| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Immunology and Microbiology, Institute of Medical Biology, University of Southern Denmark, Odense University, Odense, Denmark; and
Statens Serum Institut, Copenhagen, Denmark
Lung surfactant protein-D (SP-D), a collectin mainly produced by alveolar type II cells, initiates the effector mechanisms of innate immunity on binding to microbial carbohydrates. A panel of mRNAs from human tissues was screened for SP-D mRNA by RT-PCR. The lung was the main site of synthesis, but transcripts were readily amplified from trachea, brain, testis, salivary gland, heart, prostate gland, kidney, and pancreas. Minor sites of synthesis were uterus, small intestine, placenta, mammary gland, and stomach. The sequence of SP-D derived from parotid gland mRNA was identical with that of pulmonary SP-D. mAbs were raised against SP-D, and one was used to locate SP-D in cells and tissues by immunohistochemistry. SP-D immunoreactivity was found in alveolar type II cells, Clara cells, on and within alveolar macrophages, in epithelial cells of large and small ducts of the parotid gland, sweat glands, and lachrymal glands, in epithelial cells of the gall bladder and intrahepatic bile ducts, and in exocrine pancreatic ducts. SP-D was also present in epithelial cells of the skin, esophagus, small intestine, and urinary tract, as well as in the collecting ducts of the kidney. SP-D is generally present on mucosal surfaces and not restricted to a subset of cells in the lung. The localization and functions of SP-D indicate that this collectin is the counterpart in the innate immune system of IgA in the adaptive immune system.
This article has been cited by other articles:
|
|
 |
|
  S. Matalon, K. Shrestha, M. Kirk, S. Waldheuser, B. McDonald, K. Smith, Z. Gao, A. Belaaouaj, and E. C. Crouch Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo FASEB J, May 1, 2009; 23(5): 1415 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Samten, J. C. Townsend, Z. Sever-Chroneos, V. Pasquinelli, P. F. Barnes, and Z. C. Chroneos An antibody against the surfactant protein A (SP-A)-binding domain of the SP-A receptor inhibits T cell-mediated immune responses to Mycobacterium tuberculosis J. Leukoc. Biol., July 1, 2008; 84(1): 115 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sahly, Y. Keisari, E. Crouch, N. Sharon, and I. Ofek Recognition of Bacterial Surface Polysaccharides by Lectins of the Innate Immune System and Its Contribution to Defense against Infection: the Case of Pulmonary Pathogens Infect. Immun., April 1, 2008; 76(4): 1322 - 1332. [Full Text] [PDF]
|
|
|
|
 |
|
 W. Motomura, T. Yoshizaki, K. Ohtani, T. Okumura, M. Fukuda, J. Fukuzawa, K. Mori, S.-J. Jang, N. Nomura, I. Yoshida, et al. Immunolocalization of a Novel Collectin CL-K1 in Murine Tissues J. Histochem. Cytochem., March 1, 2008; 56(3): 243 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. S. George, K. L. Goss, D. K. Meyerholz, F. S. Lamb, and J. M. Snyder Surfactant-Associated Protein A Provides Critical Immunoprotection in Neonatal Mice Infect. Immun., January 1, 2008; 76(1): 380 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Oberley, K. L. Goss, D. S. Hoffmann, K. A. Ault, T. L. Neff, K. H. Ramsey, and J. M. Snyder Regulation of surfactant protein D in the mouse female reproductive tract in vivo Mol. Hum. Reprod., December 1, 2007; 13(12): 863 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Brauer, C. Kindler, K. Jager, S. Sel, B. Nolle, U. Pleyer, M. Ochs, and F. P. Paulsen Detection of Surfactant Proteins A and D in Human Tear Fluid and the Human Lacrimal System Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 3945 - 3953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Kim, S.-S. Kim, K. W. Rha, C.-H. Kim, J. H. Cho, C.-H. Lee, J.-G. Lee, and J.