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Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756
Immunization of mice with a vaccine (ts-4) strain of
Toxoplasma gondii is known to induce complete protection
against subsequent lethal infection. Ts-4-mediated protection has been
reported to be primarily dependent on IFN-
-producing
CD8+ T cells. However, duration of CD8+ T
cell-mediated immunity in the ts-4-vaccinated animals is not known. In
the present study, the kinetics of the CD8+ T cell response
in mice immunized with the ts-4 strain of T. gondii was
evaluated. Optimal CD8+ T cell immunity persisted at least
6 mo after vaccination, and mice at this time point continued to
overcome lethal challenge with a more virulent strain. However, at 9 mo
postimmunization, CD8+ T cell immunity was severely
diminished and the mice succumbed to Toxoplasma
challenge. Pretreatment of animals, vaccinated 9 mo earlier, with
rIL-15 prevented the mortality induced by Toxoplasma
challenge. The protective effect of IL-15 treatment was due to a rise
in the frequency of Ag-specific CD8+ T cells.
CD8+ T cells from IL-15-administered animals showed
increased proliferation and IFN- production in response to antigenic
restimulation. These findings suggest that rIL-15 can reverse the
decline in the long-term CD8+ T cell immune response in
mice immunized with vaccine strain of T.
gondii.
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