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CUTTING EDGE |
*
Immunogenetics Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;
Department of Immunology, The Babraham Institute, Cambridge, United Kingdom;
Arthritis Clinical Research Unit, Virginia Mason Research Center, Seattle, WA 98101; and
§
Division of Rheumatology, University of Washington, Seattle, WA 98195
The host’s MHC genotype plays a critical role in susceptibility
to autoimmune diseases. We previously proposed that persistent fetal
microchimerism from pregnancy contributes to the pathogenesis of
autoimmune diseases such as scleroderma. In the current study, we
investigated whether the specific host MHC genotype is associated with
persistent microchimerism among T lymphocytes in women with scleroderma
and in healthy women. Fetal microchimerism among T lymphocytes was
strongly associated with HLA DQA1*0501 of the mother (odds ratio
(OR) = 13.5, p = 0.007, p
corrected (pc) = 0.06) and even more strongly with
DQA1*0501 of the son (OR = 
; p = 0.00002,
pc = 0.0002). This is the first description of an
association between persistent fetal microchimerism in maternal T
lymphocytes and specific HLA class II alleles. Although the association
was observed in both healthy women and in women with scleroderma, the
finding suggests an additional route by which HLA genes might
contribute to susceptibility to autoimmune
disease.
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