The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fukao, T.
Right arrow Articles by Koyasu, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fukao, T.
Right arrow Articles by Koyasu, S.
The Journal of Immunology, 2000, 164: 64-71.
Copyright © 2000 by The American Association of Immunologists

Synergistic Effects of IL-4 and IL-18 on IL-12-Dependent IFN-{gamma} Production by Dendritic Cells1

Taro Fukao, Satoshi Matsuda and Shigeo Koyasu2

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan

Mouse splenic dendritic cells (DCs) produce IFN-{gamma} in response to IL-12. In the present study, we analyzed effects of Th1 and Th2 cytokines on IFN-{gamma} production by DCs. IL-18 produced by DCs and macrophages acts in an autocrine manner and augments IL-12-induced IFN-{gamma} production by DCs as also observed in T and NK cells. Surprisingly, IL-4, a Th2 cytokine, also acts synergistically with IL-12 on IFN-{gamma} production by DCs. In addition, IL-4 markedly enhances IFN-{gamma} production when DCs are stimulated through CD40 or MHC class II. These results indicate that both Th1 and Th2 cytokines act on DCs during T cell-DC interaction upon Ag presentation. p38 mitogen-activated protein kinase is constitutively activated in mature DCs and is required for IFN-{gamma} production by DCs. IL-18 but not IL-4 or IL-12 further activates the p38 mitogen-activated protein kinase activity, suggesting that IL-4 and IL-18 enhance IFN-{gamma} production through distinct intracellular signal transduction pathways in DCs.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. M. Moretto, L. M. Weiss, C. L. Combe, and I. A. Khan
IFN-{gamma}-Producing Dendritic Cells Are Important for Priming of Gut Intraepithelial Lymphocyte Response Against Intracellular Parasitic Infection
J. Immunol., August 15, 2007; 179(4): 2485 - 2492.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Tomizawa, Y. Kaneko, Y. Kaneko, Y. Saito, H. Ohnishi, J. Okajo, C. Okuzawa, T. Ishikawa-Sekigami, Y. Murata, H. Okazawa, et al.
Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T Cell Priming by Dendritic Cells in Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Mutant Mice
J. Immunol., July 15, 2007; 179(2): 869 - 877.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Salagianni, W. K. Loon, M. J. Thomas, A. Noble, and D. M. Kemeny
An Essential Role for IL-18 in CD8 T Cell-Mediated Suppression of IgE Responses
J. Immunol., April 15, 2007; 178(8): 4771 - 4778.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
K. Obayashi, T. Doi, and S. Koyasu
Dendritic cells suppress IgE production in B cells
Int. Immunol., February 1, 2007; 19(2): 217 - 226.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
U. I. Chaudhry, T. P. Kingham, G. Plitas, S. C. Katz, J. R. Raab, and R. P. DeMatteo
Combined Stimulation with Interleukin-18 and CpG Induces Murine Natural Killer Dendritic Cells to Produce IFN-{gamma} and Inhibit Tumor Growth
Cancer Res., November 1, 2006; 66(21): 10497 - 10504.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Li, W. Wojciechowski, C. Dell'Agnola, N. E. Lopez, and I. Espinoza-Delgado
IFN-{gamma} and T-bet Expression in Human Dendritic Cells from Normal Donors and Cancer Patients Is Controlled through Mechanisms Involving ERK-1/2-Dependent and IL-12-Independent Pathways
J. Immunol., September 15, 2006; 177(6): 3554 - 3563.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
H. Ito, E. Esashi, T. Akiyama, J.-i. Inoue, and A. Miyajima
IL-18 produced by thymic epithelial cells induces development of dendritic cells with CD11b in the fetal thymus
Int. Immunol., August 1, 2006; 18(8): 1253 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
