The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Faquim-Mauro, E. L.
Right arrow Articles by Macedo, M. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Faquim-Mauro, E. L.
Right arrow Articles by Macedo, M. S.
The Journal of Immunology, 1999, 163: 3572-3576.
Copyright © 1999 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Mouse IgG1 Antibodies Comprise Two Functionally Distinct Types That Are Differentially Regulated by IL-4 and IL-121

Eliana L. Faquim-Mauro*, Robert L. Coffman{dagger}, Ises A. Abrahamsohn* and Mahasti S. Macedo2,*

* Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; and {dagger} DNAX Research Institute, Palo Alto, CA 94304.

IL-4-dependent and -independent IgG1 Abs differ in their ability to induce mast cell degranulation as measured by passive cutaneous anaphylaxis (PCA). Mice immunized with OVA or PIII (fraction of Ascaris suum) produced high titers of IgG1 as shown by ELISA and PCA. In contrast, another A. suum fraction, PI, elicited IgG1 Abs with no PCA activity. IgG1 with anaphylactic activity required IL-4, as IgG1 responses to OVA and PIII in IL-4-/- mice gave no PCA. PI-specific IgG1 was IL-4-independent, because no difference was found between the responses of IL-4-/- and IL-4+/+ mice. Significant PCA reactions were elicited, however, with PI-specific IgG1 from IL-12-/- or anti-IFN-{gamma} Ab-treated mice, although less Ab was measured by ELISA. These results indicate that one type of IgG1 has anaphylactic activity and its synthesis is IL-4-dependent, being inhibited by IL-12 or IFN-{gamma}; the other lacks this activity and its synthesis is stimulated by IL-12 or IFN-{gamma}.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. R. Silva, A. Casabuono, J. F. Jacysyn, B. C. Favoretto, I. Fernandes, M. S. Macedo, A. S. Couto, and E. L. Faquim-Mauro
Sialic Acid Residues Are Essential for the Anaphylactic Activity of Murine IgG1 Antibodies
J. Immunol., December 15, 2008; 181(12): 8308 - 8314.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. B. Goncalves, O. Leshem, K. Bernards, J. R. Webb, P. P. Stashenko, and A. Campos-Neto
T-Cell Expression Cloning of Porphyromonas gingivalis Genes Coding for T Helper-Biased Immune Responses during Infection
Infect. Immun., July 1, 2006; 74(7): 3958 - 3966.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Lima, V. M. O. Souza, E. L. Faquim-Mauro, M. S. Hoshida, E. Bevilacqua, M. S. Macedo, W. Tavares-de-Lima, and B. B. Vargaftig
Modulation of the Induction of Lung and Airway Allergy in the Offspring of IFN-{gamma}-Treated Mother Mice
J. Immunol., September 15, 2005; 175(6): 3554 - 3559.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Matsumoto, M. Matsumoto, K. Umemori, Y. Ozeki, M. Furugen, T. Tatsuo, Y. Hirayama, S. Yamamoto, T. Yamada, and K. Kobayashi
DNA Augments Antigenicity of Mycobacterial DNA-Binding Protein 1 and Confers Protection against Mycobacterium tuberculosis Infection in Mice
J. Immunol., July 1, 2005; 175(1): 441 - 449.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Yasumi, K. Katamura, I. Okafuji, T. Yoshioka, T.-a. Meguro, R. Nishikomori, T. Kusunoki, T. Heike, and T. Nakahata
Limited Ability of Antigen-Specific Th1 Responses to Inhibit Th2 Cell Development In Vivo
J. Immunol., February 1, 2005; 174(3): 1325 - 1331.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. M. Smith, J. M. Brewer, C. M. Rush, J. Riley, and P. Garside
In Vivo Generated Th1 Cells Can Migrate to B Cell Follicles to Support B Cell Responses
