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The Journal of Immunology, 1999, 163: 4087-4090.
Copyright © 1999 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Paradigm Revisited: Antibody Provides Resistance to Listeria Infection1

Brian T. Edelson*, Pascale Cossart{dagger} and Emil R. Unanue2,*

* Center for Immunology and Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110; and {dagger} Unite des Interactions Bacteries Cellules, Institut Pasteur, Paris, France

Listeriolysin O (LLO) is a secreted pore-forming toxin of the facultative intracellular bacterium Listeria monocytogenes. We assessed the ability of a murine anti-LLO mAb to affect the course of infection in mice challenged with Listeria. This mAb was previously shown to be capable of neutralizing LLO-mediated pore formation in vitro, and here we show that the passive administration of this Ab to mice before infection provides increased resistance. Mice treated with the mAb were protected from a lethal challenge with virulent Listeria and showed a significant reduction in Listeria burden during the first hours to days postinfection. These effects of the Ab were independent of host B or T cells, since treatment with the mAb provided enhanced resistance to SCID mice. The titer of anti-LLO Abs during the regular infection of mice with Listeria was found to be low to negative.




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