-H. Yoon Expression and localization of surfactant proteins in human nasal epithelium Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L879 - L884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hansen, B. Lo, K. Evans, P. Neophytou, U. Holmskov, and J. R. Wright Surfactant Protein D Augments Bacterial Association but Attenuates Major Histocompatibility Complex Class II Presentation of Bacterial Antigens Am. J. Respir. Cell Mol. Biol., January 1, 2007; 36(1): 94 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ma, J. L. Simala-Grant, and D. E. Taylor Fucosylation in prokaryotes and eukaryotes Glycobiology, December 1, 2006; 16(12): 158R - 184R. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.A. Campbell, L. O'Hara, R.D. Catalano, A.M. Sharkey, T.C. Freeman, and M. H. Johnson Temporal expression profiling of the uterine luminal epithelium of the pseudo-pregnant mouse suggests receptivity to the fertilized egg is associated with complex transcriptional changes Hum. Reprod., October 1, 2006; 21(10): 2495 - 2513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Hartshorn, M. R. White, T. Tecle, U. Holmskov, and E. C. Crouch Innate Defense against Influenza A Virus: Activity of Human Neutrophil Defensins and Interactions of Defensins with Surfactant Protein D. J. Immunol., June 1, 2006; 176(11): 6962 - 6972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Sorensen, J. Madsen, K. Kejling, I. Tornoe, O. Nielsen, P. Townsend, F. Poulain, C. H. Nielsen, K. B. M. Reid, S. Hawgood, et al. Surfactant protein D is proatherogenic in mice Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2286 - H2294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Sorensen, J. v. B. Hjelmborg, K. O. Kyvik, M. Fenger, A. Hoj, C. Bendixen, T. I. A. Sorensen, and U. Holmskov Genetic and environmental influences of surfactant protein D serum levels Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L1010 - L1017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Lynch, K. A. Dawson, and S. Linse Detecting Cryptic Epitopes Created by Nanoparticles Sci. Signal., March 21, 2006; 2006(327): pe14 - pe14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Haczku, Y. Cao, G. Vass, S. Kierstein, P. Nath, E. N. Atochina-Vasserman, S. T. Scanlon, L. Li, D. E. Griswold, K. F. Chung, et al. IL-4 and IL-13 Form a Negative Feedback Circuit with Surfactant Protein-D in the Allergic Airway Response J. Immunol., March 15, 2006; 176(6): 3557 - 3565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Moran, W. Khamri, M. M. Walker, and M. R. Thursz Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide Innate Immunity, December 1, 2005; 11(6): 357 - 362. [Abstract] [PDF]
|
|
|
|
|
|
W. Khamri, A. P. Moran, M. L. Worku, Q. N. Karim, M. M. Walker, H. Annuk, J. A. Ferris, B. J. Appelmelk, P. Eggleton, K. B. M. Reid, et al. Variations in Helicobacter pylori Lipopolysaccharide To Evade the Innate Immune Component Surfactant Protein D Infect. Immun., November 1, 2005; 73(11): 7677 - 7686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Meschi, E. C. Crouch, P. Skolnik, K. Yahya, U. Holmskov, R. Leth-Larsen, I. Tornoe, T. Tecle, M. R. White, and K. L. Hartshorn Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication J. Gen. Virol., November 1, 2005; 86(11): 3097 - 3107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Jaspers, J. M. Ciencewicki, W. Zhang, L. E. Brighton, J. L. Carson, M. A. Beck, and M. C. Madden Diesel Exhaust Enhances Influenza Virus Infections in Respiratory Epithelial Cells Toxicol. Sci., June 1, 2005; 85(2): 990 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Kang, O. Nielsen, C. Fenger, G. Leslie, U. Holmskov, and K. B.M. Reid Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer Carcinogenesis, June 1, 2005; 26(6): 1129 - 1137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Palaniyar, H. Clark, J. Nadesalingam, M. J. Shih, S. Hawgood, and K. B. M. Reid Innate Immune Collectin Surfactant Protein D Enhances the Clearance of DNA by Macrophages and Minimizes Anti-DNA Antibody Generation J. Immunol., June 1, 2005; 174(11): 7352 - 7358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. White, E. Crouch, M. van Eijk, M. Hartshorn, L. Pemberton, I. Tornoe, U. Holmskov, and K. L. Hartshorn Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L831 - L840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Leth-Larsen, P. Garred, H. Jensenius, J. Meschi, K. Hartshorn, J. Madsen, I. Tornoe, H. O. Madsen, G. Sorensen, E. Crouch, et