| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
GSF-National Research Center for Environment and Health, Institute of Experimental Hematology, München, Germany;
Institute of Immunology, Johannes Gutenberg University Mainz, Mainz, Germany; and
Division of Clinical Pharmacology, Medizinische Klinik, Klinikum Innenstadt of the Ludwig-Maximilians-University Munich, München, Germany
Mast cells can play detrimental roles in the pathophysiology and
mortality observed in anaphylaxis and other Th2-dominated allergic
diseases. In contrast, these cells contribute to protective host
defense mechanisms against parasitic worm infections. After IgE/Ag
activation, mast cells can produce multiple cytokines that may enhance
allergic inflammations, while a similar panel of Th2-related cytokines
may support immunological strategies against parasites. Here we report
that in primary mouse bone marrow-derived mast cells activated by
ionomycin or IgE/Ag, the proinflammatory mediator IL-1 (
or ß)
up-regulated production of IL-3, IL-5, IL-6, and IL-9 as well as TNF,
i.e., cytokines implicated in many inflammatory processes including
those associated with allergies and helminthic infections. IL-1 did not
induce significant cytokine release in the absence of ionomycin or
IgE/Ag, suggesting that Ca-dependent signaling was required.
IL-1-mediated enhancement of cytokine expression was confirmed at the
mRNA level by Northern blot and/or RT-PCR analysis. Our study reveals a
role for IL-1 in the up-regulation of multiple mast cell-derived
cytokines. Moreover, we identify mast cells as a novel source of IL-9.
These results are of particular importance in the light of recent
reports that strongly support a central role of IL-9 in allergic lung
inflammation and in host defense against worm
infections.
This article has been cited by other articles:
|
|
 |
|
  L. H. Ho, T. Ohno, K. Oboki, N. Kajiwara, H. Suto, M. Iikura, Y. Okayama, S. Akira, H. Saito, S. J. Galli, et al. IL-33 induces IL-13 production by mouse mast cells independently of IgE-Fc{epsilon}RI signals J. Leukoc. Biol., December 1, 2007; 82(6): 1481 - 1490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-Y. Yang, T.-H. Kuo, and L.-P. Ting Human Hepatitis B Viral e Antigen Interacts with Cellular Interleukin-1 Receptor Accessory Protein and Triggers Interleukin-1 Response J. Biol. Chem., November 10, 2006; 281(45): 34525 - 34536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Chen, G. Sen, and C. M. Snapper Endogenous IL-1R1 Signaling Is Critical for Cognate CD4+ T Cell Help for Induction of In Vivo Type 1 and Type 2 Antipolysaccharide and Antiprotein Ig Isotype Responses to Intact Streptococcus pneumoniae, but Not to a Soluble Pneumococcal Conjugate Vaccine J. Immunol., November 1, 2006; 177(9): 6044 - 6051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Monticelli, D. U. Lee, J. Nardone, D. L. Bolton, and A. Rao Chromatin-based regulation of cytokine transcription in Th2 cells and mast cells Int. Immunol., November 1, 2005; 17(11): 1513 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Lee, S. M. Fitzgerald, S. K. Huang, C. Li, D. S. Chi, D. M. Milhorn, and G. Krishnaswamy Molecular Regulation of Interleukin-13 and Monocyte Chemoattractant Protein-1 Expression in Human Mast Cells by Interleukin-1{beta} Am. J. Respir. Cell Mol. Biol., September 1, 2004; 31(3): 283 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kandere-Grzybowska, R. Letourneau, D. Kempuraj, J. Donelan, S. Poplawski, W. Boucher, A. Athanassiou, and T. C. Theoharides IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells J. Immunol., November 1, 2003; 171(9): 4830 - 4836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nakae, Y. Komiyama, H. Yokoyama, A. Nambu, M. Umeda, M. Iwase, I. Homma, K. Sudo, R. Horai, M. Asano, et al. IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response Int. Immunol., April 1, 2003; 15(4): 483 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Stassen, C. Muller, M. Arnold, L. Hultner, S. Klein-Hessling, C. Neudorfl, T. Reineke, E. Serfling, and E. Schmitt IL-9 and IL-13 Production by Activated Mast Cells Is Strongly Enhanced in the Presence of Lipopolysaccharide: NF-{{kappa}}B Is Decisively Involved in the Expression of IL-9 J. Immunol., April 1, 2001; 166(7): 4391 - 4398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Biedermann, M. Kneilling, R. Mailhammer, K. Maier, C. A. Sander, G. Kollias, S. L. Kunkel, L. Hultner, and M. Rocken Mast Cells Control Neutrophil Recruitment during T Cell-mediated Delayed-type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2 J. Exp. Med., November 13, 2000; 192(10): 1441 - 1452. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
