| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
Studies were undertaken to clarify the roles of individual leukocyte populations in maintaining the presence and organization of splenic dendritic cells (DCs). Using Abs specific for DC subsets, we found that the distinct types of DC maintained appropriate compartmentalization within the white pulp of lymphocyte-deficient mice despite an unusual overall distribution of DCs. Even in mice lacking both B and T lymphocytes, the central arteriole remained the structure around which T area DCs were organized. Marginal zone area DCs remained in a peripheral sheath excluded from the T area DCs. Additionally, we revealed an important role for splenic B cells in the presence and organization of marginal zone cells. B-deficient or B- and T-deficient mice lacked sialoadhesin+ marginal zone macrophages and lacked MAdCAM-1 expression in marginal zone reticular endothelial cells. Adoptive transfer of B lymphocytes induced MAdCAM-1 expression but failed to recruit marginal zone macrophages. Taken together, our results demonstrate that the arrival, localization, and persistence of DCs in spleen are events not solely dependent upon signals from the mature B and T cells or marginal zone macrophages. We suggest that specific stromal elements in the vicinity of the central arteriole are primarily responsible for providing directional cues to the DC.
This article has been cited by other articles:
|
|
 |
|
  Y. You, H. Zhao, Y. Wang, and R. H. Carter Cutting Edge: Primary and Secondary Effects of CD19 Deficiency on Cells of the Marginal Zone J. Immunol., June 15, 2009; 182(12): 7343 - 7347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. S. Ojalvo, W. King, D. Cox, and J. W. Pollard High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors Am. J. Pathol., March 1, 2009; 174(3): 1048 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-D. Bouaziz, K. Yanaba, G. M. Venturi, Y. Wang, R. M. Tisch, J. C. Poe, and T. F. Tedder Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice PNAS, December 26, 2007; 104(52): 20878 - 20883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Menard, L. A. Minns, S. Darche, D. W. Mielcarz, D. M. Foureau, D. Roos, F. Dzierszinski, L. H. Kasper, and D. Buzoni-Gatel B Cells Amplify IFN-{gamma} Production By T Cells via a TNF-{alpha}-Mediated Mechanism J. Immunol., October 1, 2007; 179(7): 4857 - 4866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Crawford, M. MacLeod, T. Schumacher, L. Corlett, and D. Gray Primary T Cell Expansion and Differentiation In Vivo Requires Antigen Presentation by B Cells J. Immunol., March 15, 2006; 176(6): 3498 - 3506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wakui, L. Morel, E. J. Butfiloski, C. Kim, and E. S. Sobel Genetic Dissection of Systemic Lupus Erythematosus Pathogenesis: Partial Functional Complementation between Sle1 and Sle3/5 Demonstrates Requirement for Intracellular Coexpression for Full Phenotypic Expression of Lupus J. Immunol., July 15, 2005; 175(2): 1337 - 1345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bayry, S. Lacroix-Desmazes, M. D. Kazatchkine, O. Hermine, D. F. Tough, and S. V. Kaveri Modulation of Dendritic Cell Maturation and Function by B Lymphocytes J. Immunol., July 1, 2005; 175(1): 15 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wen, S. A. Shinton, R. R. Hardy, and K. Hayakawa Association of B-1 B Cells with Follicular Dendritic Cells in Spleen J. Immunol., June 1, 2005; 174(11): 6918 - 6926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Bezbradica, A. K. Stanic, N. Matsuki, H. Bour-Jordan, J. A. Bluestone, J. W. Thomas, D. Unutmaz, L. Van Kaer, and S. Joyce Distinct Roles of Dendritic Cells and B Cells in Va14Ja18 Natural T Cell Activation In Vivo J. Immunol., April 15, 2005; 174(8): 4696 - 4705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Girkontaite, V. Sakk, M. Wagner, T. Borggrefe, K. Tedford, J. Chun, and K.-D. Fischer The Sphingosine-1-Phosphate (S1P) Lysophospholipid Receptor S1P3 Regulates MAdCAM-1+ Endothelial Cells in Splenic Marginal Sinus Organization J. Exp. Med., December 6, 2004; 200(11): 1491 - 1501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Reid, M. Montoya, P. R. Taylor, P. Borrow, S. Gordon, G. D. Brown, and S. Y. C. Wong Expression of the {beta}-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions J. Leukoc. Biol., July 1, 2004; 76(1): 86 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Nolte, R. Arens, M. Kraus, M. H. J. van Oers, G. Kraal, R. A. W. van Lier, and R. E. Mebius B Cells Are Crucial for Both Development and Maintenance of the Splenic Marginal Zone J. Immunol., March 15, 2004; 172(6): 3620 - 3627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Lemos, L. Fan, D. Lo, and T. M. Laufer CD8{alpha}+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity J. Immunol., November 15, 2003; 171(10): 5077 - 5084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Craxton, D. Magaletti, E. J. Ryan, and E. A. Clark Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF Blood, June 1, 2003; 101(11): 4464 - 4471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rizzitelli, R. Berthier, V. Collin, S. M. Candeias, and P. N. Marche T Lymphocytes Potentiate Murine Dendritic Cells to Produce IL-12 J. Immunol., October 15, 2002; 169(8): 4237 - 4245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Muller, L. Hunziker, S. Enzler, M. Buhler-Jungo, J. P. Di Santo, R. M. Zinkernagel, and C. Mueller Role of an Intact Splenic Microarchitecture in Early Lymphocytic Choriomeningitis Virus Production J. Virol., March 1, 2002; 76(5): 2375 - 2383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. del Hoyo, P. Martin, C. F. Arias, A. R. Marin, and C. Ardavin CD8alpha + dendritic cells originate from the CD8alpha - dendritic cell subset by a maturation process involving CD8alpha , DEC-205, and CD24 up-regulation Blood, February 1, 2002; 99(3): 999 - 1004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. N. Ngo, R. J. Cornall, and J. G. Cyster Splenic T Zone Development Is B Cell Dependent J. Exp. Med., December 3, 2001; 194(11): 1649 - 1660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Weih, Z. B. Yilmaz, and F. Weih Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines J. Immunol., August 15, 2001; 167(4): 1909 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Kirby, U. Yrlid, M. Svensson, and M. J. Wick Differential Involvement of Dendritic Cell Subsets During Acute Salmonella Infection J. Immunol., June 1, 2001; 166(11): 6802 - 6811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. E. A. Flesch, D. Stober, R. Schirmbeck, and J. Reimann Monocyte inflammatory protein-1{alpha} facilitates priming of CD8+ T cell responses to exogenous viral antigen Int. Immunol., September 1, 2000; 12(9): 1365 - 1370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Moulin, F. Andris, K. Thielemans, C. Maliszewski, J. Urbain, and M. Moser B Lymphocytes Regulate Dendritic Cell (DC) Function In Vivo: Increased Interleukin 12 Production by DCs from B Cell-deficient Mice Results in T Helper Cell Type 1 Deviation J. Exp. Med., August 14, 2000; 192(4): 475 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Fan, C. R. Reilly, Y. Luo, M. E. Dorf, and D. Lo Cutting Edge: Ectopic Expression of the Chemokine TCA4/SLC Is Sufficient to Trigger Lymphoid Neogenesis J. Immunol., April 15, 2000; 164(8): 3955 - 3959. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