al. A Common Polymorphism in the SFTPD Gene Influences Assembly, Function, and Concentration of Surfactant Protein D J. Immunol., February 1, 2005; 174(3): 1532 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Betsuyaku, Y. Kuroki, K. Nagai, Y. Nasuhara, and M. Nishimura Effects of ageing and smoking on SP-A and SP-D levels in bronchoalveolar lavage fluid Eur. Respir. J., December 1, 2004; 24(6): 964 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Oberley, K. L. Goss, K. A. Ault, E. C. Crouch, and J. M. Snyder Surfactant protein D is present in the human female reproductive tract and inhibits Chlamydia trachomatis infection Mol. Hum. Reprod., December 1, 2004; 10(12): 861 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Dave, T. Childs, and J. A. Whitsett Nuclear Factor of Activated T Cells Regulates Transcription of the Surfactant Protein D Gene (Sftpd) via Direct Interaction with Thyroid Transcription Factor-1 in Lung Epithelial Cells J. Biol. Chem., August 13, 2004; 279(33): 34578 - 34588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Leth-Larsen, C. Floridon, O. Nielsen, and U. Holmskov Surfactant protein D in the female genital tract Mol. Hum. Reprod., March 1, 2004; 10(3): 149 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Hickling, H. Clark, R. Malhotra, and R. B. Sim Collectins and their role in lung immunity J. Leukoc. Biol., January 1, 2004; 75(1): 27 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Madsen, I. Tornoe, O. Nielsen, C. Koch, W. Steinhilber, and U. Holmskov Expression and Localization of Lung Surfactant Protein A in Human Tissues Am. J. Respir. Cell Mol. Biol., November 1, 2003; 29(5): 591 - 597. [Abstract] [Full Text]
|
|
|
|
|
|
J. Nadesalingam, A. L. Bernal, A. W. Dodds, A. C. Willis, D. J. Mahoney, A. J. Day, K. B. M. Reid, and N. Palaniyar Identification and Characterization of a Novel Interaction between Pulmonary Surfactant Protein D and Decorin J. Biol. Chem., July 3, 2003; 278(28): 25678 - 25687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wagner, N. J. Lynch, W. Walter, W. J. Schwaeble, and M. Loos Differential Expression of the Murine Mannose-Binding Lectins A and C in Lymphoid and Nonlymphoid Organs and Tissues J. Immunol., February 1, 2003; 170(3): 1462 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Uemura, M. Saka, T. Nakagawa, N. Kawasaki, S. Thiel, J. C. Jensenius, and T. Kawasaki L-MBP Is Expressed in Epithelial Cells of Mouse Small Intestine J. Immunol., December 15, 2002; 169(12): 6945 - 6950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Lin and J. Floros Heterogeneous allele expression of pulmonary SP-D gene in rat large intestine and other tissues Physiol Genomics, December 3, 2002; 11(3): 235 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hansen, D. Holm, V. Moeller, L. Vitved, C. Bendixen, K. B. M. Reid, K. Skjoedt, and U. Holmskov CL-46, a Novel Collectin Highly Expressed in Bovine Thymus and Liver J. Immunol., November 15, 2002; 169(10): 5726 - 5734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Hartshorn, M. R. White, and E. C. Crouch Contributions of the N- and C-Terminal Domains of Surfactant Protein D to the Binding, Aggregation, and Phagocytic Uptake of Bacteria Infect. Immun., November 1, 2002; 70(11): 6129 - 6139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hawgood, M. Ochs, A. Jung, J. Akiyama, L. Allen, C. Brown, J. Edmondson, S. Levitt, E. Carlson, A. M. Gillespie, et al. Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L1002 - L1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang, M. Ikegami, C. R. Dey, T. R. Korfhagen, and J. A. Whitsett Reversibility of Pulmonary Abnormalities by Conditional Replacement of Surfactant Protein D (SP-D) in Vivo J. Biol. Chem., October 4, 2002; 277(41): 38709 - 38713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Vandivier, C. A. Ogden, V. A. Fadok, P. R. Hoffmann, K. K. Brown, M. Botto, M. J. Walport, J. H. Fisher, P. M. Henson, and K. E. Greene Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex J. Immunol., October 1, 2002; 169(7): 3978 - 