HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Astier, A. Articles by Rabourdin-Combe, C. Search for Related Content PubMed PubMed Citation Articles by Astier, A. Articles by Rabourdin-Combe, C.

Cutting Edge: CD46, a New Costimulatory Molecule for T Cells, That Induces p120^CBL and LAT Phosphorylation¹

Institut National de la Santé et de la Recherche Médicale Unité 503, Ecole Normale Superieure de Lyon, Lyon, France

The widely expressed transmembrane molecule CD46 is the complement regulatory receptor for C3b as well as the receptor for several pathogens. Beside its binding functions, CD46 is also able to transduce signals. We showed that CD46 aggregation on human T cells induces p120^CBL and linker for activation of T cells (LAT) phosphorylation. These two proteins are adaptor proteins known to regulate TCR signaling. p120^CBL is a complex adaptor protein involved in negatively regulating signaling events, whereas LAT is a transmembrane adaptor protein found in glycolipid-enriched microdomains essential for T cell activation. Therefore, we investigated if a CD46/TCR costimulation would affect T cell activation. Indeed, CD46/CD3 costimulation strongly promotes T cell proliferation. Therefore, we propose that CD46 acts as a potent costimulatory molecule for human T cells.

This article has been cited by other articles:

				S. Russell How polarity shapes the destiny of T cells J. Cell Sci., January 15, 2008; 121(2): 131 - 136. [Abstract] [Full Text] [PDF]

				J. Oliaro, A. Pasam, N. J. Waterhouse, K. A. Browne, M. J. Ludford-Menting, J. A. Trapani, and S. M. Russell Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation PNAS, December 5, 2006; 103(49): 18685 - 18690. [Abstract] [Full Text] [PDF]

				G. Meiffren, M. Flacher, O. Azocar, C. Rabourdin-Combe, and M. Faure Cutting Edge: Abortive Proliferation of CD46-Induced Tr1-Like Cells due to a Defective Akt/Survivin Signaling Pathway J. Immunol., October 15, 2006; 177(8): 4957 - 4961. [Abstract] [Full Text] [PDF]

				I. Bachelet, A. Munitz, D. Mankutad, and F. Levi-Schaffer Mast Cell Costimulation by CD226/CD112 (DNAM-1/Nectin-2): A NOVEL INTERFACE IN THE ALLERGIC PROCESS J. Biol. Chem., September 15, 2006; 281(37): 27190 - 27196. [Abstract] [Full Text] [PDF]

				K. Li, M. J. Feito, S. H. Sacks, and N. S. Sheerin CD46 (Membrane Cofactor Protein) Acts as a Human Epithelial Cell Receptor for Internalization of Opsonized Uropathogenic Escherichia coli J. Immunol., August 15, 2006; 177(4): 2543 - 2551. [Abstract] [Full Text] [PDF]

				J. Hakulinen and J. Keski-Oja ADAM10-mediated Release of Complement Membrane Cofactor Protein during Apoptosis of Epithelial Cells J. Biol. Chem., July 28, 2006; 281(30): 21369 - 21376. [Abstract] [Full Text] [PDF]

				S. Schneider-Schaulies and U. Dittmer Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression J. Gen. Virol., June 1, 2006; 87(6): 1423 - 1438. [Abstract] [Full Text] [PDF]

				W. Barchet, J. D. Price, M. Cella, M. Colonna, S. K. MacMillan, J. P. Cobb, P. A. Thompson, K. M. Murphy, J. P. Atkinson, and C. Kemper Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation Blood, February 15, 2006; 107(4): 1497 - 1504. [Abstract] [Full Text] [PDF]

				L. J. Plant and A.-B. Jonsson Type IV Pili of Neisseria gonorrhoeae Influence the Activation of Human CD4+ T Cells Infect. Immun., January 1, 2006; 74(1): 442 - 448. [Abstract] [Full Text] [PDF]

				A. Jimenez-Perianez, G. Ojeda, G. Criado, A. Sanchez, E. Pini, J. Madrenas, J. M. Rojo, and P. Portoles Complement regulatory protein Crry/p65-mediated signaling in T lymphocytes: role of its cytoplasmic domain and partitioning into lipid rafts J. Leukoc. Biol., December 1, 2005; 78(6): 1386 - 1396. [Abstract] [Full Text] [PDF]

