| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
*
Department of Medicine, Northport Veterans Affairs Medical Center, Northport, NY 11768;
Department of Pathology, State University of New York, Stony Brook, NY 11794;
Laboratoire de Virologie et d’Immunologie Moleculaire, Institut National de la Recherche Agronomique, C. R. J. Domaine de Vilvert, Jouy-en-Josas, France; and
§
Departments of Medicine and Microbiology, Palo Alto Veterans Affairs Medical Center and Stanford University, Stanford, CA 94305
Rotavirus is the most important worldwide cause of severe
gastroenteritis in infants and young children. Intestinal epithelial
cells are the principal targets of rotavirus infection, but the
response of enterocytes to rotavirus infection is largely unknown. We
determined that rotavirus infection of HT-29 intestinal epithelial
cells results in prompt activation of NF-
B (<2 h), STAT1, and ISG
F3 (3 h). Genetically inactivated rotavirus and virus-like particles
assembled from baculovirus-expressed viral proteins also activated
NF-B. Rotavirus infection of HT-29 cells induced mRNA for several
C-C and C-X-C chemokines as well as IFNs and GM-CSF. Mice infected with
simian rotavirus or murine rotavirus responded similarly with the
enhanced expression of a profile of C-C and C-X-C chemokines. The
rotavirus-stimulated increase in chemokine mRNA was undiminished in
mice lacking mast cells or lymphocytes. Rotavirus induced chemokines
only in mice <15 days of age despite documented infection in older
mice. Macrophage inflammatory protein-1ß and IFN-stimulated protein
10 mRNA responses occurred, but were reduced in p50-/-
mice. Macrophage inflammatory protein-1ß expression during rotavirus
infection localized to the intestinal epithelial cell in murine
intestine. These results show that the intestinal epithelial cell is an
active component of the host response to rotavirus
infection.
This article has been cited by other articles:
|
|
 |
|
  M. A. Borghan, Y. Mori, A.-B. El-Mahmoudy, N. Ito, M. Sugiyama, T. Takewaki, and N. Minamoto Induction of nitric oxide synthase by rotavirus enterotoxin NSP4: implication for rotavirus pathogenicity J. Gen. Virol., July 1, 2007; 88(7): 2064 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Smiley, M. M. McNeal, M. Basu, A. H.-C. Choi, J. D. Clements, and R. L. Ward Association of Gamma Interferon and Interleukin-17 Production in Intestinal CD4+ T Cells with Protection against Rotavirus Shedding in Mice Intranasally Immunized with VP6 and the Adjuvant LT(R192G) J. Virol., April 15, 2007; 81(8): 3740 - 3748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Douagi, G. M. McInerney, A. S. Hidmark, V. Miriallis, K. Johansen, L. Svensson, and G. B. Karlsson Hedestam Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts J. Virol., March 15, 2007; 81(6): 2758 - 2768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kordasti, C. Istrate, M. Banasaz, M. Rottenberg, H. Sjovall, O. Lundgren, and L. Svensson Rotavirus Infection Is Not Associated with Small Intestinal Fluid Secretion in the Adult Mouse J. Virol., November 15, 2006; 80(22): 11355 - 11361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Holloway and B. S. Coulson Rotavirus Activates JNK and p38 Signaling Pathways in Intestinal Cells, Leading to AP-1-Driven Transcriptional Responses and Enhanced Virus Replication J. Virol., November 1, 2006; 80(21): 10624 - 10633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. Wolber, A. M. Broomfield, L. Fray, M. L. Cross, and D. Dey Supplemental Dietary Whey Protein Concentrate Reduces Rotavirus-Induced Disease Symptoms in Suckling Mice J. Nutr., June 1, 2005; 135(6): 1470 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Vijay-Kumar, J. R. Gentsch, W. J. Kaiser, N. Borregaard, M. K. Offermann, A. S. Neish, and A. T. Gewirtz Protein Kinase R Mediates Intestinal Epithelial Gene Remodeling in Response to Double-Stranded RNA and Live Rotavirus J. Immunol., May 15, 2005; 174(10): 6322 - 6331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Rollo, S. J. Hempson, A. Bansal, E. Tsao, I. Habib, S. R. Rittling, D. T. Denhardt, E. R. Mackow, and R. D. Shaw The Cytokine Osteopontin Modulates the Severity of Rotavirus Diarrhea J. Virol., March 15, 2005; 79(6): 3509 - 3516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Ramig Pathogenesis of Intestinal and Systemic Rotavirus Infection J. Virol., October 1, 2004; 78(19): 10213 - 10220. [Full Text] [PDF]