3986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Bisgaard, U. Holmskov, E. Santoni-Rugiu, P. Nagy, O. Nielsen, P. Ott, E. Hage, K. Dalhoff, L. J. Rasmussen, and N. Tygstrup Heterogeneity of Ductular Reactions in Adult Rat and Human Liver Revealed by Novel Expression of Deleted in Malignant Brain Tumor 1 Am. J. Pathol., October 1, 2002; 161(4): 1187 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sahly, I. Ofek, R. Podschun, H. Brade, Y. He, U. Ullmann, and E. Crouch Surfactant Protein D Binds Selectively to Klebsiella pneumoniae Lipopolysaccharides Containing Mannose-Rich O-Antigens J. Immunol., September 15, 2002; 169(6): 3267 - 3274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Hall, K. G. Hamil, and F. S. French Host Defense Proteins of the Male Reproductive Tract J Androl, September 1, 2002; 23(5): 585 - 597. [Full Text] [PDF]
|
|
|
|
|
|
J. Akiyama, A. Hoffman, C. Brown, L. Allen, J. Edmondson, F. Poulain, and S. Hawgood Tissue Distribution of Surfactant Proteins A and D in the Mouse J. Histochem. Cytochem., July 1, 2002; 50(7): 993 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Fisher, J. Larson, C. Cool, and S. W. Dow Lymphocyte Activation in the Lungs of SP-D Null Mice Am. J. Respir. Cell Mol. Biol., July 1, 2002; 27(1): 24 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Homer, T. Zheng, G. Chupp, S. He, Z. Zhu, Q. Chen, B. Ma, R. D. Hite, L. I. Gobran, S. A. Rooney, et al. Pulmonary type II cell hypertrophy and pulmonary lipoproteinosis are features of chronic IL-13 exposure Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L52 - L59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Augusto, J. Li, M. Synguelakis, J. Johansson, and R. Chaby Structural Basis for Interactions between Lung Surfactant Protein C and Bacterial Lipopolysaccharide J. Biol. Chem., June 21, 2002; 277(26): 23484 - 23492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. He and E. Crouch Surfactant Protein D Gene Regulation. INTERACTIONS AMONG THE CONSERVED CCAAT/ENHANCER-BINDING PROTEIN ELEMENTS J. Biol. Chem., May 24, 2002; 277(22): 19530 - 19537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Stahlman, M. E. Gray, W. M. Hull, and J. A. Whitsett Immunolocalization of Surfactant Protein-D (SP-D) in Human Fetal, Newborn, and Adult Tissues J. Histochem. Cytochem., May 1, 2002; 50(5): 651 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J Boyton and P. J Openshaw Pulmonary defences to acute respiratory infection Br. Med. Bull., March 1, 2002; 61(1): 1 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Murray, W. Khamri, M. M. Walker, P. Eggleton, A. P. Moran, J. A. Ferris, S. Knapp, Q. N. Karim, M. Worku, P. Strong, et al. Expression of Surfactant Protein D in the Human Gastric Mucosa and during Helicobacter pylori Infection Infect. Immun., March 1, 2002; 70(3): 1481 - 1487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Shepherd Pulmonary surfactant protein D: a novel link between innate and adaptive immunity Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L516 - L517. [Full Text] [PDF]
|
|
|
|
|
|
K. G. Brinker, E. Martin, P. Borron, E. Mostaghel, C. Doyle, C. V. Harding, and J. R. Wright Surfactant protein D enhances bacterial antigen presentation by bone marrow-derived dendritic cells Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1453 - L1463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Paananen, R. Sormunen, V. Glumoff, M. van Eijk, and M. Hallman Surfactant proteins A and D in Eustachian tube epithelium Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L660 - L667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. He, E. C. Crouch, K. Rust, E. Spaite, and S. L. Brody Proximal Promoter of the Surfactant Protein D Gene. REGULATORY ROLES OF AP-1, FORKHEAD BOX, AND GT BOX BINDING PROTEINS J. Biol. Chem., September 29, 2000; 275(40): 31051 - 31060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pan, L. D. Nielsen, M. J. Allen, K. M. Shannon, J. M. Shannon, M. Selman, and Robert. J. Mason Serum SP-D is a marker of lung injury in rats Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L824 - L832. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