				M. Iacobelli-Martinez, R. R. Nepomuceno, J. Connolly, and G. R. Nemerow CD46-Utilizing Adenoviruses Inhibit C/EBP{beta}-Dependent Expression of Proinflammatory Cytokines J. Virol., September 1, 2005; 79(17): 11259 - 11268. [Abstract] [Full Text] [PDF]

				J. D. Price, J. Schaumburg, C. Sandin, J. P. Atkinson, G. Lindahl, and C. Kemper Induction of a Regulatory Phenotype in Human CD4+ T Cells by Streptococcal M Protein J. Immunol., July 15, 2005; 175(2): 677 - 684. [Abstract] [Full Text] [PDF]

				M. Mizuno, C. L. Harris, N. Suzuki, S. Matsuo, and B. P. Morgan Expression of CD46 in Developing Rat Spermatozoa: Ultrastructural Localization and Utility as a Marker of the Various Stages of the Seminiferous Tubuli Biol Reprod, April 1, 2005; 72(4): 908 - 915. [Abstract] [Full Text] [PDF]

				A. P. Smith, C. Paolucci, G. Di Lullo, S. E. Burastero, F. Santoro, and P. Lusso Viral Replication-Independent Blockade of Dendritic Cell Maturation and Interleukin-12 Production by Human Herpesvirus 6 J. Virol., March 1, 2005; 79(5): 2807 - 2813. [Abstract] [Full Text] [PDF]

				M. Mizuno, C. L. Harris, P. M. Johnson, and B. P. Morgan Rat Membrane Cofactor Protein (MCP; CD46) Is Expressed Only in the Acrosome of Developing and Mature Spermatozoa and Mediates Binding to Immobilized Activated C3 Biol Reprod, October 1, 2004; 71(4): 1374 - 1383. [Abstract] [Full Text] [PDF]

				E. Avota, N. Muller, M. Klett, and S. Schneider-Schaulies Measles Virus Interacts with and Alters Signal Transduction in T-Cell Lipid Rafts J. Virol., September 1, 2004; 78(17): 9552 - 9559. [Abstract] [Full Text] [PDF]

				B. Crimeen-Irwin, S. Ellis, D. Christiansen, M. J. Ludford-Menting, J. Milland, M. Lanteri, B. E. Loveland, D. Gerlier, and S. M. Russell Ligand Binding Determines Whether CD46 Is Internalized by Clathrin-coated Pits or Macropinocytosis J. Biol. Chem., November 21, 2003; 278(47): 46927 - 46937. [Abstract] [Full Text] [PDF]

				A. Smith, F. Santoro, G. Di Lullo, L. Dagna, A. Verani, and P. Lusso Selective suppression of IL-12 production by human herpesvirus 6 Blood, October 15, 2003; 102(8): 2877 - 2884. [Abstract] [Full Text] [PDF]

				K. Bieback, E. Lien, I. M. Klagge, E. Avota, J. Schneider-Schaulies, W. P. Duprex, H. Wagner, C. J. Kirschning, V. ter Meulen, and S. Schneider-Schaulies Hemagglutinin Protein of Wild-Type Measles Virus Activates Toll-Like Receptor 2 Signaling J. Virol., July 29, 2002; 76(17): 8729 - 8736. [Abstract] [Full Text] [PDF]

				Y. Zaffran, O. Destaing, A. Roux, S. Ory, T. Nheu, P. Jurdic, C. Rabourdin-Combe, and A. L. Astier CD46/CD3 Costimulation Induces Morphological Changes of Human T Cells and Activation of Vav, Rac, and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase J. Immunol., December 15, 2001; 167(12): 6780 - 6785. [Abstract] [Full Text] [PDF]

				N. Inoue, A. Fukui, M. Nomura, M. Matsumoto, K. Toyoshima, and T. Seya A Novel Chicken Membrane-Associated Complement Regulatory Protein: Molecular Cloning and Functional Characterization J. Immunol., January 1, 2001; 166(1): 424 - 431. [Abstract] [Full Text] [PDF]

				M. J. Ludford-Menting, S. J. Thomas, B. Crimeen, L. J. Harris, B. E. Loveland, M. Bills, S. Ellis, and S. M. Russell A Functional Interaction between CD46 and DLG4. A ROLE FOR DLG4 IN EPITHELIAL POLARIZATION J. Biol. Chem., February 1, 2002; 277(6): 4477 - 4484. [Abstract] [Full Text] [PDF]