J. Immunol., August 1, 2004; 173(3): 1640 - 1646.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Yasumi, K. Katamura, T. Yoshioka, T.-a. Meguro, R. Nishikomori, T. Heike, M. Inobe, S. Kon, T. Uede, and T. Nakahata
Differential Requirement for the CD40-CD154 Costimulatory Pathway during Th Cell Priming by CD8{alpha}+ and CD8{alpha}− Murine Dendritic Cell Subsets
J. Immunol., April 15, 2004; 172(8): 4826 - 4833.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. A. P. Oliveira, G. M. A. C. Lima, M. T. Shio, P. J. M. Leenen, and I. A. Abrahamsohn
Immature macrophages derived from mouse bone marrow produce large amounts of IL-12p40 after LPS stimulation
J. Leukoc. Biol., November 1, 2003; 74(5): 857 - 867.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Campos-Neto, J. R. Webb, K. Greeson, R. N. Coler, Y. A. W. Skeiky, and S. G. Reed
Vaccination with Plasmid DNA Encoding TSA/LmSTI1 Leishmanial Fusion Proteins Confers Protection against Leishmania major Infection in Susceptible BALB/c Mice
Infect. Immun., June 1, 2002; 70(6): 2828 - 2836.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Cote-Sierra, A. Bredan, C. M. Toldos, B. Stijlemans, L. Brys, P. Cornelis, M. Segovia, P. de Baetselier, and H. Revets
Bacterial Lipoprotein-Based Vaccines Induce Tumor Necrosis Factor-Dependent Type 1 Protective Immunity against Leishmania major
Infect. Immun., January 1, 2002; 70(1): 240 - 248.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Esfandiari, I. B. McInnes, G. Lindop, F.-P. Huang, M. Field, M. Komai-Koma, X.-q. Wei, and F. Y. Liew
A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease
J. Immunol., November 1, 2001; 167(9): 5338 - 5347.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. P. Mountford, K. G. Hogg, P. S. Coulson, and F. Brombacher
Signaling via Interleukin-4 Receptor {alpha} Chain Is Required for Successful Vaccination against Schistosomiasis in BALB/c Mice
Infect. Immun., January 1, 2001; 69(1): 228 - 236.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
E. L. Faquim-Mauro and M. S. Macedo
Induction of IL-4-dependent, anaphylactic-type and IL-4-Independent, non-anaphylactic-type IgG1 antibodies is modulated by adjuvants
Int. Immunol., December 1, 2000; 12(12): 1733 - 1740.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. L. Munson, B. K. Du Chateau, D. A. Jobe, S. D. Lovrich, S. M. Callister, and R. F. Schell
Production of Borreliacidal Antibody to Outer Surface Protein A In Vitro and Modulation by Interleukin-4
Infect. Immun., October 1, 2000; 68(10): 5496 - 5501.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Weiss, W. W. Leitner, S. Scheiblhofer, D. Chen, A. Bernhaupt, S. Mostbock, J. Thalhamer, and J. A. Lyon
Genetic Vaccination against Malaria Infection by Intradermal and Epidermal Injections of a Plasmid Containing the Gene Encoding the Plasmodium berghei Circumsporozoite Protein
Infect. Immun., October 1, 2000; 68(10): 5914 - 5919.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. M. Smith, L. Pottage, E. R. Thomas, A. J. Leishman, T. N. Doig, D. Xu, F. Y. Liew, and P. Garside
Th1 and Th2 CD4+ T Cells Provide Help for B Cell Clonal Expansion and Antibody Synthesis in a Similar Manner In Vivo
J. Immunol., September 15, 2000; 165(6): 3136 - 3144.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
G. De Becker, V. Moulin, B. Pajak, C. Bruck, M. Francotte, C. Thiriart, J. Urbain, and M. Moser
The adjuvant monophosphoryl lipid A increases the function of antigen-presenting cells
Int. Immunol., June 1, 2000; 12(6): 807 - 815.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.