| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
*
Institut für Anthropologie und Humangenetik, Munich, Germany;
Mouse Immunogenetics, Institut National de la Santé et de la Recherche Médicale Unité 462, Institute of Hematology, Saint-Louis Hospital, Paris, France;
Max von Pettenkofer-Institut, Ludwig-Maximilians-Universität München, Munich, Germany; and
§
Institut für Experimentelle Hämatologie, GSF-Forschungszentrum, Munich, Germany
Human CMV has evolved multiple strategies to interfere with immune recognition of the host. A variety of mechanisms target Ag presentation by MHC class I molecules resulting in a reduced class I cell-surface expression. This down-regulation of class I molecules is expected to trigger NK cytotoxicity, which would have to be counteracted by the virus to establish long-term infection. Here we describe that the human CMV open reading frame UL40 encodes a canonical ligand for HLA-E, identical with the HLA-Cw03 signal sequence-derived peptide. Expression of UL40 in HLA-E-positive target cells conferred resistance to NK cell lysis via the CD94/NKG2A receptor. Generation of the UL40-derived HLA-E ligand was also observed in TAP-deficient cells. The presence of a functional TAP-independent HLA-E ligand in the UL40 signal sequence implicates this viral gene as an important negative regulator of NK activity.
This article has been cited by other articles:
|
|
 |
|
  E. Lo Monaco, L. Sibilio, E. Melucci, E. Tremante, M. Suchanek, V. Horejsi, A. Martayan, and P. Giacomini HLA-E: Strong Association with {beta}2-Microglobulin and Surface Expression in the Absence of HLA Class I Signal Sequence-Derived Peptides J. Immunol., October 15, 2008; 181(8): 5442 - 5450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Achdout, I. Manaster, and O. Mandelboim Influenza Virus Infection Augments NK Cell Inhibition through Reorganization of Major Histocompatibility Complex Class I Proteins J. Virol., August 15, 2008; 82(16): 8030 - 8037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Swanson II, C. D. Pack, A. Hadley, C.-R. Wang, I. Stroynowski, P. E. Jensen, and A. E. Lukacher An MHC class Ib-restricted CD8 T cell response confers antiviral immunity J. Exp. Med., July 7, 2008; 205(7): 1647 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Kaiser, J. C. Pizarro, J. Kerns, and R. K. Strong Structural basis for NKG2A/CD94 recognition of HLA-E PNAS, May 6, 2008; 105(18): 6696 - 6701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Petrie, C. S. Clements, J. Lin, L. C. Sullivan, D. Johnson, T. Huyton, A. Heroux, H. L. Hoare, T. Beddoe, H. H. Reid, et al. CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence J. Exp. Med., March 17, 2008; 205(3): 725 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Xie, A. Dighe, P. Clark, P. Sabastian, S. Buss, and M. G. Brown Deficient Major Histocompatibility Complex-Linked Innate Murine Cytomegalovirus Immunity in MA/My.L-H2b Mice and Viral Downregulation of H-2k Class I Proteins J. Virol., January 1, 2007; 81(1): 229 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Nattermann, G Feldmann, G Ahlenstiel, B Langhans, T Sauerbruch, and U Spengler Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C Gut, June 1, 2006; 55(6): 869 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Guma, M. Budt, A. Saez, T. Brckalo, H. Hengel, A. Angulo, and M. Lopez-Botet Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts Blood, May 1, 2006; 107(9): 3624 - 3631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Mavoungou Interactions between natural killer cells, cortisol and prolactin in malaria during pregnancy. Clin. Med. Res., March 1, 2006; 4(1): 33 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Iannello, O. Debbeche, E. Martin, L. H. Attalah, S. Samarani, and A. Ahmad Viral strategies for evading antiviral cellular immune responses of the host J. Leukoc. Biol., January 1, 2006; 79(1): 16 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Barel, N. Pizzato, P. Le