The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ying, S.
Right arrow Articles by Kay, A. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ying, S.
Right arrow Articles by Kay, A. B.
The Journal of Immunology, 1999, 163: 3976-3984.
Copyright © 1999 by The American Association of Immunologists

C-C Chemokines in Allergen-Induced Late-Phase Cutaneous Responses in Atopic Subjects: Association of Eotaxin with Early 6-Hour Eosinophils, and of Eotaxin-2 and Monocyte Chemoattractant Protein-4 with the Later 24-Hour Tissue Eosinophilia, and Relationship to Basophils and Other C-C Chemokines (Monocyte Chemoattractant Protein-3 and RANTES)1

Sun Ying*, Douglas S. Robinson*, Qiu Meng*, Luis T. Barata*, Alan R. McEuen{dagger}, Mark G. Buckley{dagger}, Andrew F. Walls{dagger}, Philip W. Askenase* and A. Barry Kay2,*

* Department of Allergy and Clinical Immunology, Imperial College School of Medicine, Royal Brompton Campus, National Heart and Lung Institute, London, United Kingdom; and {dagger} Southampton General Hospital, Southampton, United Kingdom

The relationship of expression of the C-C chemokines eotaxin, eotaxin 2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4 to the kinetics of infiltrating eosinophils, basophils, and other inflammatory cells was examined in allergen-induced, late-phase allergic reactions in the skin of human atopic subjects. EG2+ eosinophils peaked at 6 h and correlated significantly with eotaxin mRNA and protein, whereas declining eosinophils at 24 h correlated significantly with eotaxin-2 and MCP-4 mRNA. In contrast, no significant correlations were observed between BB1+ basophil infiltrates, which peaked at 24 h, and expression of eotaxin, eotaxin-2, RANTES, MCP-3, and MCP-4 or elastase+ neutrophils (6-h peak), CD3+ and CD4+ T cells (24 h), and CD68+ macrophages (72 h). Furthermore, 83% of eosinophils, 40% of basophils, and 1% of CD3+ cells expressed the eotaxin receptor CCR3, while eotaxin protein was expressed by 43% of macrophages, 81% of endothelial cells, and 6% of T cells (6%). These data suggest that 1) eotaxin has a role in the early 6-h recruitment of eosinophils, while eotaxin-2 and MCP-4 appear to be involved in later 24-h infiltration of these CCR3+ cells; 2) different mechanisms may guide the early vs late eosinophilia; and 3) other chemokines and receptors may be involved in basophil accumulation of allergic tissue reactions in human skin.




This article has been cited by other articles:


