| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
B/Rel Signaling in the Type 1 But Not Type 2 T Cell-Dependent Immune Response In Vivo1
,
Divisions of
*
Allergy, Pulmonary, and Critical Care Medicine and
Rheumatology, Department of Medicine,
Department of Microbiology and Immunology, and
§
Department of Pathology, Vanderbilt University Medical School, Nashville, TN 37232; and
¶
Pulmonary Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115.
T cell function is a critical determinant of immune responses as
well as susceptibility to allergic diseases. Activated T cells can
differentiate into effectors whose cytokine profile is limited to type
1 (IFN-
-dominant) or type 2 (IL-4-, IL-5-dominant) patterns. To
investigate mechanisms that connect extracellular stimuli with the
regulation of effector T cell function, we have measured immune
responses of transgenic mice whose NF-
B/Rel signaling pathway is
inhibited in T cells. Surprisingly, these mice developed type 2 T
cell-dependent responses (IgE and eosinophil recruitment) in a model of
allergic pulmonary inflammation. In contrast, type 1 T cell responses
were severely impaired, as evidenced by markedly diminished
delayed-type hypersensitivity responses, IFN- production, and
Ag-specific IgG2a levels. Taken together, these data indicate that
inhibition of NF-B can lead to preferential impairment of type 1 as
compared with type 2 T cell-dependent responses.
This article has been cited by other articles:
|
|
 |
|
  S. Mise-Omata, E. Kuroda, T. Sugiura, U. Yamashita, Y. Obata, and T. S. Doi The NF-{kappa}B RelA Subunit Confers Resistance to Leishmania major by Inducing Nitric Oxide Synthase 2 and Fas Expression but Not Th1 Differentiation J. Immunol., April 15, 2009; 182(8): 4910 - 4916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Song, T. So, and M. Croft Activation of NF-{kappa}B1 by OX40 Contributes to Antigen-Driven T Cell Expansion and Survival J. Immunol., June 1, 2008; 180(11): 7240 - 7248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ghosh, A. J. Janocha, M. A. Aronica, S. Swaidani, S. A. A. Comhair, W. Xu, L. Zheng, S. Kaveti, M. Kinter, S. L. Hazen, et al. Nitrotyrosine Proteome Survey in Asthma Identifies Oxidative Mechanism of Catalase Inactivation J. Immunol., May 1, 2006; 176(9): 5587 - 5597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Cheng, Y.-H. Liao, J. Zhang, B. Li, H. Ge, J. Yuan, M. Wang, B. Lu, Y. Liu, and Y. Cheng Effects of Atorvastatin on Th polarization in patients with acute myocardial infarction Eur J Heart Fail, December 1, 2005; 7(7): 1099 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Corn, C. Hunter, H.-C. Liou, U. Siebenlist, and M. R. Boothby Opposing Roles for RelB and Bcl-3 in Regulation of T-Box Expressed in T Cells, GATA-3, and Th Effector Differentiation J. Immunol., August 15, 2005; 175(4): 2102 - 2110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Silva, L. V. C. Guillermo, F. L. Ribeiro-Gomes, J. De Meis, R. M. S. Pereira, Z. Wu, T. C. Calegari-Silva, S. H. Seabra, U. G. Lopes, R. M. Siegel, et al. Caspase-8 Activity Prevents Type 2 Cytokine Responses and Is Required for Protective T Cell-Mediated Immunity against Trypanosoma cruzi Infection J. Immunol., May 15, 2005; 174(10): 6314 - 6321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Kumar, C. Herbert, D. C. Webb, L. Li, and P. S. Foster Effects of Anticytokine Therapy in a Mouse Model of Chronic Asthma Am. J. Respir. Crit. Care Med., November 15, 2004; 170(10): 1043 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Stanic, J. S. Bezbradica, J.-J. Park, L. Van Kaer, M. R. Boothby, and S. Joyce Cutting Edge: The Ontogeny and Function of Va14Ja18 Natural T Lymphocytes Require Signal Processing by Protein Kinase C{theta} and NF-{kappa}B J. Immunol., April 15, 2004; 172(8): 4667 - 4671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wu, L. Rinaldi, K. A. Fortner, J. Q. Russell, J. Tschopp, C. Irvin, and R. C. Budd Cellular FLIP Long Form-Transgenic Mice Manifest a Th2 Cytokine Bias and Enhanced Allergic Airway Inflammation J. Immunol., April 15, 2004; 172(8): 4724 - 4732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. McCracken, E. Gallery, and J. M. Morris Pregnancy-Specific Down-Regulation of NF-{kappa}B Expression in T Cells in Humans Is Essential for the Maintenance of the Cytokine Profile Required for Pregnancy Success J. Immunol., April 1, 2004; 172(7): 4583 - 4591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Aronica, S. McCarthy, S. Swaidani, D. Mitchell, M. Goral, J. R. Sheller, and M. Boothby Recall Helper T Cell Response: T Helper 1 Cell-resistant Allergic Susceptibility without Biasing Uncommitted CD4 T Cells Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 587 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Stanic, J. S. Bezbradica, J.