| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
*
Pulmonary Division, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109;
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190;
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599; and
§
Department of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712
After intratracheal inoculation of the AIDS-associated pathogen Cryptococcus neoformans, 12-wk survival was >90% for CCR5+/+ mice but <25% for CCR5-/- mice. There were no defects in lung leukocyte recruitment (wk 5), pulmonary clearance, or delayed-type hypersensitivity in CCR5-/- mice. However, CCR5-/- mice had defects in leukocyte recruitment into the brain and, strikingly, in elimination of cryptococcal polysaccharide from the brain. In nonimmune CCR5-/- mice, there was a significant defect in macrophage recruitment after challenge with shed cryptococcal products (C. neoformans filtrate Ag) but not other nonspecific stimuli. Thus, CCR5 plays specific roles in innate immunity and organ-specific leukocyte trafficking during host defense against C. neoformans.
This article has been cited by other articles:
|
|
 |
|
  D. Zhao, C. Zhang, T. Yi, C.-L. Lin, I. Todorov, F. Kandeel, S. Forman, and D. Zeng In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease Blood, September 1, 2008; 112(5): 2129 - 2138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Osterholzer, J. L. Curtis, T. Polak, T. Ames, G.-H. Chen, R. McDonald, G. B. Huffnagle, and G. B. Toews CCR2 Mediates Conventional Dendritic Cell Recruitment and the Formation of Bronchovascular Mononuclear Cell Infiltrates in the Lungs of Mice Infected with Cryptococcus neoformans J. Immunol., July 1, 2008; 181(1): 610 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kallikourdis, K. G. Andersen, K. A. Welch, and A. G. Betz Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus PNAS, January 9, 2007; 104(2): 594 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Venkataramana, C. A. Pardo, J. C. McArthur, D. A. Kerr, D. N. Irani, J. W. Griffin, P. Burger, D. S. Reich, P. A. Calabresi, and A. Nath Immune reconstitution inflammatory syndrome in the CNS of HIV-infected patients Neurology, August 8, 2006; 67(3): 383 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zernecke, E. A. Liehn, J.-L. Gao, W. A. Kuziel, P. M. Murphy, and C. Weber Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10 Blood, June 1, 2006; 107(11): 4240 - 4243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ma, W. Liu, R. J. Homer, P. J. Lee, A. J. Coyle, J. M. Lora, C. G. Lee, and J. A. Elias Role of CCR5 in the Pathogenesis of IL-13-Induced Inflammation and Remodeling. J. Immunol., April 15, 2006; 176(8): 4968 - 4978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. J. Carr, J. Ash, T. E. Lane, and W. A. Kuziel Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1. J. Gen. Virol., March 1, 2006; 87(Pt 3): 489 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Hardison, R. A. Wrightsman, P. M. Carpenter, W. A. Kuziel, T. E. Lane, and J. E. Manning The CC Chemokine Receptor 5 Is Important in Control of Parasite Replication and Acute Cardiac Inflammation following Infection with Trypanosoma cruzi Infect. Immun., January 1, 2006; 74(1): 135 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Wysocki, Q. Jiang, A. Panoskaltsis-Mortari, P. A. Taylor, K. P. McKinnon, L. Su, B. R. Blazar, and J. S. Serody Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease Blood, November 1, 2005; 106(9): 3300 - 3307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. G. Glass, J. K. Lim, R. Cholera, A. G. Pletnev, J.-L. Gao, and P. M. Murphy Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection J. Exp. Med., October 17, 2005; 202(8): 1087 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takashima, H. Miyake, N. Kanzaki, Y. Tagawa, X. Wang, Y. Sugihara, Y. Iizawa, and M. Baba Highly Potent Inhibition of Human Immunodeficiency Virus Type 1 Replication by TAK-220, an Orally Bioavailable Small-Molecule CCR5 Antagonist Antimicrob. Agents Chemother., August 1, 2005; 49(8): 3474 - 3482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ank, K. Petersen, L. Malmgaard, S. C. Mogensen, and S. R. Paludan Age-Dependent Role for CCR5 in Antiviral Host Defense against Herpes Simplex Virus Type 2 J. Virol., August 1, 2005; 79(15): 9831 - 9841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Scott Algood and J. L. Flynn CCR5-Deficient Mice Control Mycobacterium tuberculosis Infection despite Increased Pulmonary Lymphocytic Infiltration J. Immunol., September 1, 2004; 173(5): 3287 - 3296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Peterson, J. S. Errett, T. Wei, D. E. Dimcheff, R. Ransohoff, W. A. Kuziel, L. Evans, and B. Chesebro MCP-1 and CCR2 Contribute to Non-Lymphocyte-Mediated Brain Disease Induced by Fr98 Polytropic Retrovirus Infection in Mice: Role for Astrocytes in Retroviral Neuropathogenesis J. Virol., June 15, 2004; 78(12): 6449 - 6458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. X. Zhong, W. A. Kuziel, E. G. Pamer, and N. V. Serbina Chemokine Receptor 5 Is Dispensable for Innate and Adaptive Immune Responses to Listeria monocytogenes Infection Infect. Immun., February 1, 2004; 72(2): 1057 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Eis, B. Luckow, V. Vielhauer, J. T. Siveke, Y. Linde, S. Segerer, G. P. de Lema, C. D. Cohen, M. Kretzler, M. Mack, et al. Chemokine Receptor CCR1 But Not CCR5 Mediates Leukocyte Recruitment and Subsequent Renal Fibrosis after Unilateral Ureteral Obstruction J. Am. Soc. Nephrol., February 1, 2004; 15(2): 337 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Szabo, M. A. Wetzel, N. Zhang, A. D. Steele, D. E. Kaminsky, C. Chen, L.-Y. Liu-Chen, F. Bednar, E. E. Henderson, O. M. Z. Howard, et al. Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization J. Leukoc. Biol., December 1, 2003; 74(6): 1074 - 1082. [Abstract] [Full Text]
