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CUTTING EDGE |
Basel Institute for Immunology, Basel, Switzerland
We have identified new activating receptors of the Ig
superfamily expressed on human myeloid cells, called TREM (triggering
receptor expressed on myeloid cells). TREM-1 is selectively expressed
on blood neutrophils and a subset of monocytes and is up-regulated by
bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8,
monocyte chemotactic protein-1, and TNF-
and induces neutrophil
degranulation. Intracellularly, TREM-1 induces Ca2+
mobilization and tyrosine phosphorylation of
extracellular signal-related kinase 1 (ERK1), ERK2 and
phospholipase C-
. To mediate activation, TREM-1 associates with the
transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation
of neutrophil and monocytes, and may have a predominant role in
inflammatory responses.
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A. Bouchon, C. Hernandez-Munain, M. Cella, and M. Colonna A Dap12-Mediated Pathway Regulates Expression of Cc Chemokine Receptor 7 and Maturation of Human Dendritic Cells J. Exp. Med., October 15, 2001; 194(8): 1111 - 1122. [Abstract] [Full Text] [PDF] |
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N. Aoki, S. Kimura, Y. Takiyama, Y. Atsuta, A. Abe, K. Sato, and M. Katagiri The Role of the DAP12 Signal in Mouse Myeloid Differentiation J. Immunol., October 1, 2000; 165(7): 3790 - 3796. [Abstract] [Full Text] [PDF] |
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