-J. Park, N. Matsuki, A. L. Mora, L. Van Kaer, M. R. Boothby, and S. Joyce NF-{kappa}B Controls Cell Fate Specification, Survival, and Molecular Differentiation of Immunoregulatory Natural T Lymphocytes J. Immunol., February 15, 2004; 172(4): 2265 - 2273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hakamada-Taguchi, Y. Uehara, K. Kuribayashi, A. Numabe, K. Saito, H. Negoro, T. Fujita, T. Toyo-oka, and T. Kato Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development Circ. Res., November 14, 2003; 93(10): 948 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Corn, M. A. Aronica, F. Zhang, Y. Tong, S. A. Stanley, S. R. A. Kim, L. Stephenson, B. Enerson, S. McCarthy, A. Mora, et al. T Cell-Intrinsic Requirement for NF-{kappa}B Induction in Postdifferentiation IFN-{gamma} Production and Clonal Expansion in a Th1 Response J. Immunol., August 15, 2003; 171(4): 1816 - 1824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Mora, L. M. Stephenson, B. Enerson, J. Youn, A. D. Keegan, and M. Boothby New Programming of IL-4 Receptor Signal Transduction in Activated T Cells: Stat6 Induction and Th2 Differentiation Mediated by IL-4R{alpha} Lacking Cytoplasmic Tyrosines J. Immunol., August 15, 2003; 171(4): 1891 - 1900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Tato, A. Villarino, J. H. Caamano, M. Boothby, and C. A. Hunter Inhibition of NF-{kappa}B Activity in T and NK Cells Results in Defective Effector Cell Expansion and Production of IFN-{gamma} Required for Resistance to Toxoplasma gondii J. Immunol., March 15, 2003; 170(6): 3139 - 3146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dunne and L. A. J. O'Neill The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense Sci. Signal., February 25, 2003; 2003(171): re3 - re3. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Brint, K. A. Fitzgerald, P. Smith, A. J. Coyle, J.-C. Gutierrez-Ramos, P. G. Fallon, and L. A. J. O'Neill Characterization of Signaling Pathways Activated by the Interleukin 1 (IL-1) Receptor Homologue T1/ST2. A ROLE FOR JUN N-TERMINAL KINASE IN IL-4 INDUCTION J. Biol. Chem., December 13, 2002; 277(51): 49205 - 49211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Caamano and C. A. Hunter NF-{kappa}B Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions Clin. Microbiol. Rev., July 1, 2002; 15(3): 414 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Speirs, J. Caamano, M. H. Goldschmidt, C. A. Hunter, and P. Scott NF-{kappa}B2 Is Required for Optimal CD40-Induced IL-12 Production but Dispensable for Th1 Cell Differentiation J. Immunol., May 1, 2002; 168(9): 4406 - 4413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Loewe, W. Holnthoner, M. Groger, M. Pillinger, F. Gruber, D. Mechtcheriakova, E. Hofer, K. Wolff, and P. Petzelbauer Dimethylfumarate Inhibits TNF-Induced Nuclear Entry of NF-{kappa}B/p65 in Human Endothelial Cells J. Immunol., May 1, 2002; 168(9): 4781 - 4787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Wagner Jr., G. Vaitaitis, R. Sanderson, M. Poulin, C. Dobbs, and K. Haskins Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes PNAS, March 19, 2002; 99(6): 3782 - 3787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Haley, A. Ciota, J. P. Contreras, M. R. Boothby, D. L. Perkins, and P. W. Finn Alterations in lung collectins in an adaptive allergic immune response Am J Physiol Lung Cell Mol Physiol, March 1, 2002; 282(3): L573 - L584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Robles, E. Leonardo, L. M. Criado, M. Izquierdo, and C. Martinez-A. Inhibitor of Apoptosis Protein from Orgyia pseudotsugata Nuclear Polyhedrosis Virus Provides a Costimulatory Signal Required for Optimal Proliferation of Developing Thymocytes J. Immunol., February 15, 2002; 168(4): 1770 - 1779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Finn, J. R. Stone, M. R. Boothby, and D. L. Perkins Inhibition of NF-{kappa}B-Dependent T Cell Activation Abrogates Acute Allograft Rejection J. Immunol., November 15, 2001; 167(10): 5994 - 6001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Fleming, H. He, A. Ciota, D. Perkins, and P. W. Finn Administration of Pentoxifylline During Allergen Sensitization Dissociates Pulmonary Allergic Inflammation from Airway Hyperresponsiveness J. Immunol., August 1, 2001; 167(3): 1703 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. J. O'Neill The Interleukin-1 Receptor/Toll-like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense Sci. Signal., August 8, 2000; 2000(44): re1 - re1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Glimcher and K. M. Murphy Lineage commitment in the immune system: the T helper lymphocyte grows up Genes & Dev., July 15, 2000; 14(14): 1693 - 1711. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
