| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Immunology, The Forsyth Institute, Boston, MA;
Division of Immunology, Children’s Hospital, Boston, MA;
Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA; and
§
Department of Microbiology, Hiroshima University Faculty of Dentistry, Hiroshima, Japan
Differentiated CD4 T cells can be divided into Th1 and Th2 types
based on the cytokines they produce. Differential expression of
chemokine receptors on either the Th1-type or the Th2-type cell
suggests that Th1-type and Th2-type cells differ not only in cytokine
production but also in their migratory capacity. Stimulation of
endothelial cells with IFN-
selectively enhanced transmigration of
Th1-type cells, but not Th2-type cells, in a transendothelial migration
assay. Enhanced transmigration of Th1-type cells was dependent on the
chemokine RANTES produced by endothelial cells, as indicated by the
findings that Ab neutralizing RANTES, or Ab to its receptor CCR5,
inhibited transmigration. Neutralizing Ab to chemokines
macrophage-inflammatory protein-1
or monocyte chemotactic protein-1
did not inhibit Th1 selective migration. Whereas anti-CD18 and
anti-CD54 blocked basal levels of Th1-type cell adherence to
endothelial cells and also inhibited transmigration, anti-RANTES
blocked only transmigration, indicating that RANTES appeared to induce
transmigration of adherent T cells. RANTES seemed to promote diapedesis
of adherent Th1-type cells by augmenting pseudopod formation in
conjunction with actin rearrangement by a pathway that was sensitive to
the phosphoinositol 3-kinase inhibitor wortmannin and to the Rho
GTP-binding protein inhibitor, epidermal cell differentiation
inhibitor. Thus, enhancement of Th1-type selective migration appeared
to be responsible for the diapedesis induced by interaction between
CCR5 on Th1-type cells and RANTES produced by endothelial cells.
Further evidence that CCR5 and RANTES play a modulatory role in
Th1-type selective migration derives from the abrogation of this
migration by anti-RANTES and anti-CCR5
Abs.
This article has been cited by other articles:
|
|
 |
|
  T. T. Murooka, R. Rahbar, L. C. Platanias, and E. N. Fish CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1 Blood, May 15, 2008; 111(10): 4892 - 4901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Schroder, R. N. Pierson III, B.-N. H. Nguyen, D. W. Kawka, L. B. Peterson, G. Wu, T. Zhang, M. S. Springer, S. J. Siciliano, S. Iliff, et al. CCR5 Blockade Modulates Inflammation and Alloimmunity in Primates J. Immunol., August 15, 2007; 179(4): 2289 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Turner, E. Olivas, A. Gutierrez, G. Diaz, and P. C. Doherty Disregulated Influenza A Virus-Specific CD8+ T Cell Homeostasis in the Absence of IFN-{gamma} Signaling J. Immunol., June 15, 2007; 178(12): 7616 - 7622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Ajuebor, Z. Wondimu, C. M. Hogaboam, T. Le, A. E.I. Proudfoot, and M. G. Swain CCR5 Deficiency Drives Enhanced Natural Killer Cell Trafficking to and Activation within the Liver in Murine T Cell-Mediated Hepatitis Am. J. Pathol., June 1, 2007; 170(6): 1975 - 1988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Cavusoglu, C. Eng, V. Chopra, L. T. Clark, D. J. Pinsky, and J. D. Marmur Low Plasma RANTES Levels Are an Independent Predictor of Cardiac Mortality in Patients Referred for Coronary Angiography Arterioscler. Thromb. Vasc. Biol., April 1, 2007; 27(4): 929 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Schreiber, V. Shinder, D. W. Cain, R. Alon, and R. Sackstein Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm Blood, February 15, 2007; 109(4): 1381 - 1386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kawai, T. Matsuyama, Y. Hosokawa, S. Makihira, M. Seki, N. Y. Karimbux, R. B. Goncalves, P. Valverde, S. Dibart, Y.-P. Li, et al. B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease Am. J. Pathol., September 1, 2006; 169(3): 987 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. T. Murooka, M. M. Wong, R. Rahbar, B. Majchrzak-Kita, A. E. I. Proudfoot, and E. N. Fish CCL5-CCR5-mediated Apoptosis in T Cells: REQUIREMENT FOR GLYCOSAMINOGLYCAN BINDING AND CCL5 AGGREGATION J. Biol. Chem., September 1, 2006; 281(35): 25184 - 25194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zernecke, E. A. Liehn, J.