U. I. Chaudhry, S. C. Katz, T. P. Kingham, V. G. Pillarisetty, J. R. Raab, A. B. Shah, and R. P. DeMatteo
In vivo overexpression of Flt3 ligand expands and activates murine spleen natural killer dendritic cells
FASEB J, May 1, 2006; 20(7): 982 - 984.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Fricke, D. Mitchell, J. Mittelstadt, N. Lehan, H. Heine, T. Goldmann, A. Bohle, and S. Brandau
Mycobacteria Induce IFN-{gamma} Production in Human Dendritic Cells via Triggering of TLR2
J. Immunol., May 1, 2006; 176(9): 5173 - 5182.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Iinuma, K. Okinaga, R. Fukushima, T. Inaba, K. Iwasaki, A. Okinaga, I. Takahashi, and M. Kaneko
Superior Protective and Therapeutic Effects of IL-12 and IL-18 Gene-Transduced Dendritic Neuroblastoma Fusion Cells on Liver Metastasis of Murine Neuroblastoma
J. Immunol., March 15, 2006; 176(6): 3461 - 3469.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Otsu, K. Gotoh, T. Yamashiro, J. Yamagata, K. Shin, T. Fujioka, and A. Nishizono
Transfer of Antigen-Pulsed Dendritic Cells Induces Specific T-Cell Proliferation and a Therapeutic Effect against Long-Term Helicobacter pylori Infection in Mice
Infect. Immun., February 1, 2006; 74(2): 984 - 993.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Suto, H. Nakajima, N. Tokumasa, H. Takatori, S.-i. Kagami, K. Suzuki, and I. Iwamoto
Murine Plasmacytoid Dendritic Cells Produce IFN-{gamma} upon IL-4 Stimulation
J. Immunol., November 1, 2005; 175(9): 5681 - 5689.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
Y. Sasaki, T. Yoshimoto, H. Maruyama, T. Tegoshi, N. Ohta, N. Arizono, and K. Nakanishi
IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity
J. Exp. Med., September 6, 2005; 202(5): 607 - 616.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
S. Tanaka, M. Sato, T. Onitsuka, H. Kamata, and Y. Yokomizo
Inflammatory Cytokine Gene Expression in Different Types of Granulomatous Lesions during Asymptomatic Stages of Bovine Paratuberculosis
Vet. Pathol., September 1, 2005; 42(5): 579 - 588.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. S. Bezbradica, A. K. Stanic, N. Matsuki, H. Bour-Jordan, J. A. Bluestone, J. W. Thomas, D. Unutmaz, L. Van Kaer, and S. Joyce
Distinct Roles of Dendritic Cells and B Cells in Va14Ja18 Natural T Cell Activation In Vivo
J. Immunol., April 15, 2005; 174(8): 4696 - 4705.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. H. Yun, A. Lundgren, J. Azem, A. Sjoling, J. Holmgren, A.-M. Svennerholm, and B. S. Lundin
Natural Killer Cells and Helicobacter pylori Infection: Bacterial Antigens and Interleukin-12 Act Synergistically To Induce Gamma Interferon Production
Infect. Immun., March 1, 2005; 73(3): 1482 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. G. Pillarisetty, S. C. Katz, J. I. Bleier, A. B. Shah, and R. P. DeMatteo
Natural Killer Dendritic Cells Have Both Antigen Presenting and Lytic Function and in Response to CpG Produce IFN-{gamma} via Autocrine IL-12
J. Immunol., March 1, 2005; 174(5): 2612 - 2618.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. A. Lyakh, M. Sanford, S. Chekol, H. A. Young, and A. B. Roberts
TGF-{beta} and Vitamin D3 Utilize Distinct Pathways to Suppress IL-12 Production and Modulate Rapid Differentiation of Human Monocytes into CD83+ Dendritic Cells
J. Immunol., February 15, 2005; 174(4): 2061 - 2070.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
U. Schleicher, A. Hesse, and C. Bogdan
Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-{gamma} in IL-12/IL-18-stimulated mouse macrophage populations
Blood, February 1, 2005; 105(3): 1319 - 1328.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Mavropoulos, G. Sully, A. P. Cope, and A. R. Clark