Home page
 ChestHome page
H.-B. Kim, C.-K. Kim, K. Iijima, T. Kobayashi, and H. Kita
Protein Microarray Analysis in Patients With Asthma: Elevation of the Chemokine PARC/CCL18 in Sputum
Chest, February 1, 2009; 135(2): 295 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. J. Haley, M. E. Sunday, Y. Porrata, C. Kelley, A. Twomey, A. Shahsafaei, B. Galper, L. A. Sonna, and C. M. Lilly
Ontogeny of the eotaxins in human lung
Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L214 - L224.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. I. Ochkur, E. A. Jacobsen, C. A. Protheroe, T. L. Biechele, R. S. Pero, M. P. McGarry, H. Wang, K. R. O'Neill, D. C. Colbert, T. V. Colby, et al.
Coexpression of IL-5 and Eotaxin-2 in Mice Creates an Eosinophil-Dependent Model of Respiratory Inflammation with Characteristics of Severe Asthma
J. Immunol., June 15, 2007; 178(12): 7879 - 7889.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. E. Scheicher, M. M. Teixeira, F. Q. Cunha, A. L. Teixeira Jr, J. T. Filho, and E. O. Vianna
Eotaxin-2 in sputum cell culture to evaluate asthma inflammation
Eur. Respir. J., March 1, 2007; 29(3): 489 - 495.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. de Paulis, N. Prevete, I. Fiorentino, F. W. Rossi, S. Staibano, N. Montuori, P. Ragno, A. Longobardi, B. Liccardo, A. Genovese, et al.
Expression and Functions of the Vascular Endothelial Growth Factors and Their Receptors in Human Basophils
J. Immunol., November 15, 2006; 177(10): 7322 - 7331.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Fan, N. M. Heller, M. Gorospe, U. Atasoy, and C. Stellato
The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy
Eur. Respir. J., November 1, 2005; 26(5): 933 - 947.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. M. Pope, N. Zimmermann, K. F. Stringer, M. L. Karow, and M. E. Rothenberg
The Eotaxin Chemokines and CCR3 Are Fundamental Regulators of Allergen-Induced Pulmonary Eosinophilia
J. Immunol., October 15, 2005; 175(8): 5341 - 5350.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Hartnell, A. Heinemann, D. M. Conroy, R. Wait, G. J. Sturm, M. Caversaccio, P. J. Jose, and T. J. Williams
Identification of Selective Basophil Chemoattractants in Human Nasal Polyps as Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2
J. Immunol., November 15, 2004; 173(10): 6448 - 6457.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Iikura, M. Ebisawa, M. Yamaguchi, H. Tachimoto, K. Ohta, K. Yamamoto, and K. Hirai
Transendothelial Migration of Human Basophils
J. Immunol., October 15, 2004; 173(8): 5189 - 5195.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. de Paulis, N. Prevete, I. Fiorentino, A. F. Walls, M. Curto, A. Petraroli, V. Castaldo, P. Ceppa, R. Fiocca, and G. Marone
Basophils Infiltrate Human Gastric Mucosa at Sites of Helicobacter pylori Infection, and Exhibit Chemotaxis in Response to H. pylori-derived Peptide Hp(2-20)
J. Immunol., June 15, 2004; 172(12): 7734 - 7743.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. Rojas-Ramos, A.F. Avalos, L. Perez-Fernandez, F. Cuevas-Schacht, E. Valencia-Maqueda, and L.M. Teran
Role of the chemokines RANTES, monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 in childhood asthma
Eur. Respir. J., August 1, 2003; 22(2): 310 - 316.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Phipps, S. Ying, A. Wangoo, Y.-E. Ong, F. Levi-Schaffer, and A. B. Kay
The Relationship Between Allergen-Induced Tissue Eosinophilia and Markers of Repair and Remodeling in Human Atopic Skin
J. Immunol., October 15, 2002; 169(8): 4604 - 4612.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
A.P. Badewa, C.E. Hudson, and A.S. Heiman
Regulatory Effects of Eotaxin, Eotaxin-2, and Eotaxin-3 on Eosinophil Degranulation and Superoxide Anion Generation
Experimental Biology and Medicine, September 1, 2002; 227(8): 645 - 651.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Menzies-Gow, S. Ying, I. Sabroe, V. L. Stubbs, D. Soler, T. J. Williams, and A. B. Kay
Eotaxin (CCL11) and Eotaxin-2 (CCL24) Induce Recruitment of Eosinophils, Basophils, Neutrophils, and Macrophages As Well As Features of Early- and Late-Phase Allergic Reactions Following Cutaneous Injection in Human Atopic and Nonatopic Volunteers
J. Immunol., September 1, 2002; 169(5): 2712 - 2718.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. E. L. Stubbs, P. Schratl, A. Hartnell, T. J. Williams, B. A. Peskar, A. Heinemann, and I. Sabroe
Indomethacin Causes Prostaglandin D2-like and Eotaxin-like Selective Responses in Eosinophils and Basophils
J. Biol. Chem., July 12, 2002; 277(29): 26012 - 26020.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Watanabe, P. J. Jose, and S. M. Rankin
Eotaxin-2 Generation Is Differentially Regulated by Lipopolysaccharide and IL-4 in Monocytes and Macrophages
J. Immunol., February 15, 2002; 168(4): 1911 - 1918.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Sabroe, C.M. Lloyd, M.K.B. Whyte, S.K. Dower, T.J. Williams, and J.E. Pease
Chemokines, innate and adaptive immunity, and respiratory disease
Eur. Respir. J., February 1, 2002; 19(2): 350 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. M. Lilly and B. L. Daugherty
A Novel LPS-Inducible CCR3 Activator . Why So Many CCR3 Ligands?
Am. J. Respir. Cell Mol. Biol., December 1, 2001; 25(6): 673 - 675.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
K. L. Denzler, M. T. Borchers, J. R. Crosby, G. Cieslewicz, E. M. Hines, J. P. Justice, S. A. Cormier, K. A. Lindenberger, W. Song, W. Wu, et al.
Extensive Eosinophil Degranulation and Peroxidase-Mediated Oxidation of Airway Proteins Do Not Occur in a Mouse Ovalbumin-Challenge Model of Pulmonary Inflammation
J. Immunol., August 1, 2001; 167(3): 1672 - 1682.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. Berkman, S. Ohnona, F. K. Chung, and R. Breuer
Eotaxin-3 but Not Eotaxin Gene Expression Is Upregulated in Asthmatics 24 Hours after Allergen Challenge
Am. J. Respir. Cell Mol. Biol., June 1, 2001; 24(6): 682 - 687.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A.B. Kay
Allergy and Allergic Diseases- First of Two Parts
N. Engl. J. Med., January 4, 2001; 344(1): 30 - 37.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Heinemann, A. Hartnell, V. E. L. Stubbs, K. Murakami, D. Soler, G. LaRosa, P. W. Askenase, T. J. Williams, and I. Sabroe
Basophil Responses to Chemokines Are Regulated by Both Sequential and Cooperative Receptor Signaling
J. Immunol., December 15, 2000; 165(12): 7224 - 7233.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Zimmermann, S. P. Hogan, A. Mishra, E. B. Brandt, T. R. Bodette, S. M. Pope, F. D. Finkelman, and M. E. Rothenberg
Murine Eotaxin-2: A Constitutive Eosinophil Chemokine Induced by Allergen Challenge and IL-4 Overexpression
J. Immunol., November 15, 2000; 165(10): 5839 - 5846.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. J. Haley, C. M. Lilly, J.-H. Yang, Y. Feng, S. P. Kennedy, T. G. Turi, J. F. Thompson, G. H. Sukhova, P. Libby, and R. T. Lee
Overexpression of Eotaxin and the CCR3 Receptor in Human Atherosclerosis : Using Genomic Technology to Identify a Potential Novel Pathway of Vascular Inflammation
Circulation, October 31, 2000; 102(18): 2185 - 2189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. N. KHAN, O. M. KON, A. J. MACFARLANE, Q. MENG, S. YING, N. C. BARNES, and A. BARRY KAY
Attenuation of the Allergen-induced Late Asthmatic Reaction by Cyclosporin A Is Associated with Inhibition of Bronchial Eosinophils, Interleukin-5, Granulocyte Macrophage Colony-Stimulating Factor, and Eotaxin
Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): 1377 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. LAMKHIOUED, E. A. GARCIA-ZEPEDA, S. ABI-YOUNES, H. NAKAMURA, S. JEDRZKIEWICZ, L. WAGNER, P. M. RENZI, Z. ALLAKHVERDI, C. LILLY, Q. HAMID, et al.
Monocyte Chemoattractant Protein (MCP)-4 Expression in the Airways of Patients with Asthma . Induction in Epithelial Cells and Mononuclear Cells by Proinflammatory Cytokines
Am. J. Respir. Crit. Care Med., August 1, 2000; 162(2): 723 - 732.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.