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The Journal of Immunology, 2000, 164: 5000-5004.
Copyright © 2000 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice1

Defu Zeng, Mi-Kyeong Lee, James Tung, Andrea Brendolan and Samuel Strober2

Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94306

Since anti-CD1 TCR transgenic T cells can activate syngeneic B cells via CD1 to secrete IgM and IgG and induce lupus in BALB/c mice, we studied the role of CD1 in the pathogenesis of lupus in NZB/NZW mice. Approximately 20% of B cells from the spleens of NZB/NZW mice expressed high levels of CD1 (CD1high B cells). The latter subset spontaneously produced large amounts of IgM anti-dsDNA Abs in vitro that was up to 25-fold higher than that of residual CD1int/low B cells. T cells in the NZB/NZW spleen proliferated vigorously to the CD1-transfected A20 B cell line, but not to the parent line. Treatment of NZB/NZW mice with anti-CD1 mAbs ameliorated the development of lupus. These results suggest that the CD1high B cells and their progeny are a major source of autoantibody production, and activation of B cells via CD1 may play an important role in the pathogenesis of lupus.




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