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CUTTING EDGE |
*
Division of Immunology and
Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom;
Basel Institute for Immunology, Basel, Switzerland; and
§
Cell Biophysics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
Transmembrane adapter proteins are a class of molecules
that mediate signals from an extracellular receptor to the cytoplasm of
the cell. We have cloned a novel transmembrane adapter protein called
KAP10, a 
10-kDa protein that is encoded within 100 bp of the DAP12
locus on human chromosome 19. KAP10 is predominantly expressed in
immune cells, including NK cells, T cells, and monocytes. We show that
KAP10, unlike other transmembrane adapter proteins, binds
phosphatidylinositol-3 kinase following phosphorylation
of a cytoplasmic YINM motif, which results in activation of Akt. In
addition, we identify KAP10 as being able to bind the adapter protein
Grb2. Based on our data, we suggest that this molecule is involved in
stimulation and costimulation in cells of both myeloid and lymphoid
origin.
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