The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Eijk, M.
Right arrow Articles by de Groot, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Eijk, M.
Right arrow Articles by de Groot, C.
The Journal of Immunology, 1999, 163: 2478-2482.
Copyright © 1999 by The American Association of Immunologists

Germinal Center B Cell Apoptosis Requires Both Caspase and Cathepsin Activity

Marco van Eijk and Cornelis de Groot1

Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Follicular dendritic cells (FDCs) select B cells during germinal center (GC) reactions. The B cells that are able to bind to the FDCs receive a signal that leads to the termination of endonuclease activity in the nuclei of those B cells. This signal must be in addition to the signals transferred through the cross-linkage of the B cell receptors and signals resulting from the interactions of the adhesion molecules lymphocyte function-associated Ag-1 and very late Ag-4 with ICAM-1 and VCAM-1, respectively. In this report, we present evidence that the FDCs silence all apoptotic processes in GC B lymphocytes and additionally switch off pre-present endonuclease activity. We also show that GC B cell apoptosis requires cathepsin activity downstream of caspase-3. This cathepsin activity is directly connected to endonuclease activity and therefore may be an interesting target for the antiapoptotic factors produced by FDCs.




This article has been cited by other articles:


Home page
 haematolHome page
J.-J. Goval, C. Thielen, C. Bourguignon, R. Greimers, E. Dejardin, Y. S. Choi, J. Boniver, and L. de Leval
The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP
Haematologica, August 1, 2008; 93(8): 1169 - 1177.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. A. G. M. Cillessen, J. C. Reed, K. Welsh, C. Pinilla, R. Houghten, E. Hooijberg, J. Deurhof, K. C. M. Castricum, P. Kortman, C. J. Hess, et al.
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells
Blood, January 1, 2008; 111(1): 369 - 375.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. A.G.M. Cillessen, C. J. Hess, E. Hooijberg, K. C.M. Castricum, P. Kortman, F. Denkers, W. Vos, M. A. van de Wiel, G. J. Schuurhuis, G. J. Ossenkoppele, et al.
Inhibition of the Intrinsic Apoptosis Pathway Downstream of Caspase-9 Activation Causes Chemotherapy Resistance in Diffuse Large B-Cell Lymphoma
Clin. Cancer Res., December 1, 2007; 13(23): 7012 - 7021.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
K. van Nierop, F. J.M. Muller, J. Stap, C. J.F. Van Noorden, M. van Eijk, and C. de Groot
Lysosomal Destabilization Contributes to Apoptosis of Germinal Center B-lymphocytes
J. Histochem. Cytochem., December 1, 2006; 54(12): 1425 - 1435.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Huber, C. Thielen, H. Seeger, P. Schwarz, F. Montrasio, M. R. Wilson, E. Heinen, Y.-X. Fu, G. Miele, and A. Aguzzi
Lymphotoxin-{beta} Receptor-Dependent Genes in Lymph Node and Follicular Dendritic Cell Transcriptomes
J. Immunol., May 1, 2005; 174(9): 5526 - 5536.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. E. Meyer-Hermann and P. K. Maini
Cutting Edge: Back to "One-Way" Germinal Centers
J. Immunol., March 1, 2005; 174(5): 2489 - 2493.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. M. Jackson and J. D. Capra
IgH V-Region Sequence Does Not Predict the Survival Fate of Human Germinal Center B Cells
J. Immunol., March 1, 2005; 174(5): 2805 - 2813.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-S. Park, S.-O. Yoon, R. J. Armitage, and Y. S. Choi
Follicular Dendritic Cells Produce IL-15 That Enhances Germinal Center B Cell Proliferation in Membrane-Bound Form
J. Immunol., December 1, 2004; 173(11): 6676 - 6683.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M.-C. Michallet, F. Saltel, M. Flacher, J.-P. Revillard, and L. Genestier
Cathepsin-Dependent Apoptosis Triggered by Supraoptimal Activation of T Lymphocytes: A Possible Mechanism of High Dose Tolerance
J. Immunol., May 1, 2004; 172(9): 5405 - 5414.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M.-C. Michallet, F. Saltel, X. Preville, M. Flacher, J.-P. Revillard, and L. Genestier
Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion
Blood, November 15, 2003; 102(10): 3719 - 3726.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E.-L. Marchand, S. Der Sarkissian, P. Hamet, and D. deBlois
Caspase-Dependent Cell Death Mediates the Early Phase of Aortic Hypertrophy Regression in Losartan-Treated Spontaneously Hypertensive Rats
Circ. Res., April 18, 2003; 92(7): 777 - 784.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Thorburn, L. M. Bender, M. J. Morgan, and A. Thorburn
Caspase- and Serine Protease-dependent Apoptosis by the Death Domain of FADD in Normal Epithelial Cells
Mol. Biol. Cell, January 1, 2003; 14(1): 67 - 77.
[Abstract] [Full Text]

Home page
 Int ImmunolHome page
T. Beyer, M. Meyer-Hermann, and G. Soff
A possible role of chemotaxis in germinal center formation
Int. Immunol., December 1, 2002; 14(12): 1369 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. Matarrese, L. Di Biase, L. Santodonato, E. Straface, M. Mecchia, B. Ascione, G. Parmiani, F. Belardelli, M. Ferrantini, and W. Malorni
Type I Interferon Gene Transfer Sensitizes Melanoma Cells to Apoptosis via a Target Activity on Mitochondrial Function
Am. J. Pathol., April 1, 2002; 160(4): 1507 - 1520.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. van Eijk, J. P. Medema, and C. de Groot
Cutting Edge: Cellular Fas-Associated Death Domain-Like IL-1-Converting Enzyme-Inhibitory Protein Protects Germinal Center B Cells from Apoptosis During Germinal Center Reactions
J. Immunol., June 1, 2001; 166(11): 6473 - 6476.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. Hennino, M. Berard, P. H. Krammer, and T. Defrance
Flice-Inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis
J. Exp. Med., February 19, 2001; 193(4): 447 - 458.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Katz, M. R. Deehan, S. Seatter, C. Lord, R. D. Sturrock, and M. M. Harnett
B Cell Receptor-Stimulated Mitochondrial Phospholipase A2 Activation and Resultant Disruption of Mitochondrial Membrane Potential Correlate with the Induction of Apoptosis in WEHI-231 B Cells
J. Immunol., January 1, 2001; 166(1): 137 - 147.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.