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14+ T Cells and Responsiveness to a Superantigen, Yersinia pseudotuberculosis- Derived Mitogen1
Departments of
*
Microbiology and Immunology and
Oral and Maxillofacial Surgery, and
Institute of Laboratory Animals, Tokyo Women’s Medical University, Tokyo, Japan; and
§
Laboratory of Immunology, Department of Medical Science, A. Avogadro University of Eastern Piedmont, Novara, Italy
We examined the expression of the H4 T cell activation marker in
thymic T cell subpopulations and found that TCR-
ß+
CD4+ thymic T cells are segregated into three
subpopulations based upon H4 levels. Thymic T cells with either no or
low H4 expression differentiate via the mainstream differentiation
pathway in the thymus. H4int thymic T cells, which express
a skewed Vß repertoire of Vß2, -7, and -8 in their TCRs, show the
phenotype of NKT cells: CD44high, Ly6Chigh,
NK1.1+, and TCR-ßlow. H4high
thymic T cells also show a skewed Vß repertoire, Vß2, -7, and -8,
and predominantly express an invariant V14-J281+
-chain in their TCRs but constitute a distinct population in that
they are CD44int, Ly6C-, NK1.1-,
and TCR-ßhigh. Thus, invariant V14+
thymic T cells consist of ordinary NKT cells and a new type of T cell
population. Vß7+ and Vß8.1+ invariant
V14+ thymic T cells are present in DBA/2 mice, which
carry mammary tumor virus-7-encoded superantigens, in comparable levels
to those in BALB/c mice. Furthermore, Vß7+ invariant
V14+ thymic T cells in DBA/2 mice are in the
immunologically responsive state, and Yersinia
pseudotuberculosis-derived mitogen-induced Vß7+
invariant V14+ thymic T cell blasts from DBA/2 and
BALB/c mice exhibited equally enhanced responses upon restimulation
with Y. pseudotuberculosis-derived mitogen. Thus, invariant
V14+ thymic T cells that escape negative selection in
DBA/2 mice contain T cells as functionally mature as those in BALB/c
mice.
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