Stabilization of IFN-{gamma} mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells
Blood, January 1, 2005; 105(1): 282 - 288.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. L. Leisewitz, K. A. Rockett, B. Gumede, M. Jones, B. Urban, and D. P. Kwiatkowski
Response of the Splenic Dendritic Cell Population to Malaria Infection
Infect. Immun., July 1, 2004; 72(7): 4233 - 4239.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. G. Rothfuchs, M. R. Kreuger, H. Wigzell, and M. E. Rottenberg
Macrophages, CD4+ or CD8+ Cells Are Each Sufficient for Protection against Chlamydia pneumoniae Infection through their Ability to Secrete IFN-{gamma}
J. Immunol., February 15, 2004; 172(4): 2407 - 2415.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
N. M. Tsuji, H. Tsutsui, E. Seki, K. Kuida, H. Okamura, K. Nakanishi, and R. A. Flavell
Roles of caspase-1 in Listeria infection in mice
Int. Immunol., February 1, 2004; 16(2): 335 - 343.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume
Interferon-{gamma}: an overview of signals, mechanisms and functions
J. Leukoc. Biol., February 1, 2004; 75(2): 163 - 189.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P.-H. Chiang, L. Wang, C. A. Bonham, X. Liang, J. J. Fung, L. Lu, and S. Qian
Mechanistic Insights into Impaired Dendritic Cell Function by Rapamycin: Inhibition of Jak2/Stat4 Signaling Pathway
J. Immunol., February 1, 2004; 172(3): 1355 - 1363.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. Blackstock and J. W. Murphy
Role of Interleukin-4 in Resistance to Cryptococcus neoformans Infection
Am. J. Respir. Cell Mol. Biol., January 1, 2004; 30(1): 109 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Tatsumi, J. Huang, W. E. Gooding, A. Gambotto, P. D. Robbins, N. L. Vujanovic, S. M. Alber, S. C. Watkins, H. Okada, and W. J. Storkus
Intratumoral Delivery of Dendritic Cells Engineered to Secrete Both Interleukin (IL)-12 and IL-18 Effectively Treats Local and Distant Disease in Association with Broadly Reactive Tc1-type Immunity
Cancer Res., October 1, 2003; 63(19): 6378 - 6386.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Jefford, M. Schnurr, T. Toy, K.-A. Masterman, A. Shin, T. Beecroft, T. Y. Tai, K. Shortman, M. Shackleton, I. D. Davis, et al.
Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli
Blood, September 1, 2003; 102(5): 1753 - 1763.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
M. M. Gherardi, J. C. Ramirez, and M. Esteban
IL-12 and IL-18 act in synergy to clear vaccinia virus infection: involvement of innate and adaptive components of the immune system
J. Gen. Virol., August 1, 2003; 84(8): 1961 - 1972.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. H. Bream, R. E. Curiel, C.-R. Yu, C. E. Egwuagu, M. J. Grusby, T. M. Aune, and H. A. Young
IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-{gamma} expression in murine NK cells
Blood, July 1, 2003; 102(1): 207 - 214.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Lugo-Villarino, R. Maldonado-Lopez, R. Possemato, C. Penaranda, and L. H. Glimcher
T-bet is required for optimal production of IFN-{gamma} and antigen-specific T cell activation by dendritic cells
PNAS, June 24, 2003; 100(13): 7749 - 7754.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Ito, A. Matejuk, C. Hopke, H. Drought, J. Dwyer, A. Zamora, S. Subramanian, A. A. Vandenbark, and H. Offner
Transfer of Severe Experimental Autoimmune Encephalomyelitis by IL-12- and IL-18-Potentiated T Cells Is Estrogen Sensitive
J. Immunol., May 1, 2003; 170(9): 4802 - 4809.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
T. Yoshimoto, B. Min, T. Sugimoto, N. Hayashi, Y. Ishikawa, Y. Sasaki, H. Hata, K. Takeda, K. Okumura, L. Van Kaer, et al.
