| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109
Macrophage-derived chemokine (MDC), a recently identified CC
chemokine, has been regarded to be involved in chronic inflammation and
dendritic cell and lymphocyte homing. In this study, we demonstrate a
pivotal role for MDC during experimental sepsis induced by cecal
ligation and puncture (CLP). Intraperitoneal administration of MDC (1
µg/mouse) protected mice from CLP-induced lethality. The survival was
accompanied by increased number of peritoneal macrophages and decreased
recovery of viable bacteria from the peritoneum and peripheral blood.
In addition, mice treated with an i.p. injection of MDC cleared
bacteria more effectively than those in the control when 3 x
108 CFU live Escherichia coli was i.p.
inoculated. Endogenous MDC was detected in the peritoneum after CLP,
and neutralization of the MDC with anti-MDC Abs decreased
CLP-induced recruitment of peritoneal macrophages and increased the
recovery of viable bacteria from the peritoneum and peripheral blood.
MDC blockade was deleterious in the survival of mice after CLP. In
vitro, MDC enhanced the phagocytic and killing activities of peritoneal
macrophages to E. coli and induced both a respiratory
burst and the release of lysozomal enzyme from macrophages.
Furthermore, MDC dramatically ameliorated CLP-induced systemic tissue
inflammation as well as tissue dysfunction, which were associated in
part with decreased levels of TNF-
, macrophage inflammatory
proteins-1 and -2, and KC in specific tissues. Collectively, these
results indicate novel regulatory activities of MDC in innate immunity
during sepsis and suggest that MDC may aid in an adjunct therapy in
sepsis.
This article has been cited by other articles:
|
|
 |
|
  Y. Ishida, T. Hayashi, T. Goto, A. Kimura, S. Akimoto, N. Mukaida, and T. Kondo Essential Involvement of CX3CR1-Mediated Signals in the Bactericidal Host Defense during Septic Peritonitis J. Immunol., September 15, 2008; 181(6): 4208 - 4218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Watanabe, M. Kubo, K. Numata, K. Takagi, H. Mizuta, S. Okada, T. Ito, and A. Matsukawa Overexpression of Suppressor of Cytokine Signaling-5 in T Cells Augments Innate Immunity during Septic Peritonitis J. Immunol., December 15, 2006; 177(12): 8650 - 8657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Dey, A. Sarkar, N. Majumder, S. Bhattacharyya (Majumdar), K. Roychoudhury, S. Bhattacharyya, S. Roy, and S. Majumdar Regulation of Impaired Protein Kinase C Signaling by Chemokines in Murine Macrophages during Visceral Leishmaniasis Infect. Immun., December 1, 2005; 73(12): 8334 - 8344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Carpenter, K. F. Buckland, Z. Xing, and C. M. Hogaboam Intrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis Infect. Immun., December 1, 2005; 73(12): 8402 - 8406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Carpenter and C. M. Hogaboam Immunosuppressive Effects of CCL17 on Pulmonary Antifungal Responses during Pulmonary Invasive Aspergillosis Infect. Immun., November 1, 2005; 73(11): 7198 - 7207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Matsukawa, S. Kudo, T. Maeda, K. Numata, H. Watanabe, K. Takeda, S. Akira, and T. Ito Stat3 in Resident Macrophages as a Repressor Protein of Inflammatory Response J. Immunol., September 1, 2005; 175(5): 3354 - 3359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ghadially, X.-L. Ross, C. Kerst, J. Dong, A. B. Reske-Kunz, and R. Ross Differential Regulation of CCL22 Gene Expression in Murine Dendritic Cells and B Cells J. Immunol., May 1, 2005; 174(9): 5620 - 5629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fu, O. L. C. Wijburg, P. U. Cameron, J. D. Price, and R. A Strugnell Salmonella enterica Serovar Typhimurium Infection of Dendritic Cells Leads to Functionally Increased Expression of the Macrophage-Derived Chemokine Infect. Immun., March 1, 2005; 73(3): 1714 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Ness, K. J. Carpenter, J. L. Ewing, C. J. Gerard, C. M. Hogaboam, and S. L. Kunkel CCR1 and CC Chemokine Ligand 5 Interactions Exacerbate Innate Immune Responses during Sepsis J. Immunol., December 1, 2004; 173(11): 6938 - 6948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Shi, K. Takahashi, J. Dundee, S. Shahroor-Karni, S. Thiel, J. C. Jensenius, F. Gad, M. R. Hamblin, K. N. Sastry, and R. A. B. Ezekowitz Mannose-binding Lectin-deficient Mice Are Susceptible to Infection with Staphylococcus aureus J. Exp. Med., May 17, 2004; 199(10): 1379 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wang, A. Satoskar, W. Faubion, D. Howie, S. Okamoto, S. Feske, C. Gullo, K. Clarke, M. R. Sosa, A. H. Sharpe, et al. The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions J. Exp. Med., May 3, 2004; 199(9): 1255 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Chazaud, C. Sonnet, P. Lafuste, G. Bassez, A.-C. Rimaniol, F. Poron, F.-J. Authier, P. A. Dreyfus, and R. K. Gherardi Satellite cells attract monocytes and use macrophages as a support to escape apoptosis and enhance muscle growth J. Cell Biol., December 8, 2003; 163(5): 1133 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Matsukawa, K. Takeda, S. Kudo, T. Maeda, M. Kagayama, and S. Akira Aberrant Inflammation and Lethality to Septic Peritonitis in Mice Lacking STAT3 in Macrophages and Neutrophils J. Immunol., December 1, 2003; 171(11): 6198 - 6205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Ness, C. M. Hogaboam, R. M. Strieter, and S. L. Kunkel Immunomodulatory Role of CXCR2 During Experimental Septic Peritonitis J. Immunol., October 1, 2003; 171(7): 3775 - 3784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Pinho, S. H. Oliveira, D. G. Souza, D. Vasconcelos, A. L. Alessandri, N. W. Lukacs, and M. M. Teixeira The role of CCL22 (MDC) for the recruitment of eosinophils during allergic pleurisy in mice J. Leukoc. Biol., March 1, 2003; 73(3): 356 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takahashi, T. Tashiro, M. Miyazaki, M. Kobayashi, R. B. Pollard, and F. Suzuki An essential role of macrophage inflammatory protein 1{alpha}/CCL3 on the expression of host's innate immunities against infectious complications J. Leukoc. Biol., December 1, 2002; 72(6): 1190 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Chensue Molecular Machinations: Chemokine Signals in Host-Pathogen Interactions Clin. Microbiol. Rev., October 1, 2001; 14(4): 821 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Berin, M. B. Dwinell, L. Eckmann, and M. F. Kagnoff Production of MDC/CCL22 by human intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, June 1, 2001; 280(6): G1217 - G1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Matsukawa, M. H. Kaplan, C. M. Hogaboam, N. W. Lukacs, and S. L. Kunkel Pivotal Role of Signal Transducer and Activator of Transcription (Stat)4 and Stat6 in the Innate Immune Response during Sepsis J. Exp. Med., March 19, 2001; 193(6): 679 - 688. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
