HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maldonado, M. A. Articles by Eisenberg, R. A. Search for Related Content PubMed PubMed Citation Articles by Maldonado, M. A. Articles by Eisenberg, R. A.

Differential Control of Autoantibodies and Lymphoproliferation by Fas Ligand Expression on CD4⁺ and CD8⁺ T Cells In Vivo^{1 ,2}

Michael A. Maldonado^3,*, Glen C. MacDonald^3,, Vellalore N. Kakkanaiah, Karamarie Fecho, Mark Dransfield, Debora Sekiguchi^*, Philip L. Cohen^* and Robert A. Eisenberg^4,*

^* Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and Departments of Medicine and Microbiology/Immunology, University of North Carolina, Chapel Hill, NC 27599

We have previously shown that the gld autoimmune syndrome is suppressed in lethally irradiated gld mice reconstituted with a mixture of normal and gld bone marrow (BM). Furthermore, in vivo depletion of normal Thy-1⁺ cells restores lymphoproliferation and autoantibody production in such chimeras, suggesting that T cells bearing Fas ligand are responsible for correcting the gld defect. In this study, mixed-BM chimeras lacking either normal CD4⁺ (B6CD4KO-B6gld) or normal CD8⁺ T cells (B6CD8KO-B6gld) were generated to determine the contribution of the normal T cell subsets to disease suppression. Lymphoproliferation was completely suppressed in B6CD4KO-B6gld chimeras but only modestly in B6CD8KO-B6gld chimeras. On the other hand, both types of mixed-BM chimeras had incomplete effects on the suppression of serum autoantibodies when compared with B6gld reconstituted with isologous BM. These results suggest that both T cell subsets provide Fas ligand to suppress immune cells responsible for autoantibody production; however, CD8⁺ T cells are mainly responsible for preventing lymphoproliferation.

This article has been cited by other articles:

				I. Puliaeva, R. Puliaev, A. Shustov, M. Haas, and C. S. Via Fas Expression on Antigen-Specific T Cells Has Costimulatory, Helper, and Down-Regulatory Functions In Vivo for Cytotoxic T Cell Responses but Not for T Cell-Dependent B Cell Responses J. Immunol., November 1, 2008; 181(9): 5912 - 5929. [Abstract] [Full Text] [PDF]

				G. De Panfilis, A. Caruso, P. Sansoni, G. Pasolini, D. Semenza, and C. Torresani Identification of Fas-L-Expressing Apoptotic T Lymphocytes in Normal Human Peripheral Blood : In Vivo Suicide Am. J. Pathol., February 1, 2001; 158(2): 387 - 391. [Abstract] [Full Text] [PDF]