Nonredundant Roles for CD1d-restricted Natural Killer T Cells and Conventional CD4+ T Cells in the Induction of Immunoglobulin E Antibodies in Response to Interleukin 18 Treatment of Mice
J. Exp. Med., April 21, 2003; 197(8): 997 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. A. Gracie, S. E. Robertson, and I. B. McInnes
Interleukin-18
J. Leukoc. Biol., February 1, 2003; 73(2): 213 - 224.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. Sashinami, A. Nakane, Y. Iwakura, and M. Sasaki
Effective Induction of Acquired Resistance to Listeria monocytogenes by Immunizing Mice with In Vivo-Infected Dendritic Cells
Infect. Immun., January 1, 2003; 71(1): 117 - 125.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Al-Darmaki, H. A. Schenkein, J. G. Tew, and S. E. Barbour
Differential Expression of Platelet-Activating Factor Acetylhydrolase in Macrophages and Monocyte-Derived Dendritic Cells
J. Immunol., January 1, 2003; 170(1): 167 - 173.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Kitaura, N. Nagata, Y. Fujimura, H. Hotokezaka, N. Yoshida, and K. Nakayama
Effect of IL-12 on TNF-{alpha}-Mediated Osteoclast Formation in Bone Marrow Cells: Apoptosis Mediated by Fas/Fas Ligand Interaction
J. Immunol., November 1, 2002; 169(9): 4732 - 4738.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Seki, H. Tsutsui, N. M. Tsuji, N. Hayashi, K. Adachi, H. Nakano, S. Futatsugi-Yumikura, O. Takeuchi, K. Hoshino, S. Akira, et al.
Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of Listeria monocytogenes in Mice
J. Immunol., October 1, 2002; 169(7): 3863 - 3868.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Shirasugi, A. B. Adams, M. M. Durham, A. E. Lukacher, H. Xu, P. Rees, S. R. Cowan, M. A. Williams, T. C. Pearson, and C. P. Larsen
Prevention of Chronic Rejection in Murine Cardiac Allografts: A Comparison of Chimerism- and Nonchimerism-Inducing Costimulation Blockade-Based Tolerance Induction Regimens
J. Immunol., September 1, 2002; 169(5): 2677 - 2684.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. E. Barbour, Y. Ishihara, M. Fakher, S. Al-Darmaki, T. H. Caven, C. P. Shelburne, A. M. Best, H. A. Schenkein, and J. G. Tew
Monocyte Differentiation in Localized Juvenile Periodontitis Is Skewed toward the Dendritic Cell Phenotype
Infect. Immun., June 1, 2002; 70(6): 2780 - 2786.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Maldonado-Lopez, C. Maliszewski, J. Urbain, and M. Moser
Cytokines Regulate the Capacity of CD8{alpha}+ and CD8{alpha}- Dendritic Cells to Prime Th1/Th2 Cells In Vivo
J. Immunol., October 15, 2001; 167(8): 4345 - 4350.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Puig-Kroger, M. Relloso, O. Fernandez-Capetillo, A. Zubiaga, A. Silva, C. Bernabeu, and A. L. Corbi
Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells
Blood, October 1, 2001; 98(7): 2175 - 2182.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. E. Morelli, A. F. Zahorchak, A. T. Larregina, B. L. Colvin, A. J. Logar, T. Takayama, L. D. Falo, and A. W. Thomson
Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation
Blood, September 1, 2001; 98(5): 1512 - 1523.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Trobonjaca, F. Leithauser, P. Moller, R. Schirmbeck, and J. Reimann
Activating Immunity in the Liver. I. Liver Dendritic Cells (but Not Hepatocytes) Are Potent Activators of IFN-{gamma} Release by Liver NKT Cells
J. Immunol., August 1, 2001; 167(3): 1413 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Stober, R. Schirmbeck, and J. Reimann
IL-12/IL-18-Dependent IFN-{{gamma}} Release by Murine Dendritic Cells
J. Immunol., July 15, 2001; 167(2): 957 - 965.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. Kang and Y. Suzuki
