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CUTTING EDGE |
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
Most NK1.1+ T (NKT) cells express a biased TCR
ß
repertoire that is positively selected by the monomorphic MHC class
I-like molecule CD1d. The development of CD1d-dependent NKT cells is
thymus dependent but, in contrast to conventional T cells, requires
positive selection by cells of hemopoietic origin. Here, we show that
the Src protein tyrosine kinase Fyn is required for development of
CD1d-dependent NKT cells but not for the development of conventional T
cells. In contrast, another Src kinase, Lck, is required for the
development of both NKT and T cells. Impaired NKT cell
development in Fyn-deficient mice cannot be rescued by transgenic
expression of CD8, which is believed to increase the avidity of CD1d
recognition by NKT cells. Taken together, our data reveal a selective
and nonredundant role for Fyn in NKT cell
development.
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