similar Th Cell Epitopes in the C Terminus of Histone H3 J. Immunol., July 15, 2003; 171(2): 636 - 644. [Abstract] [Full Text] [PDF]
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 E H Kemp, R A Metcalfe, P F Watson, and A P Weetman HLA-G does not have a pathophysiological role in Graves' disease J. Clin. Pathol., June 1, 2003; 56(6): 475 - 477. [Abstract] [Full Text] [PDF]
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F. Lenfant, N. Pizzato, S. Liang, C. Davrinche, P. Le Bouteiller, and A. Horuzsko Induction of HLA-G-restricted human cytomegalovirus pp65 (UL83)-specific cytotoxic T lymphocytes in HLA-G transgenic mice J. Gen. Virol., January 1, 2003; 84(2): 307 - 317. [Abstract] [Full Text] [PDF]
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H. Wiendl, M. Mitsdoerffer, V. Hofmeister, J. Wischhusen, E. H. Weiss, J. Dichgans, H. Lochmuller, R. Hohlfeld, A. Melms, and M. Weller The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy Brain, January 1, 2003; 126(1): 176 - 185. [Abstract] [Full Text] [PDF]
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E. G. Olivares, R. Munoz, G. Tejerizo, M. J. Montes, F. Gomez-Molina, and A. C. Abadia-Molina Decidual Lymphocytes of Human Spontaneous Abortions Induce Apoptosis but Not Necrosis in JEG-3 Extravillous Trophoblast Cells Biol Reprod, October 1, 2002; 67(4): 1211 - 1217. [Abstract] [Full Text] [PDF]
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M.J.C. van Lierop, F. Wijnands, Y.W. Loke, P.M. Emmer, H.G.M. Lukassen, D.D.M. Braat, A. van der Meer, S. Mosselman, and I. Joosten Detection of HLA-G by a specific sandwich ELISA using monoclonal antibodies G233 and 56B Mol. Hum. Reprod., August 1, 2002; 8(8): 776 - 784. [Abstract] [Full Text] [PDF]
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 K. L. Audus, M. J. Soares, and J. S. Hunt Characteristics of the Fetal/Maternal Interface with Potential Usefulness in the Development of Future Immunological and Pharmacological Strategies J. Pharmacol. Exp. Ther., May 1, 2002; 301(2): 402 - 409. [Abstract] [Full Text] [PDF]
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H. Wiendl, M. Mitsdoerffer, V. Hofmeister, J. Wischhusen, A. Bornemann, R. Meyermann, E. H. Weiss, A. Melms, and M. Weller A Functional Role of HLA-G Expression in Human Gliomas: An Alternative Strategy of Immune Escape J. Immunol., May 1, 2002; 168(9): 4772 - 4780. [Abstract] [Full Text] [PDF]
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G. M. Spaggiari, P. Contini, R. Carosio, M. Arvigo, M. Ghio, D. Oddone, A. Dondero, M. R. Zocchi, F. Puppo, F. Indiveri, et al. Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily Blood, March 1, 2002; 99(5): 1706 - 1714. [Abstract] [Full Text] [PDF]
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C.L. Aldrich, M.D. Stephenson, T. Karrison, R.R. Odem, D.W. Branch, J.R. Scott, J.R. Schreiber, and C. Ober HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage Mol. Hum. Reprod., December 1, 2001; 7(12): 1167 - 1172. [Abstract] [Full Text] [PDF]
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O. Nohara, M. Kulka, R. E. Dery, F. L. Wills, N. S. Hirji, M. Gilchrist, and A. D. Befus Regulation of CD8 Expression in Mast Cells by Exogenous or Endogenous Nitric Oxide J. Immunol., November 15, 2001; 167(10): 5935 - 5939. [Abstract] [Full Text] [PDF]
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 N. Lila, N. Rouas-Freiss, J. Dausset, A. Carpentier, and E. D. Carosella Soluble HLA-G protein secreted by allo-specific CD4+ T cells suppresses the allo-proliferative response: A CD4+ T cell regulatory mechanism PNAS, September 19, 2001; (2001) 201407398. [Abstract] [Full Text] [PDF]
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 E. C. Ibrahim, N. Guerra, M.-J. T. Lacombe, E. Angevin, S. Chouaib, E. D. Carosella, A. Caignard, and P. Paul Tumor-specific Up-Regulation of the Nonclassical Class I HLA-G Antigen Expression in Renal Carcinoma Cancer Res., September 1, 2001; 61(18): 6838 - 6845. [Abstract] [Full Text] [PDF]
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 M. Urosevic, M. O. Kurrer, J. Kamarashev, B. Mueller, W. Weder, G. Burg, R. A. Stahel, R. Dummer, and A. Trojan Human Leukocyte Antigen G Up-Regulation in Lung Cancer Associates with High-Grade Histology, Human Leukocyte Antigen Class I Loss and Interleukin-10 Production Am. J. Pathol., September 1, 2001; 159(3): 817 - 824. [Abstract] [Full Text] [PDF]
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S. Aractingi, N. Briand, C. Le Danff, M. Viguier, H. Bachelez, L. Michel, L. Dubertret, and E. D. Carosella HLA-G and NK Receptor Are Expressed in Psoriatic Skin : A Possible Pathway for Regulating Infiltrating T Cells? Am. J. Pathol., July 1, 2001; 159(1): 71 - 77. [Abstract] [Full Text] [PDF]
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K.A. Pfeiffer, R. Fimmers, G. Engels, H. van der Ven, and K. van der Ven The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion Mol. Hum. Reprod., April 1, 2001; 7(4): 373 - 378. [Abstract] [Full Text] [PDF]
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S. Lefebvre, S. Berrih-Aknin, F. Adrian, P. Moreau, S. Poea, L. Gourand, J. Dausset, E. D. Carosella, and P. Paul A Specific Interferon (IFN)-stimulated Response Element of the Distal HLA-G Promoter Binds IFN-regulatory Factor 1 and Mediates Enhancement of This Nonclassical Class I Gene by IFN-beta J. Biol. Chem., February 23, 2001; 276(9): 6133 - 6139. [Abstract] [Full Text] [PDF]
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N. Lila, N. Rouas-Freiss, J. Dausset, A. Carpentier, and E. D. Carosella Soluble HLA-G protein secreted by allo-specific CD4+ T cells suppresses the allo-proliferative response: A CD4+ T cell regulatory mechanism PNAS, October 9, 2001; 98(21): 12150 - 12155. [Abstract] [Full Text] [PDF]
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N. Lila, C. Amrein, R. Guillemain, P. Chevalier, C. Latremouille, J.-N. Fabiani, J. Dausset, E. D. Carosella, and A. Carpentier Human Leukocyte Antigen-G Expression After Heart Transplantation Is Associated With a Reduced Incidence of Rejection Circulation, April 23, 2002; 105(16): 1949 - 1954. [Abstract] [Full Text] [PDF]
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