| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Division of Immunology and Transplantation Biology, Department of Pediatrics, and
Department of Pathology, Stanford University, Stanford, CA 94305
Asthma is a respiratory disorder characterized by airway
hyperreactivity (AHR) and inflammation and is associated with high
serum IgE and overproduction of IL-4, IL-5, and IL-13 by
allergen-specific Th2 cells. Our previous studies demonstrated that
heat-killed Listeria monocytogenes (HKL) as an adjuvant
in immunotherapy successfully reversed ongoing Ag-specific
Th2-dominated responses toward Th1-dominated responses, but it was
unclear if such immune modulation could reverse ongoing, established
disease in target organs such as the lung. In this paper we show that a
single dose of Ag plus HKL as adjuvant significantly reduced AHR in a
murine model for asthma and reversed established AHR when given late
after allergen sensitization. HKL as adjuvant also dramatically
inhibited airway inflammation, eosinophilia, and mucus production,
significantly reduced Ag-specific IgE and IL-4 production, and
dramatically increased Ag-specific IFN-
synthesis. The inhibitory
effect of HKL on AHR depended on the presence of IL-12 and
CD8+ T cells and was associated with an increase of IL-18
mRNA expression. Thus, our results demonstrate that HKL as an adjuvant
for immunotherapy mediates immune deviation from a pathological
Th2-dominated response toward a protective immune response in
peripheral lymphoid tissues and in the lungs and may be clinically
effective in the treatment of patients with established asthma and
allergic disease.
This article has been cited by other articles:
|
|
 |
|
  M. Maret, C. Ruffie, S. Letuve, A. Phelep, O. Thibaudeau, J. Marchal, M. Pretolani, and A. Druilhe A Role for Bid in Eosinophil Apoptosis and in Allergic Airway Reaction J. Immunol., May 1, 2009; 182(9): 5740 - 5747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Maret, C. Ruffie, B. Periquet, A.-M. Campo, M. Menevret, A. Phelep, K. Dziewiszek, A. Druilhe, and M. Pretolani Liposomal Retinoic Acids Modulate Asthma Manifestations in Mice J. Nutr., December 1, 2007; 137(12): 2730 - 2736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Salagianni, W. K. Loon, M. J. Thomas, A. Noble, and D. M. Kemeny An Essential Role for IL-18 in CD8 T Cell-Mediated Suppression of IgE Responses J. Immunol., April 15, 2007; 178(8): 4771 - 4778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Korf, G. Pynaert, K. Tournoy, T. Boonefaes, A. Van Oosterhout, D. Ginneberge, A. Haegeman, J. A. Verschoor, P. De Baetselier, and J. Grooten Macrophage Reprogramming by Mycolic Acid Promotes a Tolerogenic Response in Experimental Asthma Am. J. Respir. Crit. Care Med., July 15, 2006; 174(2): 152 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. M. van Oosterhout and N. Bloksma Regulatory T-lymphocytes in asthma Eur. Respir. J., November 1, 2005; 26(5): 918 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. M. van Oosterhout and A. C. Motta Th1/Th2 paradigm: not seeing the forest for the trees? Eur. Respir. J., April 1, 2005; 25(4): 591 - 593. [Full Text] [PDF]
|
|
|
|
 |
|
 J.-K. Peng, J.-S. Lin, J. T. Kung, F. D. Finkelman, and B. A. Wu-Hsieh The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection Int. Immunol., February 1, 2005; 17(2): 193 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kuipers, C. Heirman, D. Hijdra, F. Muskens, M. Willart, S. van Meirvenne, K. Thielemans, H. C. Hoogsteden, and B. N. Lambrecht Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization J. Leukoc. Biol., November 1, 2004; 76(5): 1028 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Smart, P. S. Foster, M. E. Rothenberg, T. J. V. Higgins, and S. P. Hogan A Plant-Based Allergy Vaccine Suppresses Experimental Asthma Via an IFN-{gamma} and CD4+CD45RBlow T Cell-Dependent Mechanism J. Immunol., August 15, 2003; 171(4): 2116 - 2126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wohlleben, J. Muller, U. Tatsch, C. Hambrecht, U. Herz, H. Renz, E. Schmitt, H. Moll, and K. J. Erb Influenza A Virus Infection Inhibits the Efficient Recruitment of Th2 Cells into the Airways and the Development of Airway Eosinophilia J. Immunol., May 1, 2003; 170(9): 4601 - 4611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-M. Li, K. Srivastava, J. W. Huleatt, K. Bottomly, A. W. Burks, and H. A. Sampson Engineered Recombinant Peanut Protein and Heat-Killed Listeria monocytogenes Coadministration Protects Against Peanut-Induced Anaphylaxis in a Murine Model J. Immunol., March 15, 2003; 170(6): 3289 - 3295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Walter, J. J. McIntire, G. Berry, A. N. J. McKenzie, D. D. Donaldson, R. H. DeKruyff, and D. T. Umetsu Critical Role for IL-13 in the Development of Allergen-Induced Airway Hyperreactivity J. Immunol., October 15, 2001; 167(8): 4668 - 4675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Walter, C. P. Wong, R. H. DeKruyff, G. J. Berry, S. Levy, and D. T. Umetsu IL-18 Gene Transfer by Adenovirus Prevents the Development of and Reverses Established Allergen-Induced Airway Hyperreactivity J. Immunol., May 15, 2001; 166(10): 6392 - 6398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mizuki, T. Miura, S. Sasaki, M. Mizuki, H. Madarame, and A. Nakane Interference between Host Resistance to Listeria monocytogenes Infection and Ovalbumin-Induced Allergic Responses in Mice Infect. Immun., March 1, 2001; 69(3): 1883 - 1888. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
