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Max-Planck-Institut für Biologie, Abt. Immungenetik, Tübingen, Germany
Sequencing of zebrafish (Danio rerio) bacterial
artificial chromosome and P1 artificial chromosome genomic clone
fragments and of cDNA clones has led to the identification of five new
loci coding for ß subunits of proteasomes (PSMB).
Together with the four genes identified previously, nine
PSMB genes have now been defined in the zebrafish. Six
of the nine genes reside in the zebrafish MHC (Mhc)
class I region, four of them reside in a single cluster closely
associated with TAP2 on a 26-kb long genomic fragment,
and two reside at some distance from the fragment. In addition to
homologues of the human genes PSMB5 through
PSMB9, two new genes, PSMB11 and
PSMB12, have been found for which there are no known
corresponding genes in humans. The new genes reside in the
PSMB cluster in the Mhc. Homology and
promoter region analysis suggest that the Mhc-associated
genes might be inducible by IFN-
. The zebrafish class I region
contains representatives of three phylogenetically distinguishable
groups of PSMB genes, X, Y, and
Z. It is proposed that these genes were present in the
ancestral PSMB region before Mhc class I
genes became associated with it.
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