|
|
|
|
|
|
J. W. A. Rossen, J. Bouma, R. H. C. Raatgeep, H. A. Buller, and A. W. C. Einerhand Inhibition of Cyclooxygenase Activity Reduces Rotavirus Infection at a Postbinding Step J. Virol., September 15, 2004; 78(18): 9721 - 9730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Caballero, F. X. Abad, F. Loisy, F. S. Le Guyader, J. Cohen, R. M. Pinto, and A. Bosch Rotavirus Virus-Like Particles as Surrogates in Environmental Persistence and Inactivation Studies Appl. Envir. Microbiol., July 1, 2004; 70(7): 3904 - 3909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. G. Dickman, J. G. Youssef, S. M. Mathew, and S. I. Said Ionotropic Glutamate Receptors in Lungs and Airways: Molecular Basis for Glutamate Toxicity Am. J. Respir. Cell Mol. Biol., February 1, 2004; 30(2): 139 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Boshuizen, J. H. J. Reimerink, A. M. Korteland-van Male, V. J. J. van Ham, M. P. G. Koopmans, H. A. Buller, J. Dekker, and A. W. C. Einerhand Changes in Small Intestinal Homeostasis, Morphology, and Gene Expression during Rotavirus Infection of Infant Mice J. Virol., December 15, 2003; 77(24): 13005 - 13016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Graff, D. N. Mitzel, C. M. Weisend, M. L. Flenniken, and M. E. Hardy Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1 J. Virol., August 12, 2002; 76(18): 9545 - 9550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Abreu, E. T. Arnold, L. S. Thomas, R. Gonsky, Y. Zhou, B. Hu, and M. Arditi TLR4 and MD-2 Expression Is Regulated by Immune-mediated Signals in Human Intestinal Epithelial Cells J. Biol. Chem., May 31, 2002; 277(23): 20431 - 20437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lacroix-Lamande, R. Mancassola, M. Naciri, and F. Laurent Role of Gamma Interferon in Chemokine Expression in the Ileum of Mice and in a Murine Intestinal Epithelial Cell Line after Cryptosporidium parvum Infection Infect. Immun., April 1, 2002; 70(4): 2090 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Cuadras, D. A. Feigelstock, S. An, and H. B. Greenberg Gene Expression Pattern in Caco-2 Cells following Rotavirus Infection J. Virol., March 27, 2002; 76(9): 4467 - 4482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ciarlet, S. E. Crawford, E. Cheng, S. E. Blutt, D. A. Rice, J. M. Bergelson, and M. K. Estes VLA-2 ({alpha}2{beta}1) Integrin Promotes Rotavirus Entry into Cells but Is Not Necessary for Rotavirus Attachment J. Virol., February 1, 2002; 76(3): 1109 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ciarlet, S. E. Crawford, and M. K. Estes Differential Infection of Polarized Epithelial Cell Lines by Sialic Acid-Dependent and Sialic Acid-Independent Rotavirus Strains J. Virol., December 1, 2001; 75(23): 11834 - 11850. [Abstract] [Full Text]
|
|
|
|
|
|
R. LaMonica, S. S. Kocer, J. Nazarova, W. Dowling, E. Geimonen, R. D. Shaw, and E. R. Mackow VP4 Differentially Regulates TRAF2 Signaling, Disengaging JNK Activation while Directing NF-kappa B to Effect Rotavirus-specific Cellular Responses J. Biol. Chem., June 1, 2001; 276(23): 19889 - 19896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Charpilienne, M. Nejmeddine, M. Berois, N. Parez, E. Neumann, E. Hewat, G. Trugnan, and J. Cohen Individual Rotavirus-like Particles Containing 120 Molecules of Fluorescent Protein Are Visible in Living Cells J. Biol. Chem., July 27, 2001; 276(31): 29361 - 29367. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
