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ra Michalová1Max Planck Institut für Biologie, Abteilung Immungenetik, Tübingen, Germany
In contrast to the human and mouse Mhc, in which the
clusters of class I and class II loci reside in close vicinity to one
another, in the zebrafish, Danio rerio, they are found
in different linkage groups. Chromosome walking using BAC (bacterial
artificial chromosome) and PAC (P1 artificial chromosome) clones
reveals the zebrafish class I region to occupy a segment of 
450 kb
and to encompass at least 19 loci. These include three class I
(Dare-UDA, -UEA, -UFA), five proteasome subunit ß
(PSMB8, -9A, -9C, -11, -12), two TAPs (TAP2A,
TAP2B), and one TAP binding protein (TAPBP).
This arrangement contrasts with the arrangements found in human and
mouse Mhc, in which the orthologues of the PSMB,
TAP, and TAPBP loci reside within the class II
region. In addition to this main zebrafish class I contig, a shorter
contig of about 150 kb contains two additional class I (UBA,
UCA) and at least five other loci. It probably represents a
different haplotype of part of the class I region. The previously
identified UAA gene shares an identical 5' part with
UEA, but the two genes differ in their 3' parts. One of
them is probably the result of an unequal crossing over. The described
organization has implications for the persistence of syntenic
relationships, coevolution of loci, and interpretation of the origin of
the human/mouse Mhc organization.
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