Bouteiller, E. J. H. J. Wiertz, and F. Lenfant Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation Int. Immunol., January 1, 2006; 18(1): 173 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. T. Pande, C. Powers, K. Ahn, and K. Fruh Rhesus Cytomegalovirus Contains Functional Homologues of US2, US3, US6, and US11 J. Virol., May 1, 2005; 79(9): 5786 - 5798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nattermann, H. D. Nischalke, V. Hofmeister, G. Ahlenstiel, H. Zimmermann, L. Leifeld, E. H. Weiss, T. Sauerbruch, and U. Spengler The HLA-A2 Restricted T Cell Epitope HCV Core35-44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells Am. J. Pathol., February 1, 2005; 166(2): 443 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guma, A. Angulo, C. Vilches, N. Gomez-Lozano, N. Malats, and M. Lopez-Botet Imprint of human cytomegalovirus infection on the NK cell receptor repertoire Blood, December 1, 2004; 104(12): 3664 - 3671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jinushi, T. Takehara, T. Tatsumi, T. Kanto, T. Miyagi, T. Suzuki, Y. Kanazawa, N. Hiramatsu, and N. Hayashi Negative Regulation of NK Cell Activities by Inhibitory Receptor CD94/NKG2A Leads to Altered NK Cell-Induced Modulation of Dendritic Cell Functions in Chronic Hepatitis C Virus Infection J. Immunol., November 15, 2004; 173(10): 6072 - 6081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. L. W. Chang, N. Baumgarth, D. Yu, and P. A. Barry Human Cytomegalovirus-Encoded Interleukin-10 Homolog Inhibits Maturation of Dendritic Cells and Alters Their Functionality J. Virol., August 15, 2004; 78(16): 8720 - 8731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Pietra, C. Romagnani, P. Mazzarino, M. Falco, E. Millo, A. Moretta, L. Moretta, and M. C. Mingari HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes PNAS, September 16, 2003; 100(19): 10896 - 10901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Miller, D. A. Weber, C. Ibegbu, J. Pohl, J. D. Altman, and P. E. Jensen Analysis of HLA-E Peptide-Binding Specificity and Contact Residues in Bound Peptide Required for Recognition by CD94/NKG2 J. Immunol., August 1, 2003; 171(3): 1369 - 1375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Odeberg, H. Browne, S. Metkar, C. J. Froelich, L. Branden, D. Cosman, and C. Soderberg-Naucler The Human Cytomegalovirus Protein UL16 Mediates Increased Resistance to Natural Killer Cell Cytotoxicity through Resistance to Cytolytic Proteins J. Virol., April 15, 2003; 77(8): 4539 - 4545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Falk, M. Mach, D. J. Schendel, E. H. Weiss, I. Hilgert, and G. Hahn NK Cell Activity During Human Cytomegalovirus Infection Is Dominated by US2-11-Mediated HLA Class I Down-Regulation J. Immunol., September 15, 2002; 169(6): 3257 - 3266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Y. Wang, B. McSharry, C. Retiere, P. Tomasec, S. Williams, L. K. Borysiewicz, V. M. Braud, and G. W. G. Wilkinson From the Cover: UL40-mediated NK evasion during productive infection with human cytomegalovirus PNAS, May 28, 2002; 99(11): 7570 - 7575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Lemberg, F. A. Bland, A. Weihofen, V. M. Braud, and B. Martoglio Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes J. Immunol., December 1, 2001; 167(11): 6441 - 6446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Kavanagh, M. C. Gold, M. Wagner, U. H. Koszinowski, and A. B. Hill The Multiple Immune-evasion Genes of Murine Cytomegalovirus Are Not Redundant: m4 and m152 Inhibit Antigen Presentation In a Complementary and Cooperative Fashion J. Exp. Med., October 1, 2001; 194(7): 967 - 978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Riteau, C. Menier, I. Khalil-Daher, S. Martinozzi, M. Pla, J. Dausset, E. D. Carosella, and N. Rouas-Freiss HLA-G1 co-expression boosts the HLA class I-mediated NK lysis inhibition Int. Immunol., February 1, 2001; 13(2): 193 - 201. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