-L. Gao, W. A. Kuziel, P. M. Murphy, and C. Weber Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10 Blood, June 1, 2006; 107(11): 4240 - 4243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Baba, A. Ishizu, S. Iwasaki, A. Suzuki, U. Tomaru, H. Ikeda, T. Yoshiki, and M. Kasahara CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype Blood, March 1, 2006; 107(5): 2004 - 2012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Matsuyama, T. Kawai, Y. Izumi, and M. A Taubman Expression of Major Histocompatibility Complex Class II and CD80 by Gingival Epithelial Cells Induces Activation of CD4+ T Cells in Response to Bacterial Challenge Infect. Immun., February 1, 2005; 73(2): 1044 - 1051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Skwor, H. Cho, C. Cassidy, T. Yoshimura, and D. N. McMurray Recombinant guinea pig CCL5 (RANTES) differentially modulates cytokine production in alveolar and peritoneal macrophages J. Leukoc. Biol., December 1, 2004; 76(6): 1229 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sarween, A. Chodos, C. Raykundalia, M. Khan, A. K. Abbas, and L. S. K. Walker CD4+CD25+ Cells Controlling a Pathogenic CD4 Response Inhibit Cytokine Differentiation, CXCR-3 Expression, and Tissue Invasion J. Immunol., September 1, 2004; 173(5): 2942 - 2951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Gergel and M. B. Furie Populations of Human T Lymphocytes That Traverse the Vascular Endothelium Stimulated by Borrelia burgdorferi Are Enriched with Cells That Secrete Gamma Interferon Infect. Immun., March 1, 2004; 72(3): 1530 - 1536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Stanford and T. B. Issekutz The relative activity of CXCR3 and CCR5 ligands in T lymphocyte migration: concordant and disparate activities in vitro and in vivo J. Leukoc. Biol., November 1, 2003; 74(5): 791 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Mallat, A. Gojova, V. Sauzeau, V. Brun, J.-S. Silvestre, B. Esposito, R. Merval, H. Groux, G. Loirand, and A. Tedgui Rho-Associated Protein Kinase Contributes to Early Atherosclerotic Lesion Formation in Mice Circ. Res., October 31, 2003; 93(9): 884 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gao, X.-Y. Zhou, Y. Yashiro-Ohtani, Y.-F. Yang, N. Sugimoto, S. Ono, T. Nakanishi, S. Obika, T. Imanishi, T. Egawa, et al. The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3 J. Leukoc. Biol., February 1, 2003; 73(2): 273 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Poggi, M. R. Zocchi, R. Carosio, E. Ferrero, D. F. Angelini, S. Galgani, M. D. Caramia, G. Bernardi, G. Borsellino, and L. Battistini Transendothelial Migratory Pathways of V{delta}1+TCR{gamma}{delta}+ and V{delta}2+TCR{gamma}{delta}+ T Lymphocytes from Healthy Donors and Multiple Sclerosis Patients: Involvement of Phosphatidylinositol 3 Kinase and Calcium Calmodulin-Dependent Kinase II J. Immunol., June 15, 2002; 168(12): 6071 - 6077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Savinov, F. S. Wong, and A. V. Chervonsky IFN-{gamma} Affects Homing of Diabetogenic T Cells J. Immunol., December 1, 2001; 167(11): 6637 - 6643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Sundstrom, L. K. McMullan, C. F. Spiropoulou, W. C. Hooper, A. A. Ansari, C. J. Peters, and P. E. Rollin Hantavirus Infection Induces the Expression of RANTES and IP-10 without Causing Increased Permeability in Human Lung Microvascular Endothelial Cells J. Virol., July 1, 2001; 75(13): 6070 - 6085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.-H. Cho, S.-Y. Seong, M.-S. Choi, and I.-S. Kim Expression of Chemokine Genes in Human Dermal Microvascular Endothelial Cell Lines Infected with Orientia tsutsugamushi Infect. Immun., March 1, 2001; 69(3): 1265 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Ding, K. Xiong, and T. B. Issekutz Chemokines stimulate human T lymphocyte transendothelial migration to utilize VLA-4 in addition to LFA-1 J. Leukoc. Biol., March 1, 2001; 69(3): 458 - 466. [Abstract] [Full Text]
|
|
|
|
 |
|
 M.A. Taubman and T. Kawai Involvement of T-Lymphocytes in Periodontal Disease and in Direct and Indirect Induction of Bone Resorption Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(2): 125 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zhang, N. W. Lukacs, V. A. Lawless, S. L. Kunkel, and M. H. Kaplan Cutting Edge: Differential Expression of Chemokines in Th1 and Th2 Cells Is Dependent on Stat6 But Not Stat4 J. Immunol., July 1, 2000; 165(1): 10 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kawai, M. Seki, H. Watanabe, J. W. Eastcott, D. J. Smith, and M. A. Taubman Th1 transmigration anergy: a new concept of endothelial cell-T cell regulatory interaction Int. Immunol., June 1, 2000; 12(6): 937 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kawai, R. Eisen-Lev, M. Seki, J. W. Eastcott, M. E. Wilson, and M. A. Taubman Requirement of B7 Costimulation for Th1-Mediated Inflammatory Bone Resorption in Experimental Periodontal Disease J. Immunol., February 15, 2000; 164(4): 2102 - 2109. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