|
|
|
|
|
|
E. Belnoue, M. Kayibanda, J.-C. Deschemin, M. Viguier, M. Mack, W. A. Kuziel, and L. Renia CCR5 deficiency decreases susceptibility to experimental cerebral malaria Blood, June 1, 2003; 101(11): 4253 - 4259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Cardona, P. A. Gonzalez, and J. M. Teale CC Chemokines Mediate Leukocyte Trafficking into the Central Nervous System during Murine Neurocysticercosis: Role of {gamma}{delta} T Cells in Amplification of the Host Immune Response Infect. Immun., May 1, 2003; 71(5): 2634 - 2642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Ambati, A. Anand, A. M. Joussen, W. A. Kuziel, A. P. Adamis, and J. Ambati Sustained Inhibition of Corneal Neovascularization by Genetic Ablation of CCR5 Invest. Ophthalmol. Vis. Sci., February 1, 2003; 44(2): 590 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Glass and T. E. Lane Functional Expression of Chemokine Receptor CCR5 on CD4+ T Cells during Virus-Induced Central Nervous System Disease J. Virol., December 6, 2002; 77(1): 191 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nansen, J. P. Christensen, S. O. Andreasen, C. Bartholdy, J. E. Christensen, and A. R. Thomsen The role of CC chemokine receptor 5 in antiviral immunity Blood, February 15, 2002; 99(4): 1237 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Moore, R. Paine III, P. J. Christensen, T. A. Moore, S. Sitterding, R. Ngan, C. A. Wilke, W. A. Kuziel, and G. B. Toews Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling J. Immunol., October 15, 2001; 167(8): 4368 - 4377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Chen, W. A. Kuziel, and T. E. Lane Lack of CCR2 Results in Increased Mortality and Impaired Leukocyte Activation and Trafficking Following Infection of the Central Nervous System with a Neurotropic Coronavirus J. Immunol., October 15, 2001; 167(8): 4585 - 4592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Strizki, S. Xu, N. E. Wagner, L. Wojcik, J. Liu, Y. Hou, M. Endres, A. Palani, S. Shapiro, J. W. Clader, et al. SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo PNAS, October 12, 2001; (2001) 221375398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Olszewski, G. B. Huffnagle, T. R. Traynor, R. A. McDonald, D. N. Cook, and G. B. Toews Regulatory Effects of Macrophage Inflammatory Protein 1{alpha}/CCL3 on the Development of Immunity to Cryptococcus neoformans Depend on Expression of Early Inflammatory Cytokines Infect. Immun., October 1, 2001; 69(10): 6256 - 6263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mack, J. Cihak, C. Simonis, B. Luckow, A. E. I. Proudfoot, H. Bruhl, M. Frink, H.-J. Anders, V. Vielhauer, J. Pfirstinger, et al. Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice J. Immunol., April 1, 2001; 166(7): 4697 - 4704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Goldman, X. Song, R. Kitai, A. Casadevall, M.-L. Zhao, and S. C. Lee Cryptococcus neoformans Induces Macrophage Inflammatory Protein 1{alpha} (MIP-1{alpha}) and MIP-1{beta} in Human Microglia: Role of Specific Antibody and Soluble Capsular Polysaccharide Infect. Immun., March 1, 2001; 69(3): 1808 - 1815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Unutmaz, W. Xiang, M. J. Sunshine, J. Campbell, E. Butcher, and D. R. Littman The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse J. Immunol., September 15, 2000; 165(6): 3284 - 3292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Blease, B. Mehrad, T. J. Standiford, N. W. Lukacs, J. Gosling, L. Boring, I. F. Charo, S. L. Kunkel, and C. M. Hogaboam Enhanced Pulmonary Allergic Responses to Aspergillus in CCR2-/- Mice J. Immunol., September 1, 2000; 165(5): 2603 - 2611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Dawson, M. A. Beck, W. A. Kuziel, F. Henderson, and N. Maeda Contrasting Effects of CCR5 and CCR2 Deficiency in the Pulmonary Inflammatory Response to Influenza A Virus Am. J. Pathol., June 1, 2000; 156(6): 1951 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors Pharmacol. Rev., March 1, 2000; 52(1): 145 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sato, W. A. Kuziel, P. C. Melby, R. L. Reddick, V. Kostecki, W. Zhao, N. Maeda, S. K. Ahuja, and S. S. Ahuja Defects in the Generation of IFN-{gamma} Are Overcome to Control Infection with Leishmania donovani in CC Chemokine Receptor (CCR) 5-, Macrophage Inflammatory Protein-1{alpha}-, or CCR2-Deficient Mice J. Immunol., November 15, 1999; 163(10): 5519 - 5525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Dragic, A. Trkola, D. A. D. Thompson, E. G. Cormier, F. A. Kajumo, E. Maxwell, S. W. Lin, W. Ying, S. O. Smith, T. P. Sakmar, et al. A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5 PNAS, May 9, 2000; 97(10): 5639 - 5644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Strizki, S. Xu, N. E. Wagner, L. Wojcik, J. Liu, Y. Hou, M. Endres, A. Palani, S. Shapiro, J. W. Clader, et al. SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo PNAS, October 23, 2001; 98(22): 12718 - 12723. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
