| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Epimmune, San Diego, CA 92121;
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715
Since the onset of the HIV pandemic, the use of nonhuman primate models of infection has increasingly become important. An excellent model to study HIV infection and immunological responses, in particular cell-mediated immune responses, is SIV infection of rhesus macaques. CTL epitopes have been mapped using SIV-infected rhesus macaques, but, to date, a peptide binding motif has been described for only one rhesus class I MHC molecule, Mamu-A*01. Herein, we have established peptide-live cell binding assays for four rhesus MHC class I molecules: Mamu-A*11, -B*03, -B*04, and -B*17. Using such assays, peptide binding motifs have been established for all four of these rhesus MHC class I molecules. With respect to the nature and spacing of crucial anchor positions, the motifs defined for Mamu-B*04 and -B*17 present unique features not previously observed for other primate species. The motifs identified for Mamu-A*11 and -B*03 are very similar to the peptide binding motifs previously described for human HLA-B*44 and -B*27, respectively. Accordingly, naturally processed peptides derived from HLA-B*44 and HLA-B*27 specifically bind Mamu-A*11 and Mamu-B*03, respectively, indicating that conserved MHC class I binding capabilities exist between rhesus macaques and humans. The definition of four rhesus MHC class I-specific motifs expands our ability to accurately detect and quantitate immune responses to MHC class I-restricted epitopes in rhesus macaques and to rationally design peptide epitope-based model vaccine constructs destined for use in nonhuman primates.
This article has been cited by other articles:
|
|
 |
|
  J. T. Loffredo, J. Sidney, A. T. Bean, D. R. Beal, W. Bardet, A. Wahl, O. E. Hawkins, S. Piaskowski, N. A. Wilson, W. H. Hildebrand, et al. Two MHC Class I Molecules Associated with Elite Control of Immunodeficiency Virus Replication, Mamu-B*08 and HLA-B*2705, Bind Peptides with Sequence Similarity J. Immunol., June 15, 2009; 182(12): 7763 - 7775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Kalli, C. J. Krco, L. C. Hartmann, K. Goodman, M. J. Maurer, C. Yu, E. M. Johnson, C. L. Erskine, M. L. Disis, P. J. Wettstein, et al. An HLA-DR-Degenerate Epitope Pool Detects Insulin-like Growth Factor Binding Protein 2-Specific Immunity in Patients with Cancer Cancer Res., June 15, 2008; 68(12): 4893 - 4901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Loffredo, J. Maxwell, Y. Qi, C. E. Glidden, G. J. Borchardt, T. Soma, A. T. Bean, D. R. Beal, N. A. Wilson, W. M. Rehrauer, et al. Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication J. Virol., August 15, 2007; 81(16): 8827 - 8832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Chu, Z. Lou, Y. W. Chen, Y. Liu, B. Gao, L. Zong, A. H. Khan, J. I. Bell, Z. Rao, and G. F. Gao First Glimpse of the Peptide Presentation by Rhesus Macaque MHC Class I: Crystal Structures of Mamu-A*01 Complexed with Two Immunogenic SIV Epitopes and Insights into CTL Escape J. Immunol., January 15, 2007; 178(2): 944 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. Hickman-Miller, W. Bardet, A. Gilb, A. D. Luis, K. W. Jackson, D. I. Watkins, and W. H. Hildebrand Rhesus Macaque MHC Class I Molecules Present HLA-B-Like Peptides J. Immunol., July 1, 2005; 175(1): 367 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Tscharke, G. Karupiah, J. Zhou, T. Palmore, K. R. Irvine, S.M. M. Haeryfar, S. Williams, J. Sidney, A. Sette, J. R. Bennink, et al. Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines J. Exp. Med., January 3, 2005; 201(1): 95 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Daza-Vamenta, G. Glusman, L. Rowen, B. Guthrie, and D. E. Geraghty Genetic Divergence of the Rhesus Macaque Major Histocompatibility Complex Genome Res., August 1, 2004; 14(8): 1501 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sidney, S. Southwood, V. Pasquetto, and A. Sette Simultaneous Prediction of Binding Capacity for Multiple Molecules of the HLA B44 Supertype J. Immunol., December 1, 2003; 171(11): 5964 - 5974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. McGuire, S. R. Leib, R. H. Mealey, D. G. Fraser, and D. J. Prieur Presentation and Binding Affinity of Equine Infectious Anemia Virus CTL Envelope and Matrix Protein Epitopes by an Expressed Equine Classical MHC Class I Molecule J. Immunol., August 15, 2003; 171(4): 1984 - 1993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. P. Lafont, A. Buckler-White, R. Plishka, C. Buckler, and M. A. Martin Characterization of Pig-Tailed Macaque Classical MHC Class I Genes: Implications for MHC Evolution and Antigen Presentation in Macaques J. Immunol., July 15, 2003; 171(2): 875 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sidney, M.-F. del Guercio, S. Southwood, and A. Sette The HLA Molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 Share an Extensive Overlap in Peptide Binding Specificity J. Immunol., November 1, 2002; 169(9): 5098 - 5108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. U. Vogel, T. C. Friedrich, D. H. O'Connor, W. Rehrauer, E. J. Dodds, H. Hickman, W. Hildebrand, J. Sidney, A. Sette, A. Hughes, et al. Escape in One of Two Cytotoxic T-Lymphocyte Epitopes Bound by a High-Frequency Major Histocompatibility Complex Class I Molecule, Mamu-A*02: a Paradigm for Virus Evolution and Persistence? J. Virol., October 11, 2002; 76(22): 11623 - 11636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Mothe, J. Sidney, J. L. Dzuris, M. E. Liebl, S. Fuenger, D. I. Watkins, and A. Sette Characterization of the Peptide-Binding Specificity of Mamu-B*17 and Identification of Mamu-B*17-Restricted Epitopes Derived from Simian Immunodeficiency Virus Proteins J. Immunol., July 1, 2002; 169(1): 210 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Dzuris, J. Sidney, H. Horton, R. Correa, D. Carter, R. W. Chesnut, D. I. Watkins, and A. Sette Molecular Determinants of Peptide Binding to Two Common Rhesus Macaque Major Histocompatibility Complex Class II Molecules J. Virol., November 15, 2001; 75(22): 10958 - 10968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Allen, B. R. Mothé, J. Sidney, P. Jing, J. L. Dzuris, M. E. Liebl, T. U. Vogel, D. H. O'Connor, X. Wang, M. C. Wussow, et al. CD8+ Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing J. Virol., January 15, 2001; 75(2): 738 - 749. [Abstract] [Full Text]
|
|
|
|
|
|
J. Sidney, J. L. Dzuris, M. J. Newman, R. P. Johnson, K. Amitinder, C. M. Walker, E. Appella, B. Mothe, D. I. Watkins, and A. Sette Definition of the Mamu A*01 Peptide Binding Specificity: Application to the Identification of Wild-Type and Optimized Ligands from Simian Immunodeficiency Virus Regulatory Proteins J. Immunol., December 1, 2000; 165(11): 6387 - 6399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Evans, P. Jing, T. M. Allen, D. H. O'Connor, H. Horton, J. E. Venham, M. Piekarczyk, J. Dzuris, M. Dykhuzen, J. Mitchen, et al. Definition of Five New Simian Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitopes and Their Restricting Major Histocompatibility Complex Class I Molecules: Evidence for an Influence on Disease Progression J. Virol., August 15, 2000; 74(16): 7400 - 7410. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
