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Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030
Whether CD8 T cell memory exists outside secondary lymphoid organs
is unclear. Using an adoptive transfer system that enables tracking of
OVA-specific CD8 T cells, we explored the antigenic requirements for
inducing CD8 T cell memory and identified intestinal mucosa memory
cells. Although systemic immunization with soluble OVA induced clonal
expansion, memory CD8 cells were not produced. In contrast, infection
with virus-encoding OVA induced memory CD8 cells in the periphery and
the lamina propria and intraepithelial compartments of the intestinal
mucosa. Mucosal memory cells expressed a distinct array of adhesion
molecules as compared with secondary lymphoid memory cells, suggesting
that there may be separate mucosal and systemic memory pools. Mucosal
CD8 memory cells rapidly produced IFN-
after Ag stimulation.
Reactivation of memory cells by Ag feeding resulted in increased cell
size and up-regulation of CD28 and CD11c. CD8 mucosal memory cells
exhibited ex vivo lytic activity that was up-regulated dramatically
following Ag reencounter in vivo. Interestingly, reactivation of memory
cells did not require CD28-mediated costimulation. The ability of the
intestinal mucosa to maintain CD8 memory cells provides a potential
mechanism for effective mucosal vaccination.
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