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CUTTING EDGE |
Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75235
Stromal cell-derived factor (SDF)-1 is a chemoattractant for T
cells, precursor B cells, monocytes, and neutrophils. SDF-1
was also
found to up-regulate expression of early activation markers (CD69,
CD25, and CD154) by anti-CD3-activated CD4+ T cells. In
addition, SDF-1 costimulated proliferation of CD4+ T
cells and production of IL-2, IFN-
, IL-4, and IL-10. Stimulation
with SDF-1 alone did not induce activation marker expression,
proliferation, or cytokine production by the CD4+ T cells.
SDF-1-mediated costimulation was blocked by anti-CXC chemokine
receptor-4 mAb. RANTES also increased activation marker expression by
anti-CD3-stimulated peripheral CD4+ T cells, but less
effectively than SDF-1 did, and did not up-regulate IL-2 production
and proliferation. These results indicate that SDF-1 and CXC chemokine
receptor-4 interactions not only play a role in T cell migration but
also provide potent costimulatory signals to Ag-stimulated T
cells.
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Y. Suzuki, M. Rahman, and H. Mitsuya Diverse Transcriptional Response of CD4+ T Cells to Stromal Cell-Derived Factor (SDF)-1: Cell Survival Promotion and Priming Effects of SDF-1 on CD4+ T Cells J. Immunol., September 15, 2001; 167(6): 3064 - 3073. [Abstract] [Full Text] [PDF]
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N. C. Ottoson, J. T. Pribila, A. S. H. Chan, and Y. Shimizu Cutting Edge: T Cell Migration Regulated by CXCR4 Chemokine Receptor Signaling to ZAP-70 Tyrosine Kinase J. Immunol., August 15, 2001; 167(4): 1857 - 1861. [Abstract] [Full Text] [PDF]
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 R. S. Klein, J. B. Rubin, H. D. Gibson, E. N. DeHaan, X. Alvarez-Hernandez, R. A. Segal, and A. D. Luster SDF-1{alpha} induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells Development, June 1, 2001; 128(11): 1971 - 1981. [Abstract] [Full Text] [PDF]
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 D. Dubois-Laforgue, H. Hendel, S. Caillat-Zucman, J.-F. Zagury, C. Winkler, C. Boitard, and J. Timsit A Common Stromal Cell-Derived Factor-1 Chemokine Gene Variant is Associated With the Early Onset of Type 1 Diabetes Diabetes, May 1, 2001; 50(5): 1211 - 1213. [Abstract] [Full Text]
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J.-W. Oh, K. Drabik, O. Kutsch, C. Choi, A. Tousson, and E. N. Benveniste CXC Chemokine Receptor 4 Expression and Function in Human Astroglioma Cells J. Immunol., February 15, 2001; 166(4): 2695 - 2704. [Abstract] [Full Text] [PDF]
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T. Nanki, K. Hayashida, H. S. El-Gabalawy, S. Suson, K. Shi, H. J. Girschick, S. Yavuz, and P. E. Lipsky Stromal Cell-Derived Factor-1-CXC Chemokine Receptor 4 Interactions Play a Central Role in CD4+ T Cell Accumulation in Rheumatoid Arthritis Synovium J. Immunol., December 1, 2000; 165(11): 6590 - 6598. [Abstract] [Full Text] [PDF]
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