| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Comparative Medicine, University of Alabama, Birmingham, AL 35294;
Cell Biology and Inflammation Research, Pharmacia & Upjohn, Kalamazoo, MI 49001;
Department of Molecular and Human Genetics, Baylor College of Medicine and Howard Hughes Medical Institute, Houston, TX 77030
P-selectin plays an important role in leukocyte adherence to microvascular endothelium and is expressed in synovial tissue from patients with rheumatoid arthritis (RA). However, the contribution of P-selectin to the initiation and chronicity of joint inflammation is not well understood. In these studies, collagen-induced arthritis (CIA) was induced in P-selectin mutant (-/-) mice to explore the role of P-selectin in the development of joint inflammation. Surprisingly, CIA onset was accelerated and severity was increased in P-selectin mutant mice, compared with wild-type mice (+/+). Increased levels of anti-type II collagen IgG were detected in both nonarthritic and arthritic P-selectin mutant mice from days 14–91. In addition, splenocytes isolated from immunized and nonimmunized P-selectin mutant mice produced significantly less IL-2 and IL-4, but significantly higher levels of IL-10 and IL-5 than splenocytes from wild-type mice. These observations show that P-selectin-mediated leukocyte rolling is not required for the development of murine CIA and that P-selectin expression exerts a controlling effect on the development of Ag-driven inflammatory joint disease, possibly by mediating the recruitment and/or trafficking of specific leukocyte subtypes into lymphoid tissue or inflammatory foci.
This article has been cited by other articles:
|
|
 |
|
  A. Urzainqui, G. Martinez del Hoyo, A. Lamana, H. de la Fuente, O. Barreiro, I. M. Olazabal, P. Martin, M. K. Wild, D. Vestweber, R. Gonzalez-Amaro, et al. Functional Role of P-Selectin Glycoprotein Ligand 1/P-Selectin Interaction in the Generation of Tolerogenic Dendritic Cells J. Immunol., December 1, 2007; 179(11): 7457 - 7465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yanaba, Y. Hamaguchi, G. M. Venturi, D. A. Steeber, E. W. St. Clair, and T. F. Tedder B Cell Depletion Delays Collagen-Induced Arthritis in Mice: Arthritis Induction Requires Synergy between Humoral and Cell-Mediated Immunity J. Immunol., July 15, 2007; 179(2): 1369 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Fujita, M. Fujimoto, T. Matsushita, Y. Shimada, M. Hasegawa, Y. Kuwano, F. Ogawa, K. Takehara, and S. Sato Phase-Dependent Roles of E-Selectin during Chronic Contact Hypersensitivity Responses Am. J. Pathol., May 1, 2007; 170(5): 1649 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. He, T. R. Schoeb, A. Panoskaltsis-Mortari, K. R. Zinn, R. A. Kesterson, J. Zhang, S. Samuel, M. J. Hicks, M. J. Hickey, and D. C. Bullard Deficiency of P-Selectin or P-Selectin Glycoprotein Ligand-1 Leads to Accelerated Development of Glomerulonephritis and Increased Expression of CC Chemokine Ligand 2 in Lupus-Prone Mice J. Immunol., December 15, 2006; 177(12): 8748 - 8756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Horikawa, M. Fujimoto, M. Hasegawa, T. Matsushita, Y. Hamaguchi, A. Kawasuji, Y. Matsushita, T. Fujita, F. Ogawa, K. Takehara, et al. E- and P-Selectins Synergistically Inhibit Bleomycin-Induced Pulmonary Fibrosis Am. J. Pathol., September 1, 2006; 169(3): 740 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-H. Shao, A. Del Prete, C. B. Bock, and B. Haribabu Targeted Disruption of Leukotriene B4 Receptors BLT1 and BLT2: A Critical Role for BLT1 in Collagen-Induced Arthritis in Mice J. Immunol., May 15, 2006; 176(10): 6254 - 6261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Y. Larbi, J. P. Dangerfield, F. J. Culley, D. Marshall, D. O. Haskard, P. J. Jose, T. J. Williams, and S. Nourshargh P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses J. Leukoc. Biol., January 1, 2003; 73(1): 65 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Carvalho-Tavares, M. J. Hickey, J. Hutchison, J. Michaud, I. T. Sutcliffe, and P. Kubes A Role for Platelets and Endothelial Selectins in Tumor Necrosis Factor-{alpha}-Induced Leukocyte Recruitment in the Brain Microvasculature Circ. Res., December 8, 2000; 87(12): 1141 - 1148. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
