HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Damoiseaux, J. G. M. C. Articles by Saoudi, A. Search for Related Content PubMed PubMed Citation Articles by Damoiseaux, J. G. M. C. Articles by Saoudi, A.

A Dominant Role for the Thymus and MHC Genes in Determining the Peripheral CD4/CD8 T Cell Ratio in the Rat¹

Jan G. M. C. Damoiseaux^2,*, Bastien Cautain, Isabelle Bernard, Magali Mas, Peter J. C. van Breda Vriesman^*, Philippe Druet, Gilbert Fournié and Abdelhadi Saoudi

^* Department of Internal Medicine, Section Immunology, University Maastricht, Maastricht, The Netherlands, and Institut National de la Santé et de la Recherche Médicale U28, Hôpital Purpan, Place du Dr Baylac, Toulouse, France

During their development, immature CD4CD8 double positive thymocytes become committed to either the CD4 or CD8 lineage. The final size of the peripheral CD4 and CD8 T cell compartments depends on thymic output and on the differential survival and proliferation of the respective T cell subsets in the periphery. Our results reveal that the development of the distinct peripheral CD4/CD8 T cell ratio between Lewis and Brown Norway rats originates in the thymus and, as shown by the use of radiation bone marrow chimeras, is determined by selection on radio-resistant stromal cells. Furthermore, this difference is strictly correlated with the MHC haplotype and is the result of a reduction in the absolute number of CD8 T cells in Brown Norway rats. These data suggest that the distinct CD4/CD8 T cell ratio between these two rat strains is the consequence of differential interactions of the TCR/CD8 coreceptor complex with the respective MHC class I haplotypes during selection in the thymus.

This article has been cited by other articles:

				C. Carter, C. Dion, S. Schnell, W. J. Coadwell, M. Graham, L. Hepburn, G. Morgan, A. Hutchings, J. C. Pascall, H. Jacobs, et al. A Natural Hypomorphic Variant of the Apoptosis Regulator Gimap4/IAN1 J. Immunol., August 1, 2007; 179(3): 1784 - 1795. [Abstract] [Full Text] [PDF]

				J. Karlsson, X. Zhao, I. Lonskaya, M. Neptin, R. Holmdahl, and A. Andersson Novel Quantitative Trait Loci Controlling Development of Experimental Autoimmune Encephalomyelitis and Proportion of Lymphocyte Subpopulations J. Immunol., January 15, 2003; 170(2): 1019 - 1026. [Abstract] [Full Text] [PDF]

				E. S. Sobel, L. Morel, R. Baert, C. Mohan, J. Schiffenbauer, and E. K. Wakeland Genetic Dissection of Systemic Lupus Erythematosus Pathogenesis: Evidence for Functional Expression of Sle3/5 by Non-T Cells J. Immunol., October 1, 2002; 169(7): 4025 - 4032. [Abstract] [Full Text] [PDF]

				B. Cautain, J. Damoiseaux, I. Bernard, E. Xystrakis, E. Fournie, P. van Breda Vriesman, P. Druet, and A. Saoudi The CD8 T Cell Compartment Plays a Dominant Role in the Deficiency of Brown-Norway Rats to Mount a Proper Type 1 Immune Response J. Immunol., January 1, 2002; 168(1): 162 - 170. [Abstract] [Full Text] [PDF]

				E. Jimenez, A. Vicente, R. Sacedon, J. J. Munoz, G. Weinmaster, A. G. Zapata, and A. Varas Distinct Mechanisms Contribute to Generate and Change the CD4:CD8 Cell Ratio During Thymus Development: A Role for the Notch Ligand, Jagged1 J. Immunol., May 15, 2001; 166(10): 5898 - 5908. [Abstract] [Full Text] [PDF]