| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Istituto di Microbiologia, Università di Messina, Facoltà di Medicina e Chirurgia, Messina, Italy
This study was undertaken to test the hypothesis that altered IL-10 production plays a role in the increased susceptibility of neonates to listeriosis. Plasma IL-10 levels were measured in neonatal and adult mice at various times after infection with Listeria monocytogenes. Relative to adults, neonatal mice had markedly increased IL-10 levels early in the course of infection with Listeria using a 90% lethal dose. Higher neonatal IL-10 responses were also observed after injecting adults and pups with equal doses of killed organisms. Splenic macrophages from neonates produced higher IL-10 levels than those of adults after in vitro stimulation with killed bacteria, confirming in vivo observations. Moreover, IL-10 blockade had differential effects in neonates and adults infected with live Listeria. In adult mice, anti-IL-10 Abs decreased bacterial burden early in the course of infection, but were no longer effective at 6 days or later after challenge. In the pups, however, the same treatment had beneficial effects both early and late during infection and resulted in increased survival. Collectively, our data suggest that an overproduction of IL-10 by macrophages may at least partially explain the increased susceptibility of neonates to listeriosis, and provide further evidence that cytokine production is different in adults and neonates.
This article has been cited by other articles:
|
|
 |
|
  M.-I. Fernandez, B. Regnault, C. Mulet, M. Tanguy, P. Jay, P. J. Sansonetti, and T. Pedron Maturation of Paneth Cells Induces the Refractory State of Newborn Mice to Shigella Infection J. Immunol., April 1, 2008; 180(7): 4924 - 4930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, E. Deriaud, X. Jiao, D. Braun, C. Leclerc, and R. Lo-Man Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells J. Exp. Med., May 14, 2007; 204(5): 1107 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Echeverry, K. Schesser, and B. Adkins Murine Neonates Are Highly Resistant to Yersinia enterocolitica following Orogastric Exposure Infect. Immun., May 1, 2007; 75(5): 2234 - 2243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Kollmann, B. Reikie, D. Blimkie, S. S. Way, A. M. Hajjar, K. Arispe, A. Shaulov, and C. B. Wilson Induction of Protective Immunity to Listeria monocytogenes in Neonates J. Immunol., March 15, 2007; 178(6): 3695 - 3701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Mancuso, A. Midiri, C. Biondo, C. Beninati, S. Zummo, R. Galbo, F. Tomasello, M. Gambuzza, G. Macri, A. Ruggeri, et al. Type I IFN Signaling Is Crucial for Host Resistance against Different Species of Pathogenic Bacteria J. Immunol., March 1, 2007; 178(5): 3126 - 3133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Foulds, M. J. Rotte, and R. A. Seder IL-10 Is Required for Optimal CD8 T Cell Memory following Listeria monocytogenes Infection J. Immunol., August 15, 2006; 177(4): 2565 - 2574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Jeyarajah, M. L. Kielar, H. Saboorian, P. Karimi, N. Frantz, and C. Y. Lu Impact of bile duct obstruction on hepatic E. coli infection: role of IL-10. Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G91 - G94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pasche, S. Kalaydjiev, T. J. Franz, E. Kremmer, V. Gailus-Durner, H. Fuchs, M. Hrabe de Angelis, A. Lengeling, and D. H. Busch Sex-Dependent Susceptibility to Listeria monocytogenes Infection Is Mediated by Differential Interleukin-10 Production Infect. Immun., September 1, 2005; 73(9): 5952 - 5960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Chelvarajan, S. M. Collins, I. E. Doubinskaia, S. Goes, J. Van Willigen, D. Flanagan, W. J. S. de Villiers, J. S. Bryson, and S. Bondada Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigens J. Leukoc. Biol., June 1, 2004; 75(6): 982 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Biondo, C. Beninati, M. Bombaci, L. Messina, G. Mancuso, A. Midiri, R. Galbo, and G. Teti Induction of T Helper Type 1 Responses by a Polysaccharide Deacetylase from Cryptococcus neoformans Infect. Immun., September 1, 2003; 71(9): 5412 - 5417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Silva, T. F. Pais, and R. Appelberg Blocking the Receptor for IL-10 Improves Antimycobacterial Chemotherapy and Vaccination J. Immunol., August 1, 2001; 167(3): 1535 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Silva and R. Appelberg Blocking the Receptor for Interleukin 10 Protects Mice from Lethal Listeriosis Antimicrob. Agents Chemother., April 1, 2001; 45(4): 1312 - 1314. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
