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CUTTING EDGE |
ß+ CD8+ T Cells Are Found in Intestinal Intraepithelial Lymphocytes of Mice That Lack Classical MHC Class I Molecules1
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121
TCR
ß+ intestinal intraepithelial lymphocytes
(IEL) can express either the typical CD8ß heterodimer or an
unusual CD8 homodimer. Both types of
CD8+ IEL require class I molecules for
their differentiation, since they are absent in
ß2m-/- mice. To gain insight into the role
of class I molecules in forming TCRß+
CD8+ IEL populations, we have analyzed
the IEL in mice deficient for either TAP, ß2m, CD1, or K
and D. We find that K-/-D-/- mice have
TCRß+
CD8+ IEL, although they are
deficient for TCRß+
CD8ß+ cells. This indicates that at
least some TCRß+
CD8+ IEL require only nonclassical
class I molecules for their development. Surprisingly, the
TCRß+
CD8+ IEL are significantly
increased in K-/-D-/- mice, suggesting a
complex interaction between CD8+ IEL and class I molecules
that might include direct or indirect negative regulation by K
and D, as well as positive effects mediated by nonclassical class I
molecules.
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