Requirement of Non-T Cells That Produce Gamma Interferon for Prevention of Reactivation of Toxoplasma gondii Infection in the Brain
Infect. Immun., May 1, 2001; 69(5): 2920 - 2927.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Hochrein, K. Shortman, D. Vremec, B. Scott, P. Hertzog, and M. O'Keeffe
Differential Production of IL-12, IFN-{{alpha}}, and IFN-{{gamma}} by Mouse Dendritic Cell Subsets
J. Immunol., May 1, 2001; 166(9): 5448 - 5455.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. J. Horwood, J. Elliott, T. J. Martin, and M. T. Gillespie
IL-12 Alone and in Synergy with IL-18 Inhibits Osteoclast Formation In Vitro
J. Immunol., April 15, 2001; 166(8): 4915 - 4921.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Fukao, D. M. Frucht, G. Yap, M. Gadina, J. J. O'Shea, and S. Koyasu
Inducible Expression of Stat4 in Dendritic Cells and Macrophages and Its Critical Role in Innate and Adaptive Immune Responses
J. Immunol., April 1, 2001; 166(7): 4446 - 4455.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. M. Fort, R. Lesley, N. J. Davidson, S. Menon, F. Brombacher, M. W. Leach, and D. M. Rennick
IL-4 Exacerbates Disease in a Th1 Cell Transfer Model of Colitis
J. Immunol., February 15, 2001; 166(4): 2793 - 2800.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
G. Cai, R. Kastelein, and C. A. Hunter
Interleukin-18 (IL-18) Enhances Innate IL-12-Mediated Resistance to Toxoplasma gondii
Infect. Immun., December 1, 2000; 68(12): 6932 - 6938.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. Fantuzzi, P. Puddu, B. Varano, M. Del Cornò, F. Belardelli, and S. Gessani
IFN-{alpha} and IL-18 exert opposite regulatory effects on the IL-12 receptor expression and IL-12-induced IFN-{gamma} production in mouse macrophages: novel pathways in the regulation of the inflammatory response of macrophages
J. Leukoc. Biol., November 1, 2000; 68(5): 707 - 714.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
A. Puig-Kroger, F. Sanz-Rodriguez, N. Longo, P. Sanchez-Mateos, L. Botella, J. Teixido, C. Bernabeu, and A. L. Corbi
Maturation-Dependent Expression and Function of the CD49d Integrin on Monocyte-Derived Human Dendritic Cells
J. Immunol., October 15, 2000; 165(8): 4338 - 4345.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
H. Hochrein, M. O'Keeffe, T. Luft, S. Vandenabeele, R. J. Grumont, E. Maraskovsky, and K. Shortman
Interleukin (IL)-4 Is a Major Regulatory Cytokine Governing Bioactive IL-12 Production by Mouse and Human Dendritic Cells
J. Exp. Med., September 11, 2000; 192(6): 823 - 834.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Kalinski, H. H. Smits, J. H. N. Schuitemaker, P. L. Vieira, M. van Eijk, E. C. de Jong, E. A. Wierenga, and M. L. Kapsenberg
IL-4 Is a Mediator of IL-12p70 Induction by Human Th2 Cells: Reversal of Polarized Th2 Phenotype by Dendritic Cells
J. Immunol., August 15, 2000; 165(4): 1877 - 1881.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Nagayama, K. Sato, H. Kawasaki, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, S. Asano, and T. A. Takahashi
IL-12 Responsiveness and Expression of IL-12 Receptor in Human Peripheral Blood Monocyte-Derived Dendritic Cells
J. Immunol., July 1, 2000; 165(1): 59 - 66.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. U. Bagriacik and J. R. Klein
The Thyrotropin (Thyroid-Stimulating Hormone) Receptor Is Expressed on Murine Dendritic Cells and on a Subset of CD45RBhigh Lymph Node T Cells: Functional Role for Thyroid-Stimulating Hormone During Immune Activation
J. Immunol., June 15, 2000; 164(12): 6158 - 6165.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.