| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Departments of Medicine and Microbiology-Immunology, University of California, San Francisco, CA 94143
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) from platelets and macrophages mediate T cell functions. Endothelial differentiation gene-encoded G protein-coupled receptors (Edg Rs) are specific for S1P (Edg-1, -3, -5, and -8 Rs) and LPA (Edg-2, -4, and -7 Rs). Human T cell tumors express many Edg Rs for both LPA and S1P. In contrast, human blood CD4+ T cells express predominantly Edg-4, and CD8+ T cells show only traces of Edg-2 and -5, by quantification of mRNA and Edg R Ags. LPA at 10-10–10-6 M suppressed significantly the secretion of IL-2 from anti-CD3 plus anti-CD28 Ab-challenged CD4+ T cells, but not CD8+ T cells. Monoclonal anti-Edg-4 R Ab, like LPA, suppressed stimulated IL-2 secretion from CD4+ T cells, but not CD8+ T cells. Constitutive expression of Edg-4 by CD4+, but not CD8+, human T cells accounts for differential functional responsiveness of the T cell subsets to LPA.
This article has been cited by other articles:
|
|
 |
|
  M. Dottori, J. Leung, A. M. Turnley, and A. Pebay Lysophosphatidic Acid Inhibits Neuronal Differentiation of Neural Stem/Progenitor Cells Derived from Human Embryonic Stem Cells Stem Cells, May 1, 2008; 26(5): 1146 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kotarsky, A. Boketoft, J. Bristulf, N. E. Nilsson, A. Norberg, S. Hansson, C. Owman, R. Sillard, L. M. F. Leeb-Lundberg, and B. Olde Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes J. Pharmacol. Exp. Ther., August 1, 2006; 318(2): 619 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rubenfeld, J. Guo, N. Sookrung, R. Chen, W. Chaicumpa, V. Casolaro, Y. Zhao, V. Natarajan, and S. Georas Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cells Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L66 - L74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Lin and J. A. Boyce IL-4 Regulates MEK Expression Required for Lysophosphatidic Acid-Mediated Chemokine Generation by Human Mast Cells J. Immunol., October 15, 2005; 175(8): 5430 - 5438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pebay, R. C.B. Wong, S. M. Pitson, E. J. Wolvetang, G. S.-L. Peh, A. Filipczyk, K. L.L. Koh, I. Tellis, L. T.V. Nguyen, and M. F. Pera Essential Roles of Sphingosine-1-Phosphate and Platelet-Derived Growth Factor in the Maintenance of Human Embryonic Stem Cells Stem Cells, October 1, 2005; 23(10): 1541 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bagga, K. S. Price, D. A. Lin, D. S. Friend, K. F. Austen, and J. A. Boyce Lysophosphatidic acid accelerates the development of human mast cells Blood, December 15, 2004; 104(13): 4080 - 4087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Goetzl and M. H. Graler Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T Lymphocytes J. Leukoc. Biol., July 1, 2004; 76(1): 30 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kimura, A. M. Boehmler, G. Seitz, S. Kuci, T. Wiesner, V. Brinkmann, L. Kanz, and R. Mohle The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells Blood, June 15, 2004; 103(12): 4478 - 4486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Gobeil Jr., S. G. Bernier, A. Vazquez-Tello, S. Brault, M. H. Beauchamp, C. Quiniou, A. M. Marrache, D. Checchin, F. Sennlaub, X. Hou, et al. Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1 J. Biol. Chem., October 3, 2003; 278(40): 38875 - 38883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Graeler, Y. Kong, J. S. Karliner, and E. J. Goetzl Protein Kinase C {epsilon} Dependence of the Recovery from Down-regulation of S1P1 G Protein-coupled Receptors of T Lymphocytes J. Biol. Chem., July 18, 2003; 278(30): 27737 - 27741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jin, E. Knudsen, L. Wang, Y. Bryceson, B. Damaj, S. Gessani, and A. A. Maghazachi Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation Blood, June 15, 2003; 101(12): 4909 - 4915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Drobnik, G. Liebisch, F.-X. Audebert, D. Frohlich, T. Gluck, P. Vogel, G. Rothe, and G. Schmitz Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients J. Lipid Res., April 1, 2003; 44(4): 754 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. GRAELER and E. J. GOETZL Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells FASEB J, December 1, 2002; 16(14): 1874 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-A. Wang, H. Du, J. H. Jaggar, D. N. Brindley, G. J. Tigyi, and M. A. Watsky Injury-elicited differential transcriptional regulation of phospholipid growth factor receptors in the cornea Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1646 - C1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Graeler, G. Shankar, and E. J. Goetzl Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate J. Immunol., October 15, 2002; 169(8): 4084 - 4087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fischer, D. Chatterjee, J. Torrelles, P. J. Brennan, S. H. E. Kaufmann, and U. E. Schaible Mycobacterial Lysocardiolipin Is Exported from Phagosomes upon Cleavage of Cardiolipin by a Macrophage-Derived Lysosomal Phospholipase A2 J. Immunol., August 15, 2001; 167(4): 2187 - 2192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zheng, Y. Kong, and E. J. Goetzl Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrane J. Immunol., February 15, 2001; 166(4): 2317 - 2322. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
