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T Cells That Express a Very Restricted TCR Repertoire Are Preferentially Localized in Liver and Spleen1
*
Howard Hughes Medical Institute, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; and
Unité du Développement des Lymphocytes, Centre National de la Recherche Scientifique, URA 1961, and
Unité de Biologie Moléculaire du Gène, Institut National de la Santé et de la Recherche Medicale, Unité 277, Institut Pasteur, Paris, France
IL-4-producing 
thymocytes in normal mice belong to a
distinct subset of T cells characterized by low expression of
Thy-1. This thymocyte subset shares a number of phenotypic and
functional properties with the NK T cell population.
Thy-1dull thymocytes in DBA/2 mice express a
restricted repertoire of TCRs that are composed of the V1 gene
product mainly associated with the V6.4 chain and exhibit limited
junctional sequence diversity. Using mice transgenic for a rearranged
V1J4C4 chain and a novel mAb (9D3) specific for the V6.3
and V6.4 murine TCR chains, we have analyzed the peripheral
localization and functional properties of T cells displaying a
similarly restricted TCR repertoire. In transgenic mice, IL-4
production by peripheral T cells was confined to the
+9D3+ subset, which contains cells with a
TCR repertoire similar to that found in Thy-1dull
thymocytes. In normal DBA/2 mice such cells represent close to half of
the T cells present in the liver and around 20% of the splenic
T cells.
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