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The Journal of Immunology, 1999, 163: 4100-4104.
Copyright © 1999 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: TCR{alpha}ß+ CD8{alpha}{alpha}+ T Cells Are Found in Intestinal Intraepithelial Lymphocytes of Mice That Lack Classical MHC Class I Molecules1

Laurent Gapin, Hilde Cheroutre and Mitchell Kronenberg2

Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121

TCR{alpha}ß+ intestinal intraepithelial lymphocytes (IEL) can express either the typical CD8{alpha}ß heterodimer or an unusual CD8{alpha}{alpha} homodimer. Both types of CD8+ IEL require class I molecules for their differentiation, since they are absent in ß2m-/- mice. To gain insight into the role of class I molecules in forming TCR{alpha}ß+ CD8+ IEL populations, we have analyzed the IEL in mice deficient for either TAP, ß2m, CD1, or K and D. We find that K-/-D-/- mice have TCR{alpha}ß+ CD8{alpha}{alpha}+ IEL, although they are deficient for TCR{alpha}ß+ CD8{alpha}ß+ cells. This indicates that at least some TCR{alpha}ß+ CD8{alpha}{alpha}+ IEL require only nonclassical class I molecules for their development. Surprisingly, the TCR{alpha}ß+ CD8{alpha}{alpha}+ IEL are significantly increased in K-/-D-/- mice, suggesting a complex interaction between CD8+ IEL and class I molecules that might include direct or indirect negative regulation by K and D, as well as positive effects mediated by nonclassical class I molecules.




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