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CUTTING EDGE |
*
Department of Molecular Biology, Princeton University, Princeton, NJ 08544;
Institut National de la Santé et de la Recherche Médicale U25, Hopital Necker, Paris, France; and
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd, Gunma, Japan
-Galactosylceramide (-GalCer) is a glycolipid with potent
antitumor properties that binds to CD1d molecules and activates mouse
V14 and human V24 NKT cells. Surprisingly, we found that, as
early as 90 min after -GalCer injection in vivo, NK cells also
displayed considerable signs of activation, including IFN-
production and CD69 induction. NK activation was not observed in RAG-
or CD1-deficient mice, and it was decreased by pretreatment with
anti-IFN- Abs, suggesting that, despite its rapid induction, it
was a secondary event that depended on IFN- release by NKT cells. At
later time points, B cells and CD8 T cells also began to express CD69.
These findings identify a high-speed communication network between the
innate and adaptive immune systems in vivo that is initiated upon NKT
cell activation. They also suggest that the antitumor effects of
-GalCer result from the sequential recruitment of distinct
innate and adaptive effector lymphocytes.
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T. Osada, M. A. Morse, H. K. Lyerly, and T. M. Clay Ex vivo expanded human CD4+ regulatory NKT cells suppress expansion of tumor antigen-specific CTLs Int. Immunol., September 1, 2005; 17(9): 1143 - 1155. [Abstract] [Full Text] [PDF]
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S. C. Yue, A. Shaulov, R. Wang, S. P. Balk, and M. A. Exley CD1d ligation on human monocytes directly signals rapid NF-{kappa}B activation and production of bioactive IL-12 PNAS, August 16, 2005; 102(33): 11811 - 11816. [Abstract] [Full Text] [PDF]
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M. Biburger and G. Tiegs {alpha}-Galactosylceramide-Induced Liver Injury in Mice Is Mediated by TNF-{alpha} but Independent of Kupffer Cells J. Immunol., August 1, 2005; 175(3): 1540 - 1550. [Abstract] [Full Text] [PDF]
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C. Forestier, A. Molano, J. S. Im, Y. Dutronc, B. Diamond, A. Davidson, P. A. Illarionov, G. S. Besra, and S. A. Porcelli Expansion and Hyperactivity of CD1d-Restricted NKT Cells during the Progression of Systemic Lupus Erythematosus in (New Zealand Black x New Zealand White)F1 Mice J. Immunol., July 15, 2005; 175(2): 763 - 770. [Abstract] [Full Text] [PDF]
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Y. Geng, P. Laslo, K. Barton, and C.-R. Wang Transcriptional Regulation of CD1D1 by Ets Family Transcription Factors J. Immunol., July 15, 2005; 175(2): 1022 - 1029. [Abstract] [Full Text] [PDF]
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T. Ranson, S. Bregenholt, A. Lehuen, O. Gaillot, M. C. Leite-de-Moraes, A. Herbelin, P. Berche, and J. P. Di Santo Invariant V{alpha}14+ NKT Cells Participate in the Early Response to Enteric Listeria monocytogenes Infection J. Immunol., July 15, 2005; 175(2): 1137 - 1144. [Abstract] [Full Text] [PDF]
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M. J. Smyth, M. E. Wallace, S. L. Nutt, H. Yagita, D. I. Godfrey, and Y. Hayakawa Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer J. Exp. Med., June 20, 2005; 201(12): 1973 - 1985. [Abstract] [Full Text] [PDF]
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D. H. Chang, K. Osman, J. Connolly, A. Kukreja, J. Krasovsky, M. Pack, A. Hutchinson, M. Geller, N. Liu, R. Annable, et al. Sustained expansion of NKT cells and antigen-specific T cells after injection of {alpha}-galactosyl-ceramide loaded mature dendritic cells in cancer patients J. Exp. Med., May 2, 2005; 201(9): 1503 - 1517. [Abstract] [Full Text] [PDF]
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M. S. Duthie and S. J. Kahn NK cell activation and protection occur independently of natural killer T cells during Trypanosoma cruzi infection Int. Immunol., May 1, 2005; 17(5): 607 - 613. [Abstract] [Full Text] [PDF]
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B. Chung, A. Aoukaty, J. Dutz, C. Terhorst, and R. Tan Cutting Edge: Signaling Lymphocytic Activation Molecule-Associated Protein Controls NKT Cell Functions J. Immunol., March 15, 2005; 174(6): 3153 - 3157. [Abstract] [Full Text] [PDF]
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K. O. A. Yu, J. S. Im, A. Molano, Y. Dutronc, P. A. Illarionov, C. Forestier, N. Fujiwara, I. Arias, S. Miyake, T. Yamamura, et al. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of {alpha}-galactosylceramides PNAS, March 1, 2005; 102(9): 3383 - 3388. [Abstract] [Full Text] [PDF]
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A. Ishikawa, S. Motohashi, E. Ishikawa, H. Fuchida, K. Higashino, M. Otsuji, T. Iizasa, T. Nakayama, M. Taniguchi, and T. Fujisawa A Phase I Study of {alpha}-Galactosylceramide (KRN7000)-Pulsed Dendritic Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer Clin. Cancer Res., March 1, 2005; 11(5): 1910 - 1917. [Abstract] [Full Text] [PDF]
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S. Korten, R. J. Anderson, C. M. Hannan, E. G. Sheu, R. Sinden, S. Gadola, M. Taniguchi, and A. V. S. Hill Invariant V{alpha}14 Chain NKT Cells Promote Plasmodium berghei Circumsporozoite Protein-Specific Gamma Interferon- and Tumor Necrosis Factor Alpha-Producing CD8+ T Cells in the Liver after Poxvirus Vaccination of Mice Infect. Immun., February 1, 2005; 73(2): 849 - 858. [Abstract] [Full Text] [PDF]
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J. Schmieg, G. Yang, R. W. Franck, N. Van Rooijen, and M. Tsuji Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion PNAS, January 25, 2005; 102(4): 1127 - 1132. [Abstract] [Full Text] [PDF]
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 J. Loh, D. T. Chu, A. K. O'Guin, W. M. Yokoyama, and H. W. Virgin IV Natural Killer Cells Utilize both Perforin and Gamma Interferon To Regulate Murine Cytomegalovirus Infection in the Spleen and Liver J. Virol., January 1, 2005; 79(1): 661 - 667. [Abstract] [Full Text] [PDF]
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T. Crough, M. Nieda, and A. J. Nicol Granulocyte Colony-Stimulating Factor Modulates {alpha}-Galactosylceramide-Responsive Human V{alpha}24+V{beta}11+ NKT Cells J. Immunol., October 15, 2004; 173(8): 4960 - 4966. [Abstract] |
