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CUTTING EDGE |
Basel Institute for Immunology, Basel, Switzerland
We have identified new activating receptors of the Ig
superfamily expressed on human myeloid cells, called TREM (triggering
receptor expressed on myeloid cells). TREM-1 is selectively expressed
on blood neutrophils and a subset of monocytes and is up-regulated by
bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8,
monocyte chemotactic protein-1, and TNF-
and induces neutrophil
degranulation. Intracellularly, TREM-1 induces Ca2+
mobilization and tyrosine phosphorylation of
extracellular signal-related kinase 1 (ERK1), ERK2 and
phospholipase C-
. To mediate activation, TREM-1 associates with the
transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation
of neutrophil and monocytes, and may have a predominant role in
inflammatory responses.
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J. R. Bleharski, V. Kiessler, C. Buonsanti, P. A. Sieling, S. Stenger, M. Colonna, and R. L. Modlin A Role for Triggering Receptor Expressed on Myeloid Cells-1 in Host Defense During the Early-Induced and Adaptive Phases of the Immune Response J. Immunol., April 1, 2003; 170(7): 3812 - 3818. [Abstract] [Full Text] [PDF]
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A. V. Washington, L. Quigley, and D. W. McVicar Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster Blood, November 15, 2002; 100(10): 3822 - 3824. [Abstract] [Full Text] [PDF]
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G. W. Henkel, S. R. McKercher, and R. A. Maki Identification of three genes up-regulated in PU.1 rescued monocytic precursor cells Int. Immunol., July 1, 2002; 14(7): 723 - 732. [Abstract] [Full Text] [PDF]
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D. Mason, P. Andre, A. Bensussan, C. Buckley, C. Civin, E. Clark, M. de Haas, S. Goyert, M. Hadam, D. Hart, et al. CD antigens 2002 Blood, May 15, 2002; 99(10): 3877 - 3880. [Full Text] [PDF]
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D. Mason, P. Andre, A. Bensussan, C. Buckley, C. Civin, E. Clark, M. de Haas, S. Goyert, M. Hadam, D. Hart, et al. CD antigens 2001 J. Leukoc. Biol., November 1, 2001; 70(5): 685 - 690. [Abstract] [Full Text] [PDF]
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A. Bouchon, C. Hernandez-Munain, M. Cella, and M. Colonna A Dap12-Mediated Pathway Regulates Expression of Cc Chemokine Receptor 7 and Maturation of Human Dendritic Cells J. Exp. Med., October 15, 2001; 194(8): 1111 - 1122. [Abstract] [Full Text] [PDF]
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N. Aoki, S. Kimura, Y. Takiyama, Y. Atsuta, A. Abe, K. Sato, and M. Katagiri The Role of the DAP12 Signal in Mouse Myeloid Differentiation J. Immunol., October 1, 2000; 165(7): 3790 - 3796. [Abstract] [Full Text] [PDF]
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