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Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA
The thymus has been regarded as the major site of T cell
differentiation. We find that in addition to 
ß and 
T cells,
a significant number (
3 x 104 per day) of
B220+IgM+ mature B cells are exported from the
thymus of C57BL/6 mice. Of these emigrating B cells, we estimate that
at least 2 x 104 per day are cells which developed
intrathymically, whereas a maximum of 0.8 x 104
per day are cells which circulated through the thymus from the
periphery. The thymus possesses a significant number of pro-B and pre-B
cells that express CD19, VpreB, 
5, and pax-5. These B cell
progenitors were found in the thymic cortex, whereas increasingly
mature B cells were found in the corticomedullar and medullary regions.
Other lymphoid cells, including NK cells and lymphoid dendritic cells,
are not exported from the thymus at detectable levels. Thus, the thymus
contributes to the formation of peripheral pools of B cells as well as
of ß and T cells.
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